7KDN

Crystal structure of Acetyl-CoA Synthetase in Complex with Adenosine-5'-propylphosphate from Aspergillus fumigatus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003987	molecular_function	acetate-CoA ligase activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006085	biological_process	acetyl-CoA biosynthetic process
A	0016208	molecular_function	AMP binding
A	0016874	molecular_function	ligase activity
A	0019427	biological_process	acetyl-CoA biosynthetic process from acetate
B	0000166	molecular_function	nucleotide binding
B	0003987	molecular_function	acetate-CoA ligase activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006085	biological_process	acetyl-CoA biosynthetic process
B	0016208	molecular_function	AMP binding
B	0016874	molecular_function	ligase activity
B	0019427	biological_process	acetyl-CoA biosynthetic process from acetate
C	0000166	molecular_function	nucleotide binding
C	0003987	molecular_function	acetate-CoA ligase activity
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0006085	biological_process	acetyl-CoA biosynthetic process
C	0016208	molecular_function	AMP binding
C	0016874	molecular_function	ligase activity
C	0019427	biological_process	acetyl-CoA biosynthetic process from acetate
D	0000166	molecular_function	nucleotide binding
D	0003987	molecular_function	acetate-CoA ligase activity
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0006085	biological_process	acetyl-CoA biosynthetic process
D	0016208	molecular_function	AMP binding
D	0016874	molecular_function	ligase activity
D	0019427	biological_process	acetyl-CoA biosynthetic process from acetate
E	0000166	molecular_function	nucleotide binding
E	0003987	molecular_function	acetate-CoA ligase activity
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0006085	biological_process	acetyl-CoA biosynthetic process
E	0016208	molecular_function	AMP binding
E	0016874	molecular_function	ligase activity
E	0019427	biological_process	acetyl-CoA biosynthetic process from acetate
F	0000166	molecular_function	nucleotide binding
F	0003987	molecular_function	acetate-CoA ligase activity
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0006085	biological_process	acetyl-CoA biosynthetic process
F	0016208	molecular_function	AMP binding
F	0016874	molecular_function	ligase activity
F	0019427	biological_process	acetyl-CoA biosynthetic process from acetate

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue PRX A 701

Chain	Residue
A	GLY404
A	ASP519
A	ILE531
A	ARG534
A	ARG545
A	GLU405
A	PRO406
A	ASP428
A	THR429
A	TYR430
A	TRP431
A	GLN432
A	THR433

---

site_id	AC2
Number of Residues	12
Details	binding site for residue PRX B 701

Chain	Residue
B	GLY404
B	GLU405
B	PRO406
B	ASP428
B	THR429
B	TRP431
B	GLN432
B	THR433
B	ASP519
B	ILE531
B	ARG545
B	HOH806

---

site_id	AC3
Number of Residues	12
Details	binding site for residue PRX C 701

Chain	Residue
C	VAL403
C	GLY404
C	GLU405
C	PRO406
C	ASP428
C	THR429
C	TYR430
C	TRP431
C	GLN432
C	THR433
C	ASP519
C	ILE531

---

site_id	AC4
Number of Residues	12
Details	binding site for residue PRX D 701

Chain	Residue
D	ILE328
D	GLY404
D	GLU405
D	PRO406
D	ASP428
D	THR429
D	TYR430
D	TRP431
D	GLN432
D	THR433
D	ASP519
D	ILE531

---

site_id	AC5
Number of Residues	14
Details	binding site for residue PRX E 701

Chain	Residue
E	VAL403
E	GLY404
E	GLU405
E	PRO406
E	ASP428
E	THR429
E	TYR430
E	TRP431
E	GLN432
E	THR433
E	ASP519
E	ILE531
E	ARG534
E	ARG545

---

site_id	AC6
Number of Residues	11
Details	binding site for residue PRX F 701

Chain	Residue
F	GLY404
F	GLU405
F	PRO406
F	ASP428
F	THR429
F	TYR430
F	TRP431
F	GLN432
F	THR433
F	ASP519
F	ARG545

---

Functional Information from PROSITE/UniProt

site_id	PS00455
Number of Residues	12
Details	AMP_BINDING Putative AMP-binding domain signature. LLYTSGSTGkPK

Chain	Residue	Details
A	LEU279-LYS290

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