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7KFI

SARS-CoV-2 Main protease immature form - apo structure

Functional Information from GO Data
ChainGOidnamespacecontents
A0008233molecular_functionpeptidase activity
A0019082biological_processviral protein processing
B0008233molecular_functionpeptidase activity
B0019082biological_processviral protein processing
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue DMS A 401
ChainResidue
AGLY15
AMET17
ALYS97

site_idAC2
Number of Residues3
Detailsbinding site for residue PEG A 402
ChainResidue
BGLY79
BSER81
BLYS90

site_idAC3
Number of Residues3
Detailsbinding site for residue PEG A 403
ChainResidue
AGLN19
ALEU67
AHOH655

site_idAC4
Number of Residues4
Detailsbinding site for residue PEG A 404
ChainResidue
AARG131
ALYS137
AGLU290
BARG4

site_idAC5
Number of Residues4
Detailsbinding site for residue PEG A 405
ChainResidue
ASER81
ALYS90
AHOH558
AHOH631

site_idAC6
Number of Residues4
Detailsbinding site for residue DMS A 406
ChainResidue
ALYS5
AVAL125
BALA7
BGLN127

site_idAC7
Number of Residues2
Detailsbinding site for residue DMS A 407
ChainResidue
AASN84
AHOH593

site_idAC8
Number of Residues6
Detailsbinding site for residue DMS A 408
ChainResidue
AGLN19
AGLY71
AASN119
AGLY120
ASER121
AHOH545

site_idAC9
Number of Residues3
Detailsbinding site for residue DMS A 409
ChainResidue
ALEU272
AGLY275
AMET276

site_idAD1
Number of Residues3
Detailsbinding site for residue DMS A 410
ChainResidue
AASP295
AHOH546
BARG222

site_idAD2
Number of Residues4
Detailsbinding site for residue PEG B 501
ChainResidue
BGLY15
BLYS97
BHOH633
BHOH643

site_idAD3
Number of Residues5
Detailsbinding site for residue DMS B 502
ChainResidue
ASER123
BMET6
BPHE8
BGLN127
BARG298

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291
ChainResidueDetails
AHIS41
BHIS41

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291
ChainResidueDetails
ACYS145
BCYS145

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3
ChainResidueDetails
AGLN306
BGLN306

226707

PDB entries from 2024-10-30

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