7K8B
CryoEM structure of a trehalose monomycolate transporter in lipid nanodiscs
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006869 | biological_process | lipid transport |
| A | 0008429 | molecular_function | phosphatidylethanolamine binding |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0015574 | molecular_function | trehalose transmembrane transporter activity |
| A | 0015771 | biological_process | trehalose transport |
| A | 0015914 | biological_process | phospholipid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0019992 | molecular_function | diacylglycerol binding |
| A | 0030428 | cellular_component | cell septum |
| A | 0035091 | molecular_function | phosphatidylinositol binding |
| A | 0042391 | biological_process | regulation of membrane potential |
| A | 0042546 | biological_process | cell wall biogenesis |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0051286 | cellular_component | cell tip |
| A | 0060187 | cellular_component | cell pole |
| A | 0071555 | biological_process | cell wall organization |
| A | 0071768 | biological_process | mycolic acid biosynthetic process |
| A | 0071769 | biological_process | mycolate cell wall layer assembly |
| A | 0120009 | biological_process | intermembrane lipid transfer |
| A | 1901611 | molecular_function | phosphatidylglycerol binding |
| A | 1901612 | molecular_function | cardiolipin binding |
| A | 1904121 | molecular_function | phosphatidylethanolamine transfer activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 419 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:30682372, ECO:0000305|PubMed:31113875 |
| Chain | Residue | Details |
| A | MET1-TYR14 | |
| A | VAL262-VAL290 | |
| A | ALA339-PRO401 | |
| A | PRO589-LYS591 | |
| A | SER652-LEU678 | |
| A | PRO725-LEU1013 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE15-GLY35 | |
| A | VAL197-ILE217 | |
| A | GLY218-VAL238 | |
| A | PHE241-ILE261 | |
| A | VAL291-PHE311 | |
| A | ALA318-LEU338 | |
| A | ILE402-LEU422 | |
| A | ALA568-LEU588 | |
| A | ALA592-VAL612 | |
| A | MET631-VAL651 | |
| A | ILE679-VAL699 | |
| A | LEU704-VAL724 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 330 |
| Details | TOPO_DOM: Periplasmic => ECO:0000305|PubMed:30682372, ECO:0000305|PubMed:31113875 |
| Chain | Residue | Details |
| A | ASN36-LEU196 | |
| A | HIS239-PHE240 | |
| A | LEU312-TYR317 | |
| A | SER423-MET567 | |
| A | ASP613-PRO630 | |
| A | MET700-TYR703 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31113875, ECO:0007744|PDB:6OR2 |
| Chain | Residue | Details |
| A | GLN40 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30682372, ECO:0007744|PDB:6AJG |
| Chain | Residue | Details |
| A | ASP645 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | SITE: Part of the proton-transportation channel => ECO:0000305|PubMed:30682372, ECO:0000305|PubMed:31113875 |
| Chain | Residue | Details |
| A | TYR646 | |
| A | ASP256 | |
| A | TYR257 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Part of the proton transportation network => ECO:0000305|PubMed:31113875 |
| Chain | Residue | Details |
| A | GLU647 | |
| A | LYS591 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | SITE: Part of the proton-transportation channel => ECO:0000305|PubMed:30682372, ECO:0000305|PubMed:31113875, ECO:0000305|PubMed:32512002 |
| Chain | Residue | Details |
| A | ASP645 |
