7KQ0

PCNA bound to peptide mimetic

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
A	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0001673	cellular_component	male germ cell nucleus
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003684	molecular_function	damaged DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005652	cellular_component	nuclear lamina
A	0005654	cellular_component	nucleoplasm
A	0005657	cellular_component	replication fork
A	0005813	cellular_component	centrosome
A	0006260	biological_process	DNA replication
A	0006272	biological_process	leading strand elongation
A	0006275	biological_process	regulation of DNA replication
A	0006281	biological_process	DNA repair
A	0006287	biological_process	base-excision repair, gap-filling
A	0006298	biological_process	mismatch repair
A	0006325	biological_process	chromatin organization
A	0006974	biological_process	DNA damage response
A	0006979	biological_process	response to oxidative stress
A	0007507	biological_process	heart development
A	0016604	cellular_component	nuclear body
A	0019899	molecular_function	enzyme binding
A	0019985	biological_process	translesion synthesis
A	0030331	molecular_function	nuclear estrogen receptor binding
A	0030337	molecular_function	DNA polymerase processivity factor activity
A	0030855	biological_process	epithelial cell differentiation
A	0030894	cellular_component	replisome
A	0030971	molecular_function	receptor tyrosine kinase binding
A	0031297	biological_process	replication fork processing
A	0032077	biological_process	positive regulation of deoxyribonuclease activity
A	0032139	molecular_function	dinucleotide insertion or deletion binding
A	0032355	biological_process	response to estradiol
A	0032405	molecular_function	MutLalpha complex binding
A	0033993	biological_process	response to lipid
A	0034644	biological_process	cellular response to UV
A	0035035	molecular_function	histone acetyltransferase binding
A	0042802	molecular_function	identical protein binding
A	0043596	cellular_component	nuclear replication fork
A	0043626	cellular_component	PCNA complex
A	0044849	biological_process	estrous cycle
A	0044877	molecular_function	protein-containing complex binding
A	0045739	biological_process	positive regulation of DNA repair
A	0045740	biological_process	positive regulation of DNA replication
A	0046686	biological_process	response to cadmium ion
A	0070062	cellular_component	extracellular exosome
A	0070182	molecular_function	DNA polymerase binding
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0070557	cellular_component	PCNA-p21 complex
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0071548	biological_process	response to dexamethasone
A	0097421	biological_process	liver regeneration
A	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
A	1902065	biological_process	response to L-glutamate
A	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
C	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0001673	cellular_component	male germ cell nucleus
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0003684	molecular_function	damaged DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005652	cellular_component	nuclear lamina
C	0005654	cellular_component	nucleoplasm
C	0005657	cellular_component	replication fork
C	0005813	cellular_component	centrosome
C	0006260	biological_process	DNA replication
C	0006272	biological_process	leading strand elongation
C	0006275	biological_process	regulation of DNA replication
C	0006281	biological_process	DNA repair
C	0006287	biological_process	base-excision repair, gap-filling
C	0006298	biological_process	mismatch repair
C	0006325	biological_process	chromatin organization
C	0006974	biological_process	DNA damage response
C	0006979	biological_process	response to oxidative stress
C	0007507	biological_process	heart development
C	0016604	cellular_component	nuclear body
C	0019899	molecular_function	enzyme binding
C	0019985	biological_process	translesion synthesis
C	0030331	molecular_function	nuclear estrogen receptor binding
C	0030337	molecular_function	DNA polymerase processivity factor activity
C	0030855	biological_process	epithelial cell differentiation
C	0030894	cellular_component	replisome
C	0030971	molecular_function	receptor tyrosine kinase binding
C	0031297	biological_process	replication fork processing
C	0032077	biological_process	positive regulation of deoxyribonuclease activity
C	0032139	molecular_function	dinucleotide insertion or deletion binding
C	0032355	biological_process	response to estradiol
C	0032405	molecular_function	MutLalpha complex binding
C	0033993	biological_process	response to lipid
C	0034644	biological_process	cellular response to UV
C	0035035	molecular_function	histone acetyltransferase binding
C	0042802	molecular_function	identical protein binding
C	0043596	cellular_component	nuclear replication fork
C	0043626	cellular_component	PCNA complex
C	0044849	biological_process	estrous cycle
C	0044877	molecular_function	protein-containing complex binding
C	0045739	biological_process	positive regulation of DNA repair
C	0045740	biological_process	positive regulation of DNA replication
C	0046686	biological_process	response to cadmium ion
C	0070062	cellular_component	extracellular exosome
C	0070182	molecular_function	DNA polymerase binding
C	0070301	biological_process	cellular response to hydrogen peroxide
C	0070557	cellular_component	PCNA-p21 complex
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	0071548	biological_process	response to dexamethasone
C	0097421	biological_process	liver regeneration
C	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
C	1902065	biological_process	response to L-glutamate
C	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
E	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
E	0000781	cellular_component	chromosome, telomeric region
E	0000785	cellular_component	chromatin
E	0001673	cellular_component	male germ cell nucleus
E	0003677	molecular_function	DNA binding
E	0003682	molecular_function	chromatin binding
E	0003684	molecular_function	damaged DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005652	cellular_component	nuclear lamina
E	0005654	cellular_component	nucleoplasm
E	0005657	cellular_component	replication fork
E	0005813	cellular_component	centrosome
E	0006260	biological_process	DNA replication
E	0006272	biological_process	leading strand elongation
E	0006275	biological_process	regulation of DNA replication
E	0006281	biological_process	DNA repair
E	0006287	biological_process	base-excision repair, gap-filling
E	0006298	biological_process	mismatch repair
E	0006325	biological_process	chromatin organization
E	0006974	biological_process	DNA damage response
E	0006979	biological_process	response to oxidative stress
E	0007507	biological_process	heart development
E	0016604	cellular_component	nuclear body
E	0019899	molecular_function	enzyme binding
E	0019985	biological_process	translesion synthesis
E	0030331	molecular_function	nuclear estrogen receptor binding
E	0030337	molecular_function	DNA polymerase processivity factor activity
E	0030855	biological_process	epithelial cell differentiation
E	0030894	cellular_component	replisome
E	0030971	molecular_function	receptor tyrosine kinase binding
E	0031297	biological_process	replication fork processing
E	0032077	biological_process	positive regulation of deoxyribonuclease activity
E	0032139	molecular_function	dinucleotide insertion or deletion binding
E	0032355	biological_process	response to estradiol
E	0032405	molecular_function	MutLalpha complex binding
E	0033993	biological_process	response to lipid
E	0034644	biological_process	cellular response to UV
E	0035035	molecular_function	histone acetyltransferase binding
E	0042802	molecular_function	identical protein binding
E	0043596	cellular_component	nuclear replication fork
E	0043626	cellular_component	PCNA complex
E	0044849	biological_process	estrous cycle
E	0044877	molecular_function	protein-containing complex binding
E	0045739	biological_process	positive regulation of DNA repair
E	0045740	biological_process	positive regulation of DNA replication
E	0046686	biological_process	response to cadmium ion
E	0070062	cellular_component	extracellular exosome
E	0070182	molecular_function	DNA polymerase binding
E	0070301	biological_process	cellular response to hydrogen peroxide
E	0070557	cellular_component	PCNA-p21 complex
E	0071466	biological_process	cellular response to xenobiotic stimulus
E	0071548	biological_process	response to dexamethasone
E	0097421	biological_process	liver regeneration
E	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
E	1902065	biological_process	response to L-glutamate
E	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication

Functional Information from PROSITE/UniProt

site_id	PS00293
Number of Residues	19
Details	PCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlaMgvnLtSMsKIL

Chain	Residue	Details
A	ARG61-LEU79

---

site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GVnLqSMDsSHVsLVqLtLrsegF

Chain	Residue	Details
A	GLY34-PHE57

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	57
Details	DNA binding: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	279
Details	Region: {"description":"Interaction with NUDT15","evidences":[{"source":"PubMed","id":"19419956","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19419956","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine; by EGFR","evidences":[{"source":"PubMed","id":"17115032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38459011","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"17108083","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17130289","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine; by PKA, PKB/AKT1, PIM1 and PIM2","evidences":[{"source":"PubMed","id":"10753973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11463845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12431783","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16982699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20307683","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by PKC and NUAK1","evidences":[{"source":"PubMed","id":"10753973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25329316","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---