7KFI
SARS-CoV-2 Main protease immature form - apo structure
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 401 |
| Chain | Residue |
| A | GLY15 |
| A | MET17 |
| A | LYS97 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 402 |
| Chain | Residue |
| B | GLY79 |
| B | SER81 |
| B | LYS90 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 403 |
| Chain | Residue |
| A | GLN19 |
| A | LEU67 |
| A | HOH655 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 404 |
| Chain | Residue |
| A | ARG131 |
| A | LYS137 |
| A | GLU290 |
| B | ARG4 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 405 |
| Chain | Residue |
| A | SER81 |
| A | LYS90 |
| A | HOH558 |
| A | HOH631 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 406 |
| Chain | Residue |
| A | LYS5 |
| A | VAL125 |
| B | ALA7 |
| B | GLN127 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue DMS A 407 |
| Chain | Residue |
| A | ASN84 |
| A | HOH593 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 408 |
| Chain | Residue |
| A | GLN19 |
| A | GLY71 |
| A | ASN119 |
| A | GLY120 |
| A | SER121 |
| A | HOH545 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 409 |
| Chain | Residue |
| A | LEU272 |
| A | GLY275 |
| A | MET276 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 410 |
| Chain | Residue |
| A | ASP295 |
| A | HOH546 |
| B | ARG222 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue PEG B 501 |
| Chain | Residue |
| B | GLY15 |
| B | LYS97 |
| B | HOH633 |
| B | HOH643 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue DMS B 502 |
| Chain | Residue |
| A | SER123 |
| B | MET6 |
| B | PHE8 |
| B | GLN127 |
| B | ARG298 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32198291","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile; for 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32198291","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"39223933","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
