7KJ1

human peroxiredoxin 2 - C172S mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002357	biological_process	defense response to tumor cell
A	0002536	biological_process	respiratory burst involved in inflammatory response
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0010310	biological_process	regulation of hydrogen peroxide metabolic process
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0019430	biological_process	removal of superoxide radicals
A	0030194	biological_process	positive regulation of blood coagulation
A	0031665	biological_process	negative regulation of lipopolysaccharide-mediated signaling pathway
A	0032496	biological_process	response to lipopolysaccharide
A	0034599	biological_process	cellular response to oxidative stress
A	0042098	biological_process	T cell proliferation
A	0042743	biological_process	hydrogen peroxide metabolic process
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042981	biological_process	regulation of apoptotic process
A	0043029	biological_process	T cell homeostasis
A	0043066	biological_process	negative regulation of apoptotic process
A	0043410	biological_process	positive regulation of MAPK cascade
A	0045321	biological_process	leukocyte activation
A	0045454	biological_process	cell redox homeostasis
A	0045581	biological_process	negative regulation of T cell differentiation
A	0048538	biological_process	thymus development
A	0051920	molecular_function	peroxiredoxin activity
A	0070062	cellular_component	extracellular exosome
A	0097191	biological_process	extrinsic apoptotic signaling pathway
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
A	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
A	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
B	0002357	biological_process	defense response to tumor cell
B	0002536	biological_process	respiratory burst involved in inflammatory response
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0010310	biological_process	regulation of hydrogen peroxide metabolic process
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0019430	biological_process	removal of superoxide radicals
B	0030194	biological_process	positive regulation of blood coagulation
B	0031665	biological_process	negative regulation of lipopolysaccharide-mediated signaling pathway
B	0032496	biological_process	response to lipopolysaccharide
B	0034599	biological_process	cellular response to oxidative stress
B	0042098	biological_process	T cell proliferation
B	0042743	biological_process	hydrogen peroxide metabolic process
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0042981	biological_process	regulation of apoptotic process
B	0043029	biological_process	T cell homeostasis
B	0043066	biological_process	negative regulation of apoptotic process
B	0043410	biological_process	positive regulation of MAPK cascade
B	0045321	biological_process	leukocyte activation
B	0045454	biological_process	cell redox homeostasis
B	0045581	biological_process	negative regulation of T cell differentiation
B	0048538	biological_process	thymus development
B	0051920	molecular_function	peroxiredoxin activity
B	0070062	cellular_component	extracellular exosome
B	0097191	biological_process	extrinsic apoptotic signaling pathway
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
B	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
C	0002357	biological_process	defense response to tumor cell
C	0002536	biological_process	respiratory burst involved in inflammatory response
C	0004601	molecular_function	peroxidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0010310	biological_process	regulation of hydrogen peroxide metabolic process
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0019430	biological_process	removal of superoxide radicals
C	0030194	biological_process	positive regulation of blood coagulation
C	0031665	biological_process	negative regulation of lipopolysaccharide-mediated signaling pathway
C	0032496	biological_process	response to lipopolysaccharide
C	0034599	biological_process	cellular response to oxidative stress
C	0042098	biological_process	T cell proliferation
C	0042743	biological_process	hydrogen peroxide metabolic process
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0042981	biological_process	regulation of apoptotic process
C	0043029	biological_process	T cell homeostasis
C	0043066	biological_process	negative regulation of apoptotic process
C	0043410	biological_process	positive regulation of MAPK cascade
C	0045321	biological_process	leukocyte activation
C	0045454	biological_process	cell redox homeostasis
C	0045581	biological_process	negative regulation of T cell differentiation
C	0048538	biological_process	thymus development
C	0051920	molecular_function	peroxiredoxin activity
C	0070062	cellular_component	extracellular exosome
C	0097191	biological_process	extrinsic apoptotic signaling pathway
C	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
C	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
C	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
D	0002357	biological_process	defense response to tumor cell
D	0002536	biological_process	respiratory burst involved in inflammatory response
D	0004601	molecular_function	peroxidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0010310	biological_process	regulation of hydrogen peroxide metabolic process
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0019430	biological_process	removal of superoxide radicals
D	0030194	biological_process	positive regulation of blood coagulation
D	0031665	biological_process	negative regulation of lipopolysaccharide-mediated signaling pathway
D	0032496	biological_process	response to lipopolysaccharide
D	0034599	biological_process	cellular response to oxidative stress
D	0042098	biological_process	T cell proliferation
D	0042743	biological_process	hydrogen peroxide metabolic process
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0042981	biological_process	regulation of apoptotic process
D	0043029	biological_process	T cell homeostasis
D	0043066	biological_process	negative regulation of apoptotic process
D	0043410	biological_process	positive regulation of MAPK cascade
D	0045321	biological_process	leukocyte activation
D	0045454	biological_process	cell redox homeostasis
D	0045581	biological_process	negative regulation of T cell differentiation
D	0048538	biological_process	thymus development
D	0051920	molecular_function	peroxiredoxin activity
D	0070062	cellular_component	extracellular exosome
D	0097191	biological_process	extrinsic apoptotic signaling pathway
D	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
D	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
D	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
E	0002357	biological_process	defense response to tumor cell
E	0002536	biological_process	respiratory burst involved in inflammatory response
E	0004601	molecular_function	peroxidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006979	biological_process	response to oxidative stress
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0010310	biological_process	regulation of hydrogen peroxide metabolic process
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0019430	biological_process	removal of superoxide radicals
E	0030194	biological_process	positive regulation of blood coagulation
E	0031665	biological_process	negative regulation of lipopolysaccharide-mediated signaling pathway
E	0032496	biological_process	response to lipopolysaccharide
E	0034599	biological_process	cellular response to oxidative stress
E	0042098	biological_process	T cell proliferation
E	0042743	biological_process	hydrogen peroxide metabolic process
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0042981	biological_process	regulation of apoptotic process
E	0043029	biological_process	T cell homeostasis
E	0043066	biological_process	negative regulation of apoptotic process
E	0043410	biological_process	positive regulation of MAPK cascade
E	0045321	biological_process	leukocyte activation
E	0045454	biological_process	cell redox homeostasis
E	0045581	biological_process	negative regulation of T cell differentiation
E	0048538	biological_process	thymus development
E	0051920	molecular_function	peroxiredoxin activity
E	0070062	cellular_component	extracellular exosome
E	0097191	biological_process	extrinsic apoptotic signaling pathway
E	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
E	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
E	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
F	0002357	biological_process	defense response to tumor cell
F	0002536	biological_process	respiratory burst involved in inflammatory response
F	0004601	molecular_function	peroxidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006979	biological_process	response to oxidative stress
F	0008379	molecular_function	thioredoxin peroxidase activity
F	0010310	biological_process	regulation of hydrogen peroxide metabolic process
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0019430	biological_process	removal of superoxide radicals
F	0030194	biological_process	positive regulation of blood coagulation
F	0031665	biological_process	negative regulation of lipopolysaccharide-mediated signaling pathway
F	0032496	biological_process	response to lipopolysaccharide
F	0034599	biological_process	cellular response to oxidative stress
F	0042098	biological_process	T cell proliferation
F	0042743	biological_process	hydrogen peroxide metabolic process
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0042981	biological_process	regulation of apoptotic process
F	0043029	biological_process	T cell homeostasis
F	0043066	biological_process	negative regulation of apoptotic process
F	0043410	biological_process	positive regulation of MAPK cascade
F	0045321	biological_process	leukocyte activation
F	0045454	biological_process	cell redox homeostasis
F	0045581	biological_process	negative regulation of T cell differentiation
F	0048538	biological_process	thymus development
F	0051920	molecular_function	peroxiredoxin activity
F	0070062	cellular_component	extracellular exosome
F	0097191	biological_process	extrinsic apoptotic signaling pathway
F	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
F	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
F	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
G	0002357	biological_process	defense response to tumor cell
G	0002536	biological_process	respiratory burst involved in inflammatory response
G	0004601	molecular_function	peroxidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006979	biological_process	response to oxidative stress
G	0008379	molecular_function	thioredoxin peroxidase activity
G	0010310	biological_process	regulation of hydrogen peroxide metabolic process
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0019430	biological_process	removal of superoxide radicals
G	0030194	biological_process	positive regulation of blood coagulation
G	0031665	biological_process	negative regulation of lipopolysaccharide-mediated signaling pathway
G	0032496	biological_process	response to lipopolysaccharide
G	0034599	biological_process	cellular response to oxidative stress
G	0042098	biological_process	T cell proliferation
G	0042743	biological_process	hydrogen peroxide metabolic process
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0042981	biological_process	regulation of apoptotic process
G	0043029	biological_process	T cell homeostasis
G	0043066	biological_process	negative regulation of apoptotic process
G	0043410	biological_process	positive regulation of MAPK cascade
G	0045321	biological_process	leukocyte activation
G	0045454	biological_process	cell redox homeostasis
G	0045581	biological_process	negative regulation of T cell differentiation
G	0048538	biological_process	thymus development
G	0051920	molecular_function	peroxiredoxin activity
G	0070062	cellular_component	extracellular exosome
G	0097191	biological_process	extrinsic apoptotic signaling pathway
G	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
G	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
G	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
H	0002357	biological_process	defense response to tumor cell
H	0002536	biological_process	respiratory burst involved in inflammatory response
H	0004601	molecular_function	peroxidase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006979	biological_process	response to oxidative stress
H	0008379	molecular_function	thioredoxin peroxidase activity
H	0010310	biological_process	regulation of hydrogen peroxide metabolic process
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0019430	biological_process	removal of superoxide radicals
H	0030194	biological_process	positive regulation of blood coagulation
H	0031665	biological_process	negative regulation of lipopolysaccharide-mediated signaling pathway
H	0032496	biological_process	response to lipopolysaccharide
H	0034599	biological_process	cellular response to oxidative stress
H	0042098	biological_process	T cell proliferation
H	0042743	biological_process	hydrogen peroxide metabolic process
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0042981	biological_process	regulation of apoptotic process
H	0043029	biological_process	T cell homeostasis
H	0043066	biological_process	negative regulation of apoptotic process
H	0043410	biological_process	positive regulation of MAPK cascade
H	0045321	biological_process	leukocyte activation
H	0045454	biological_process	cell redox homeostasis
H	0045581	biological_process	negative regulation of T cell differentiation
H	0048538	biological_process	thymus development
H	0051920	molecular_function	peroxiredoxin activity
H	0070062	cellular_component	extracellular exosome
H	0097191	biological_process	extrinsic apoptotic signaling pathway
H	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
H	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
H	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
I	0002357	biological_process	defense response to tumor cell
I	0002536	biological_process	respiratory burst involved in inflammatory response
I	0004601	molecular_function	peroxidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006979	biological_process	response to oxidative stress
I	0008379	molecular_function	thioredoxin peroxidase activity
I	0010310	biological_process	regulation of hydrogen peroxide metabolic process
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0019430	biological_process	removal of superoxide radicals
I	0030194	biological_process	positive regulation of blood coagulation
I	0031665	biological_process	negative regulation of lipopolysaccharide-mediated signaling pathway
I	0032496	biological_process	response to lipopolysaccharide
I	0034599	biological_process	cellular response to oxidative stress
I	0042098	biological_process	T cell proliferation
I	0042743	biological_process	hydrogen peroxide metabolic process
I	0042744	biological_process	hydrogen peroxide catabolic process
I	0042981	biological_process	regulation of apoptotic process
I	0043029	biological_process	T cell homeostasis
I	0043066	biological_process	negative regulation of apoptotic process
I	0043410	biological_process	positive regulation of MAPK cascade
I	0045321	biological_process	leukocyte activation
I	0045454	biological_process	cell redox homeostasis
I	0045581	biological_process	negative regulation of T cell differentiation
I	0048538	biological_process	thymus development
I	0051920	molecular_function	peroxiredoxin activity
I	0070062	cellular_component	extracellular exosome
I	0097191	biological_process	extrinsic apoptotic signaling pathway
I	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
I	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
I	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
J	0002357	biological_process	defense response to tumor cell
J	0002536	biological_process	respiratory burst involved in inflammatory response
J	0004601	molecular_function	peroxidase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006979	biological_process	response to oxidative stress
J	0008379	molecular_function	thioredoxin peroxidase activity
J	0010310	biological_process	regulation of hydrogen peroxide metabolic process
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0019430	biological_process	removal of superoxide radicals
J	0030194	biological_process	positive regulation of blood coagulation
J	0031665	biological_process	negative regulation of lipopolysaccharide-mediated signaling pathway
J	0032496	biological_process	response to lipopolysaccharide
J	0034599	biological_process	cellular response to oxidative stress
J	0042098	biological_process	T cell proliferation
J	0042743	biological_process	hydrogen peroxide metabolic process
J	0042744	biological_process	hydrogen peroxide catabolic process
J	0042981	biological_process	regulation of apoptotic process
J	0043029	biological_process	T cell homeostasis
J	0043066	biological_process	negative regulation of apoptotic process
J	0043410	biological_process	positive regulation of MAPK cascade
J	0045321	biological_process	leukocyte activation
J	0045454	biological_process	cell redox homeostasis
J	0045581	biological_process	negative regulation of T cell differentiation
J	0048538	biological_process	thymus development
J	0051920	molecular_function	peroxiredoxin activity
J	0070062	cellular_component	extracellular exosome
J	0097191	biological_process	extrinsic apoptotic signaling pathway
J	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
J	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
J	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	ACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000305|PubMed:11904290

Chain	Residue	Details
A	CYS51
J	CYS51
B	CYS51
C	CYS51
D	CYS51
E	CYS51
F	CYS51
G	CYS51
H	CYS51
I	CYS51

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	ALA2
J	ALA2
B	ALA2
C	ALA2
D	ALA2
E	ALA2
F	ALA2
G	ALA2
H	ALA2
I	ALA2

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site_id	SWS_FT_FI3
Number of Residues	10
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER112
J	SER112
B	SER112
C	SER112
D	SER112
E	SER112
F	SER112
G	SER112
H	SER112
I	SER112

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site_id	SWS_FT_FI4
Number of Residues	10
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	THR182
J	THR182
B	THR182
C	THR182
D	THR182
E	THR182
F	THR182
G	THR182
H	THR182
I	THR182

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