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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7KKU

X-ray Counterpart to Neutron Structure of Oxidized Human MnSOD

Functional Information from GO Data
ChainGOidnamespacecontents
A0000303biological_processresponse to superoxide
A0001666biological_processresponse to hypoxia
A0001836biological_processrelease of cytochrome c from mitochondria
A0003069biological_processacetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
A0003677molecular_functionDNA binding
A0004784molecular_functionsuperoxide dismutase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006357biological_processregulation of transcription by RNA polymerase II
A0006801biological_processsuperoxide metabolic process
A0006979biological_processresponse to oxidative stress
A0008217biological_processregulation of blood pressure
A0008285biological_processnegative regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0010042biological_processresponse to manganese ion
A0010043biological_processresponse to zinc ion
A0010269biological_processresponse to selenium ion
A0010729biological_processpositive regulation of hydrogen peroxide biosynthetic process
A0014823biological_processresponse to activity
A0016491molecular_functionoxidoreductase activity
A0019430biological_processremoval of superoxide radicals
A0019825molecular_functionoxygen binding
A0019899molecular_functionenzyme binding
A0030145molecular_functionmanganese ion binding
A0030335biological_processpositive regulation of cell migration
A0031667biological_processresponse to nutrient levels
A0032364biological_processintracellular oxygen homeostasis
A0032496biological_processresponse to lipopolysaccharide
A0033591biological_processresponse to L-ascorbic acid
A0034021biological_processresponse to silicon dioxide
A0034599biological_processcellular response to oxidative stress
A0035900biological_processresponse to isolation stress
A0035902biological_processresponse to immobilization stress
A0042542biological_processresponse to hydrogen peroxide
A0042645cellular_componentmitochondrial nucleoid
A0042743biological_processhydrogen peroxide metabolic process
A0042802molecular_functionidentical protein binding
A0043066biological_processnegative regulation of apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0046686biological_processresponse to cadmium ion
A0046872molecular_functionmetal ion binding
A0050665biological_processhydrogen peroxide biosynthetic process
A0051289biological_processprotein homotetramerization
A0051602biological_processresponse to electrical stimulus
A0070062cellular_componentextracellular exosome
A0071000biological_processresponse to magnetism
A0071361biological_processcellular response to ethanol
A1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1902631biological_processnegative regulation of membrane hyperpolarization
A1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
A1905461biological_processpositive regulation of vascular associated smooth muscle cell apoptotic process
A1905932biological_processpositive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
B0000303biological_processresponse to superoxide
B0001666biological_processresponse to hypoxia
B0001836biological_processrelease of cytochrome c from mitochondria
B0003069biological_processacetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure
B0003677molecular_functionDNA binding
B0004784molecular_functionsuperoxide dismutase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006357biological_processregulation of transcription by RNA polymerase II
B0006801biological_processsuperoxide metabolic process
B0006979biological_processresponse to oxidative stress
B0008217biological_processregulation of blood pressure
B0008285biological_processnegative regulation of cell population proliferation
B0009410biological_processresponse to xenobiotic stimulus
B0010042biological_processresponse to manganese ion
B0010043biological_processresponse to zinc ion
B0010269biological_processresponse to selenium ion
B0010729biological_processpositive regulation of hydrogen peroxide biosynthetic process
B0014823biological_processresponse to activity
B0016491molecular_functionoxidoreductase activity
B0019430biological_processremoval of superoxide radicals
B0019825molecular_functionoxygen binding
B0019899molecular_functionenzyme binding
B0030145molecular_functionmanganese ion binding
B0030335biological_processpositive regulation of cell migration
B0031667biological_processresponse to nutrient levels
B0032364biological_processintracellular oxygen homeostasis
B0032496biological_processresponse to lipopolysaccharide
B0033591biological_processresponse to L-ascorbic acid
B0034021biological_processresponse to silicon dioxide
B0034599biological_processcellular response to oxidative stress
B0035900biological_processresponse to isolation stress
B0035902biological_processresponse to immobilization stress
B0042542biological_processresponse to hydrogen peroxide
B0042645cellular_componentmitochondrial nucleoid
B0042743biological_processhydrogen peroxide metabolic process
B0042802molecular_functionidentical protein binding
B0043066biological_processnegative regulation of apoptotic process
B0043524biological_processnegative regulation of neuron apoptotic process
B0046686biological_processresponse to cadmium ion
B0046872molecular_functionmetal ion binding
B0050665biological_processhydrogen peroxide biosynthetic process
B0051289biological_processprotein homotetramerization
B0051602biological_processresponse to electrical stimulus
B0070062cellular_componentextracellular exosome
B0071000biological_processresponse to magnetism
B0071361biological_processcellular response to ethanol
B1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B1902631biological_processnegative regulation of membrane hyperpolarization
B1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
B1905461biological_processpositive regulation of vascular associated smooth muscle cell apoptotic process
B1905932biological_processpositive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
Functional Information from PROSITE/UniProt
site_idPS00088
Number of Residues8
DetailsSOD_MN Manganese and iron superoxide dismutases signature. DvWEHAYY
ChainResidueDetails
AASP159-TYR166
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10852710","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11580280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1394426","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19265433","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9537987","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9537988","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JA8","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1AP5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1AP6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EM1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N0J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZSP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZTE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2P4K","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"PubMed","id":"10334867","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16399855","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P09671","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P09671","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

245663

PDB entries from 2025-12-03

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