7KIZ

reduced human peroxiredoxin 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002357	biological_process	defense response to tumor cell
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0019430	biological_process	removal of superoxide radicals
A	0030194	biological_process	positive regulation of blood coagulation
A	0034599	biological_process	cellular response to oxidative stress
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042981	biological_process	regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
A	0045321	biological_process	leukocyte activation
A	0045454	biological_process	cell redox homeostasis
A	0051920	molecular_function	peroxiredoxin activity
A	0070062	cellular_component	extracellular exosome
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	0002357	biological_process	defense response to tumor cell
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0019430	biological_process	removal of superoxide radicals
B	0030194	biological_process	positive regulation of blood coagulation
B	0034599	biological_process	cellular response to oxidative stress
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0042981	biological_process	regulation of apoptotic process
B	0043066	biological_process	negative regulation of apoptotic process
B	0045321	biological_process	leukocyte activation
B	0045454	biological_process	cell redox homeostasis
B	0051920	molecular_function	peroxiredoxin activity
B	0070062	cellular_component	extracellular exosome
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
C	0002357	biological_process	defense response to tumor cell
C	0004601	molecular_function	peroxidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0019430	biological_process	removal of superoxide radicals
C	0030194	biological_process	positive regulation of blood coagulation
C	0034599	biological_process	cellular response to oxidative stress
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0042981	biological_process	regulation of apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process
C	0045321	biological_process	leukocyte activation
C	0045454	biological_process	cell redox homeostasis
C	0051920	molecular_function	peroxiredoxin activity
C	0070062	cellular_component	extracellular exosome
C	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
D	0002357	biological_process	defense response to tumor cell
D	0004601	molecular_function	peroxidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0019430	biological_process	removal of superoxide radicals
D	0030194	biological_process	positive regulation of blood coagulation
D	0034599	biological_process	cellular response to oxidative stress
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0042981	biological_process	regulation of apoptotic process
D	0043066	biological_process	negative regulation of apoptotic process
D	0045321	biological_process	leukocyte activation
D	0045454	biological_process	cell redox homeostasis
D	0051920	molecular_function	peroxiredoxin activity
D	0070062	cellular_component	extracellular exosome
D	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
E	0002357	biological_process	defense response to tumor cell
E	0004601	molecular_function	peroxidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006979	biological_process	response to oxidative stress
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0019430	biological_process	removal of superoxide radicals
E	0030194	biological_process	positive regulation of blood coagulation
E	0034599	biological_process	cellular response to oxidative stress
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0042981	biological_process	regulation of apoptotic process
E	0043066	biological_process	negative regulation of apoptotic process
E	0045321	biological_process	leukocyte activation
E	0045454	biological_process	cell redox homeostasis
E	0051920	molecular_function	peroxiredoxin activity
E	0070062	cellular_component	extracellular exosome
E	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
F	0002357	biological_process	defense response to tumor cell
F	0004601	molecular_function	peroxidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006979	biological_process	response to oxidative stress
F	0008379	molecular_function	thioredoxin peroxidase activity
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0019430	biological_process	removal of superoxide radicals
F	0030194	biological_process	positive regulation of blood coagulation
F	0034599	biological_process	cellular response to oxidative stress
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0042981	biological_process	regulation of apoptotic process
F	0043066	biological_process	negative regulation of apoptotic process
F	0045321	biological_process	leukocyte activation
F	0045454	biological_process	cell redox homeostasis
F	0051920	molecular_function	peroxiredoxin activity
F	0070062	cellular_component	extracellular exosome
F	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
G	0002357	biological_process	defense response to tumor cell
G	0004601	molecular_function	peroxidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006979	biological_process	response to oxidative stress
G	0008379	molecular_function	thioredoxin peroxidase activity
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0019430	biological_process	removal of superoxide radicals
G	0030194	biological_process	positive regulation of blood coagulation
G	0034599	biological_process	cellular response to oxidative stress
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0042981	biological_process	regulation of apoptotic process
G	0043066	biological_process	negative regulation of apoptotic process
G	0045321	biological_process	leukocyte activation
G	0045454	biological_process	cell redox homeostasis
G	0051920	molecular_function	peroxiredoxin activity
G	0070062	cellular_component	extracellular exosome
G	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
H	0002357	biological_process	defense response to tumor cell
H	0004601	molecular_function	peroxidase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006979	biological_process	response to oxidative stress
H	0008379	molecular_function	thioredoxin peroxidase activity
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0019430	biological_process	removal of superoxide radicals
H	0030194	biological_process	positive regulation of blood coagulation
H	0034599	biological_process	cellular response to oxidative stress
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0042981	biological_process	regulation of apoptotic process
H	0043066	biological_process	negative regulation of apoptotic process
H	0045321	biological_process	leukocyte activation
H	0045454	biological_process	cell redox homeostasis
H	0051920	molecular_function	peroxiredoxin activity
H	0070062	cellular_component	extracellular exosome
H	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
I	0002357	biological_process	defense response to tumor cell
I	0004601	molecular_function	peroxidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006979	biological_process	response to oxidative stress
I	0008379	molecular_function	thioredoxin peroxidase activity
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0019430	biological_process	removal of superoxide radicals
I	0030194	biological_process	positive regulation of blood coagulation
I	0034599	biological_process	cellular response to oxidative stress
I	0042744	biological_process	hydrogen peroxide catabolic process
I	0042981	biological_process	regulation of apoptotic process
I	0043066	biological_process	negative regulation of apoptotic process
I	0045321	biological_process	leukocyte activation
I	0045454	biological_process	cell redox homeostasis
I	0051920	molecular_function	peroxiredoxin activity
I	0070062	cellular_component	extracellular exosome
I	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
J	0002357	biological_process	defense response to tumor cell
J	0004601	molecular_function	peroxidase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006979	biological_process	response to oxidative stress
J	0008379	molecular_function	thioredoxin peroxidase activity
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0019430	biological_process	removal of superoxide radicals
J	0030194	biological_process	positive regulation of blood coagulation
J	0034599	biological_process	cellular response to oxidative stress
J	0042744	biological_process	hydrogen peroxide catabolic process
J	0042981	biological_process	regulation of apoptotic process
J	0043066	biological_process	negative regulation of apoptotic process
J	0045321	biological_process	leukocyte activation
J	0045454	biological_process	cell redox homeostasis
J	0051920	molecular_function	peroxiredoxin activity
J	0070062	cellular_component	extracellular exosome
J	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1580
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"11904290","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	10
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18606987","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---