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7KKU

X-ray Counterpart to Neutron Structure of Oxidized Human MnSOD

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0000303biological_processresponse to superoxide
A0001666biological_processresponse to hypoxia
A0001836biological_processrelease of cytochrome c from mitochondria
A0001889biological_processliver development
A0003032biological_processdetection of oxygen
A0003069biological_processacetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
A0003677molecular_functionDNA binding
A0004784molecular_functionsuperoxide dismutase activity
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006357biological_processregulation of transcription by RNA polymerase II
A0006749biological_processglutathione metabolic process
A0006801biological_processsuperoxide metabolic process
A0006979biological_processresponse to oxidative stress
A0007005biological_processmitochondrion organization
A0007507biological_processheart development
A0007626biological_processlocomotory behavior
A0008217biological_processregulation of blood pressure
A0008285biological_processnegative regulation of cell population proliferation
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0008631biological_processintrinsic apoptotic signaling pathway in response to oxidative stress
A0008637biological_processapoptotic mitochondrial changes
A0009410biological_processresponse to xenobiotic stimulus
A0009791biological_processpost-embryonic development
A0010042biological_processresponse to manganese ion
A0010043biological_processresponse to zinc ion
A0010269biological_processresponse to selenium ion
A0010332biological_processresponse to gamma radiation
A0010729biological_processpositive regulation of hydrogen peroxide biosynthetic process
A0014823biological_processresponse to activity
A0016491molecular_functionoxidoreductase activity
A0019430biological_processremoval of superoxide radicals
A0019825molecular_functionoxygen binding
A0019899molecular_functionenzyme binding
A0022904biological_processrespiratory electron transport chain
A0030097biological_processhemopoiesis
A0030145molecular_functionmanganese ion binding
A0030335biological_processpositive regulation of cell migration
A0031667biological_processresponse to nutrient levels
A0032364biological_processintracellular oxygen homeostasis
A0032496biological_processresponse to lipopolysaccharide
A0033591biological_processresponse to L-ascorbic acid
A0034021biological_processresponse to silicon dioxide
A0034599biological_processcellular response to oxidative stress
A0035900biological_processresponse to isolation stress
A0035902biological_processresponse to immobilization stress
A0042311biological_processvasodilation
A0042542biological_processresponse to hydrogen peroxide
A0042554biological_processsuperoxide anion generation
A0042645cellular_componentmitochondrial nucleoid
A0042743biological_processhydrogen peroxide metabolic process
A0042802molecular_functionidentical protein binding
A0043066biological_processnegative regulation of apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045599biological_processnegative regulation of fat cell differentiation
A0046686biological_processresponse to cadmium ion
A0046872molecular_functionmetal ion binding
A0048147biological_processnegative regulation of fibroblast proliferation
A0048666biological_processneuron development
A0048678biological_processresponse to axon injury
A0048773biological_processerythrophore differentiation
A0050665biological_processhydrogen peroxide biosynthetic process
A0051289biological_processprotein homotetramerization
A0051602biological_processresponse to electrical stimulus
A0051881biological_processregulation of mitochondrial membrane potential
A0055093biological_processresponse to hyperoxia
A0060586biological_processmulticellular organismal-level iron ion homeostasis
A0070062cellular_componentextracellular exosome
A0071000biological_processresponse to magnetism
A0071361biological_processcellular response to ethanol
A0072593biological_processreactive oxygen species metabolic process
A1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1902631biological_processnegative regulation of membrane hyperpolarization
A1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
A1905461biological_processpositive regulation of vascular associated smooth muscle cell apoptotic process
A1905932biological_processpositive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
B0000302biological_processresponse to reactive oxygen species
B0000303biological_processresponse to superoxide
B0001666biological_processresponse to hypoxia
B0001836biological_processrelease of cytochrome c from mitochondria
B0001889biological_processliver development
B0003032biological_processdetection of oxygen
B0003069biological_processacetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
B0003677molecular_functionDNA binding
B0004784molecular_functionsuperoxide dismutase activity
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006357biological_processregulation of transcription by RNA polymerase II
B0006749biological_processglutathione metabolic process
B0006801biological_processsuperoxide metabolic process
B0006979biological_processresponse to oxidative stress
B0007005biological_processmitochondrion organization
B0007507biological_processheart development
B0007626biological_processlocomotory behavior
B0008217biological_processregulation of blood pressure
B0008285biological_processnegative regulation of cell population proliferation
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0008631biological_processintrinsic apoptotic signaling pathway in response to oxidative stress
B0008637biological_processapoptotic mitochondrial changes
B0009410biological_processresponse to xenobiotic stimulus
B0009791biological_processpost-embryonic development
B0010042biological_processresponse to manganese ion
B0010043biological_processresponse to zinc ion
B0010269biological_processresponse to selenium ion
B0010332biological_processresponse to gamma radiation
B0010729biological_processpositive regulation of hydrogen peroxide biosynthetic process
B0014823biological_processresponse to activity
B0016491molecular_functionoxidoreductase activity
B0019430biological_processremoval of superoxide radicals
B0019825molecular_functionoxygen binding
B0019899molecular_functionenzyme binding
B0022904biological_processrespiratory electron transport chain
B0030097biological_processhemopoiesis
B0030145molecular_functionmanganese ion binding
B0030335biological_processpositive regulation of cell migration
B0031667biological_processresponse to nutrient levels
B0032364biological_processintracellular oxygen homeostasis
B0032496biological_processresponse to lipopolysaccharide
B0033591biological_processresponse to L-ascorbic acid
B0034021biological_processresponse to silicon dioxide
B0034599biological_processcellular response to oxidative stress
B0035900biological_processresponse to isolation stress
B0035902biological_processresponse to immobilization stress
B0042311biological_processvasodilation
B0042542biological_processresponse to hydrogen peroxide
B0042554biological_processsuperoxide anion generation
B0042645cellular_componentmitochondrial nucleoid
B0042743biological_processhydrogen peroxide metabolic process
B0042802molecular_functionidentical protein binding
B0043066biological_processnegative regulation of apoptotic process
B0043524biological_processnegative regulation of neuron apoptotic process
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0045599biological_processnegative regulation of fat cell differentiation
B0046686biological_processresponse to cadmium ion
B0046872molecular_functionmetal ion binding
B0048147biological_processnegative regulation of fibroblast proliferation
B0048666biological_processneuron development
B0048678biological_processresponse to axon injury
B0048773biological_processerythrophore differentiation
B0050665biological_processhydrogen peroxide biosynthetic process
B0051289biological_processprotein homotetramerization
B0051602biological_processresponse to electrical stimulus
B0051881biological_processregulation of mitochondrial membrane potential
B0055093biological_processresponse to hyperoxia
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071000biological_processresponse to magnetism
B0071361biological_processcellular response to ethanol
B0072593biological_processreactive oxygen species metabolic process
B1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B1902631biological_processnegative regulation of membrane hyperpolarization
B1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
B1905461biological_processpositive regulation of vascular associated smooth muscle cell apoptotic process
B1905932biological_processpositive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
Functional Information from PROSITE/UniProt
site_idPS00088
Number of Residues8
DetailsSOD_MN Manganese and iron superoxide dismutases signature. DvWEHAYY
ChainResidueDetails
AASP159-TYR166

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:10852710, ECO:0000269|PubMed:11580280, ECO:0000269|PubMed:1394426, ECO:0000269|PubMed:19265433, ECO:0000269|PubMed:9537987, ECO:0000269|PubMed:9537988, ECO:0000312|PDB:1JA8, ECO:0007744|PDB:1AP5, ECO:0007744|PDB:1AP6, ECO:0007744|PDB:1EM1, ECO:0007744|PDB:1N0J, ECO:0007744|PDB:1QNM, ECO:0007744|PDB:1ZSP, ECO:0007744|PDB:1ZTE, ECO:0007744|PDB:1ZUQ, ECO:0007744|PDB:2P4K
ChainResidueDetails
BASP159
BHIS163
AHIS163
BHIS26
BHIS74
AHIS26
AHIS74
AASP159

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: 3'-nitrotyrosine => ECO:0000269|PubMed:10334867, ECO:0000269|PubMed:16399855
ChainResidueDetails
BTYR34
ATYR34

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P09671
ChainResidueDetails
ALYS98
ALYS106
BLYS44
BLYS51
BLYS98
BLYS106
ALYS51
ALYS44

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P09671
ChainResidueDetails
ALYS90
ALYS178
BLYS90
BLYS178

219869

PDB entries from 2024-05-15

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