7KRG

Crystal Structure of Mannitol Dehydrogenase (ChMDH) from Cladosporium herbarum in complex with NADP+ and Na

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
A	0019594	biological_process	mannitol metabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0050085	molecular_function	mannitol 2-dehydrogenase (NADP+) activity
A	0050661	molecular_function	NADP binding
A	0050664	molecular_function	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
A	0051289	biological_process	protein homotetramerization
B	0016491	molecular_function	oxidoreductase activity
B	0019594	biological_process	mannitol metabolic process
B	0042803	molecular_function	protein homodimerization activity
B	0050085	molecular_function	mannitol 2-dehydrogenase (NADP+) activity
B	0050661	molecular_function	NADP binding
B	0050664	molecular_function	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
B	0051289	biological_process	protein homotetramerization
C	0016491	molecular_function	oxidoreductase activity
C	0019594	biological_process	mannitol metabolic process
C	0042803	molecular_function	protein homodimerization activity
C	0050085	molecular_function	mannitol 2-dehydrogenase (NADP+) activity
C	0050661	molecular_function	NADP binding
C	0050664	molecular_function	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
C	0051289	biological_process	protein homotetramerization
D	0016491	molecular_function	oxidoreductase activity
D	0019594	biological_process	mannitol metabolic process
D	0042803	molecular_function	protein homodimerization activity
D	0050085	molecular_function	mannitol 2-dehydrogenase (NADP+) activity
D	0050661	molecular_function	NADP binding
D	0050664	molecular_function	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
D	0051289	biological_process	protein homotetramerization
E	0016491	molecular_function	oxidoreductase activity
E	0019594	biological_process	mannitol metabolic process
E	0042803	molecular_function	protein homodimerization activity
E	0050085	molecular_function	mannitol 2-dehydrogenase (NADP+) activity
E	0050661	molecular_function	NADP binding
E	0050664	molecular_function	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
E	0051289	biological_process	protein homotetramerization
F	0016491	molecular_function	oxidoreductase activity
F	0019594	biological_process	mannitol metabolic process
F	0042803	molecular_function	protein homodimerization activity
F	0050085	molecular_function	mannitol 2-dehydrogenase (NADP+) activity
F	0050661	molecular_function	NADP binding
F	0050664	molecular_function	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
F	0051289	biological_process	protein homotetramerization
G	0016491	molecular_function	oxidoreductase activity
G	0019594	biological_process	mannitol metabolic process
G	0042803	molecular_function	protein homodimerization activity
G	0050085	molecular_function	mannitol 2-dehydrogenase (NADP+) activity
G	0050661	molecular_function	NADP binding
G	0050664	molecular_function	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
G	0051289	biological_process	protein homotetramerization
H	0016491	molecular_function	oxidoreductase activity
H	0019594	biological_process	mannitol metabolic process
H	0042803	molecular_function	protein homodimerization activity
H	0050085	molecular_function	mannitol 2-dehydrogenase (NADP+) activity
H	0050661	molecular_function	NADP binding
H	0050664	molecular_function	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
H	0051289	biological_process	protein homotetramerization

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"20420880","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"20420880","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Active site: {"description":"Lowers pKa of active site Tyr","evidences":[{"source":"PubMed","id":"20420880","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O93868","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"L0E2Z4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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