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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7KCB

Symmetry in Yeast Alcohol Dehydrogenase 1 -Closed Form with NAD+ and Trifluoroethanol

Functional Information from GO Data
ChainGOidnamespacecontents
A0000947biological_processamino acid catabolic process to alcohol via Ehrlich pathway
A0004022molecular_functionalcohol dehydrogenase (NAD+) activity
A0004552molecular_functionoctanol dehydrogenase (NAD+) activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0008270molecular_functionzinc ion binding
A0016491molecular_functionoxidoreductase activity
A0019170molecular_functionmethylglyoxal reductase (NADH) activity
A0019655biological_processpyruvate fermentation to ethanol
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
A0047655molecular_functionallyl-alcohol dehydrogenase activity
A0120542molecular_functionethanol dehydrogenase (NAD+) activity
A1904408molecular_functionmelatonin binding
A1990362molecular_functionbutanol dehydrogenase (NAD+) activity
B0000947biological_processamino acid catabolic process to alcohol via Ehrlich pathway
B0004022molecular_functionalcohol dehydrogenase (NAD+) activity
B0004552molecular_functionoctanol dehydrogenase (NAD+) activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0008270molecular_functionzinc ion binding
B0016491molecular_functionoxidoreductase activity
B0019170molecular_functionmethylglyoxal reductase (NADH) activity
B0019655biological_processpyruvate fermentation to ethanol
B0042802molecular_functionidentical protein binding
B0046872molecular_functionmetal ion binding
B0047655molecular_functionallyl-alcohol dehydrogenase activity
B0120542molecular_functionethanol dehydrogenase (NAD+) activity
B1904408molecular_functionmelatonin binding
B1990362molecular_functionbutanol dehydrogenase (NAD+) activity
C0000947biological_processamino acid catabolic process to alcohol via Ehrlich pathway
C0004022molecular_functionalcohol dehydrogenase (NAD+) activity
C0004552molecular_functionoctanol dehydrogenase (NAD+) activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0008270molecular_functionzinc ion binding
C0016491molecular_functionoxidoreductase activity
C0019170molecular_functionmethylglyoxal reductase (NADH) activity
C0019655biological_processpyruvate fermentation to ethanol
C0042802molecular_functionidentical protein binding
C0046872molecular_functionmetal ion binding
C0047655molecular_functionallyl-alcohol dehydrogenase activity
C0120542molecular_functionethanol dehydrogenase (NAD+) activity
C1904408molecular_functionmelatonin binding
C1990362molecular_functionbutanol dehydrogenase (NAD+) activity
D0000947biological_processamino acid catabolic process to alcohol via Ehrlich pathway
D0004022molecular_functionalcohol dehydrogenase (NAD+) activity
D0004552molecular_functionoctanol dehydrogenase (NAD+) activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0008270molecular_functionzinc ion binding
D0016491molecular_functionoxidoreductase activity
D0019170molecular_functionmethylglyoxal reductase (NADH) activity
D0019655biological_processpyruvate fermentation to ethanol
D0042802molecular_functionidentical protein binding
D0046872molecular_functionmetal ion binding
D0047655molecular_functionallyl-alcohol dehydrogenase activity
D0120542molecular_functionethanol dehydrogenase (NAD+) activity
D1904408molecular_functionmelatonin binding
D1990362molecular_functionbutanol dehydrogenase (NAD+) activity
Functional Information from PROSITE/UniProt
site_idPS00059
Number of Residues15
DetailsADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEgAGVvvgmGenV
ChainResidueDetails
AGLY65-VAL79
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25157460","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26743849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4W6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ENV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues56
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26743849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ENV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"description":"in the open conformation","evidences":[{"source":"PubMed","id":"25157460","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26743849","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4W6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ENV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"320000","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues20
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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