7KK5
Structure of the catalytic domain of PARP1 in complex with niraparib
Functional Information from GO Data
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: For poly [ADP-ribose] polymerase activity => ECO:0000305|PubMed:32028527, ECO:0000305|PubMed:7852410, ECO:0000305|PubMed:9315851 |
| Chain | Residue | Details |
| A | GLU988 | |
| B | GLU988 | |
| C | GLU988 | |
| D | GLU988 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9UGN5 |
| Chain | Residue | Details |
| B | HIS862 | |
| B | GLY871 | |
| B | ARG878 | |
| B | SER904 | |
| C | HIS862 | |
| C | GLY871 | |
| C | ARG878 | |
| C | SER904 | |
| D | HIS862 | |
| D | GLY871 | |
| D | ARG878 | |
| D | SER904 | |
| A | GLY871 | |
| A | ARG878 | |
| A | SER904 | |
| A | HIS862 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER782 | |
| C | SER782 | |
| D | SER782 | |
| A | SER782 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER786 | |
| D | SER786 | |
| A | SER786 | |
| B | SER786 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| C | LYS748 | |
| D | LYS748 | |
| B | LYS748 | |
| A | LYS748 |
