7KHH
Ternary complex of VHL/BRD4-BD1/Compound9 (4-(3,5-difluoropyridin-2-yl)-N-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-6-carboxamide)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001222 | molecular_function | transcription corepressor binding |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006367 | biological_process | transcription initiation at RNA polymerase II promoter |
A | 0006368 | biological_process | transcription elongation by RNA polymerase II |
A | 0016567 | biological_process | protein ubiquitination |
A | 0030891 | cellular_component | VCB complex |
A | 0031462 | cellular_component | Cul2-RING ubiquitin ligase complex |
A | 0031466 | cellular_component | Cul5-RING ubiquitin ligase complex |
A | 0031625 | molecular_function | ubiquitin protein ligase binding |
A | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
A | 0065003 | biological_process | protein-containing complex assembly |
A | 0070449 | cellular_component | elongin complex |
A | 0140958 | biological_process | target-directed miRNA degradation |
B | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
Functional Information from PROSITE/UniProt
site_id | PS00633 |
Number of Residues | 60 |
Details | BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY |
Chain | Residue | Details |
D | ALA80-TYR139 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
D | ASN140 | |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
D | LYS99 | |
Chain | Residue | Details |
A | SER108 | |
A | SER111 | |