7KO0
Crystal structure of the second bromodomain (BD2) of human BRD4 bound to SG3-179
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue 5W2 A 501 |
| Chain | Residue |
| A | LYS355 |
| A | VAL439 |
| A | HOH639 |
| A | TRP374 |
| A | PRO375 |
| A | PHE376 |
| A | VAL380 |
| A | LEU385 |
| A | ASN433 |
| A | HIS437 |
| A | GLU438 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | ILE393 |
| A | ILE394 |
| A | LYS395 |
| A | HIS396 |
| A | ASN428 |
| A | LYS431 |
| A | ASP459 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Site: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
