7KHL
BRD4-BD1 Compound6 (methyl 4-(3,5-difluoropyridin-2-yl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-6-carboxylate)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue WEM A 201 |
| Chain | Residue |
| A | TRP81 |
| A | ASP145 |
| A | ILE146 |
| A | MET149 |
| A | HOH311 |
| A | HOH322 |
| A | HOH403 |
| B | HIS77 |
| B | ALA152 |
| B | LEU156 |
| A | PRO82 |
| A | PHE83 |
| A | GLN85 |
| A | PRO86 |
| A | VAL87 |
| A | ASP88 |
| A | LEU92 |
| A | ASN140 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 201 |
| Chain | Residue |
| B | LEU92 |
| B | LEU94 |
| B | ASN140 |
| B | HOH319 |
| B | HOH325 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA80-TYR139 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 212 |
| Details | Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Site: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
