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7KF8

Cryo-electron microscopy structure of the heavy metal efflux pump CusA in a heterogeneous 2 open and 1 closed protomer conformation

Functional Information from GO Data
ChainGOidnamespacecontents
A0005375molecular_functioncopper ion transmembrane transporter activity
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006812biological_processmonoatomic cation transport
A0006825biological_processcopper ion transport
A0006878biological_processintracellular copper ion homeostasis
A0008324molecular_functionmonoatomic cation transmembrane transporter activity
A0009636biological_processresponse to toxic substance
A0010272biological_processresponse to silver ion
A0010273biological_processdetoxification of copper ion
A0015080molecular_functionsilver ion transmembrane transporter activity
A0015673biological_processsilver ion transport
A0015679biological_processplasma membrane copper ion transport
A0016020cellular_componentmembrane
A0022857molecular_functiontransmembrane transporter activity
A0035434biological_processcopper ion transmembrane transport
A0042908biological_processxenobiotic transport
A0042910molecular_functionxenobiotic transmembrane transporter activity
A0046688biological_processresponse to copper ion
A0055085biological_processtransmembrane transport
A0060003biological_processcopper ion export
A1902601biological_processsilver ion transmembrane transport
B0005375molecular_functioncopper ion transmembrane transporter activity
B0005507molecular_functioncopper ion binding
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006812biological_processmonoatomic cation transport
B0006825biological_processcopper ion transport
B0006878biological_processintracellular copper ion homeostasis
B0008324molecular_functionmonoatomic cation transmembrane transporter activity
B0009636biological_processresponse to toxic substance
B0010272biological_processresponse to silver ion
B0010273biological_processdetoxification of copper ion
B0015080molecular_functionsilver ion transmembrane transporter activity
B0015673biological_processsilver ion transport
B0015679biological_processplasma membrane copper ion transport
B0016020cellular_componentmembrane
B0022857molecular_functiontransmembrane transporter activity
B0035434biological_processcopper ion transmembrane transport
B0042908biological_processxenobiotic transport
B0042910molecular_functionxenobiotic transmembrane transporter activity
B0046688biological_processresponse to copper ion
B0055085biological_processtransmembrane transport
B0060003biological_processcopper ion export
B1902601biological_processsilver ion transmembrane transport
C0005375molecular_functioncopper ion transmembrane transporter activity
C0005507molecular_functioncopper ion binding
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006812biological_processmonoatomic cation transport
C0006825biological_processcopper ion transport
C0006878biological_processintracellular copper ion homeostasis
C0008324molecular_functionmonoatomic cation transmembrane transporter activity
C0009636biological_processresponse to toxic substance
C0010272biological_processresponse to silver ion
C0010273biological_processdetoxification of copper ion
C0015080molecular_functionsilver ion transmembrane transporter activity
C0015673biological_processsilver ion transport
C0015679biological_processplasma membrane copper ion transport
C0016020cellular_componentmembrane
C0022857molecular_functiontransmembrane transporter activity
C0035434biological_processcopper ion transmembrane transport
C0042908biological_processxenobiotic transport
C0042910molecular_functionxenobiotic transmembrane transporter activity
C0046688biological_processresponse to copper ion
C0055085biological_processtransmembrane transport
C0060003biological_processcopper ion export
C1902601biological_processsilver ion transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues720
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
APHE14-THR34
ATHR928-LEU948
AALA985-GLY1005
AILE1012-PRO1032
BPHE14-THR34
BLEU338-TRP358
BALA363-PHE383
BMET391-ILE411
BVAL446-THR466
BALA485-ILE505
BVAL532-TRP552
ALEU338-TRP358
BLYS871-PHE891
BLEU898-MET918
BTHR928-LEU948
BALA985-GLY1005
BILE1012-PRO1032
CPHE14-THR34
CLEU338-TRP358
CALA363-PHE383
CMET391-ILE411
CVAL446-THR466
AALA363-PHE383
CALA485-ILE505
CVAL532-TRP552
CLYS871-PHE891
CLEU898-MET918
CTHR928-LEU948
CALA985-GLY1005
CILE1012-PRO1032
AMET391-ILE411
AVAL446-THR466
AALA485-ILE505
AVAL532-TRP552
ALYS871-PHE891
ALEU898-MET918

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PDB entries from 2024-10-30

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