7K8E
Beta-lactamase mixed with Ceftriaxone, 5ms
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005576 | cellular_component | extracellular region |
A | 0005886 | cellular_component | plasma membrane |
A | 0008800 | molecular_function | beta-lactamase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0017001 | biological_process | antibiotic catabolic process |
A | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
A | 0033250 | molecular_function | penicillinase activity |
A | 0033251 | molecular_function | cephalosporinase activity |
A | 0042597 | cellular_component | periplasmic space |
A | 0046677 | biological_process | response to antibiotic |
B | 0005576 | cellular_component | extracellular region |
B | 0005886 | cellular_component | plasma membrane |
B | 0008800 | molecular_function | beta-lactamase activity |
B | 0016787 | molecular_function | hydrolase activity |
B | 0017001 | biological_process | antibiotic catabolic process |
B | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
B | 0033250 | molecular_function | penicillinase activity |
B | 0033251 | molecular_function | cephalosporinase activity |
B | 0042597 | cellular_component | periplasmic space |
B | 0046677 | biological_process | response to antibiotic |
C | 0005576 | cellular_component | extracellular region |
C | 0005886 | cellular_component | plasma membrane |
C | 0008800 | molecular_function | beta-lactamase activity |
C | 0016787 | molecular_function | hydrolase activity |
C | 0017001 | biological_process | antibiotic catabolic process |
C | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
C | 0033250 | molecular_function | penicillinase activity |
C | 0033251 | molecular_function | cephalosporinase activity |
C | 0042597 | cellular_component | periplasmic space |
C | 0046677 | biological_process | response to antibiotic |
D | 0005576 | cellular_component | extracellular region |
D | 0005886 | cellular_component | plasma membrane |
D | 0008800 | molecular_function | beta-lactamase activity |
D | 0016787 | molecular_function | hydrolase activity |
D | 0017001 | biological_process | antibiotic catabolic process |
D | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
D | 0033250 | molecular_function | penicillinase activity |
D | 0033251 | molecular_function | cephalosporinase activity |
D | 0042597 | cellular_component | periplasmic space |
D | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue PO4 A 301 |
Chain | Residue |
A | SER70 |
A | SER128 |
A | THR218 |
A | THR237 |
A | GLY238 |
A | THR239 |
B | GLN109 |
site_id | AC2 |
Number of Residues | 18 |
Details | binding site for residue 9F2 B 301 |
Chain | Residue |
B | SER70 |
B | SER128 |
B | PRO169 |
B | ASN172 |
B | ARG173 |
B | ARG222 |
B | LYS236 |
B | THR237 |
B | GLY238 |
B | THR239 |
B | GLY240 |
B | GLU278 |
B | PO4302 |
B | HOH401 |
B | HOH412 |
B | HOH413 |
A | GLN109 |
B | CYS69 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue PO4 B 302 |
Chain | Residue |
B | SER70 |
B | SER128 |
B | LYS236 |
B | THR237 |
B | THR239 |
B | 9F2301 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue PO4 C 301 |
Chain | Residue |
C | SER70 |
C | SER128 |
C | THR237 |
C | GLY238 |
C | THR239 |
site_id | AC5 |
Number of Residues | 14 |
Details | binding site for residue 9F2 D 301 |
Chain | Residue |
C | GLN109 |
D | SER70 |
D | SER128 |
D | PRO169 |
D | ASN172 |
D | ARG173 |
D | LYS236 |
D | THR237 |
D | GLY238 |
D | THR239 |
D | GLY240 |
D | PO4302 |
D | HOH412 |
D | HOH416 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue PO4 D 302 |
Chain | Residue |
D | SER70 |
D | SER128 |
D | THR237 |
D | GLY238 |
D | THR239 |
D | 9F2301 |
Functional Information from PROSITE/UniProt
site_id | PS00146 |
Number of Residues | 16 |
Details | BETA_LACTAMASE_A Beta-lactamase class-A active site. FaFCSTfKaplVAAVL |
Chain | Residue | Details |
A | PHE66-LEU81 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Acyl-ester intermediate => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112 |
Chain | Residue | Details |
A | SER70 | |
B | SER70 | |
C | SER70 | |
D | SER70 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112 |
Chain | Residue | Details |
A | GLU168 | |
B | GLU168 | |
C | GLU168 | |
D | GLU168 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112 |
Chain | Residue | Details |
A | SER128 | |
C | SER128 | |
C | THR237 | |
D | SER128 | |
D | THR237 | |
A | THR237 | |
B | SER128 | |
B | THR237 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | SITE: Increases nucleophilicity of active site Ser => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112 |
Chain | Residue | Details |
A | LYS73 | |
B | LYS73 | |
C | LYS73 | |
D | LYS73 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | SITE: Functions as a gatekeeper residue that regulates substrate accessibility to the enzyme active site => ECO:0000303|PubMed:24023821 |
Chain | Residue | Details |
A | ILE103 | |
B | ILE103 | |
C | ILE103 | |
D | ILE103 |