7K7Y

Crystal structure of BoNT/E LC-HN domain in complex with VHH JLE-E9

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding
A	0008320	molecular_function	protein transmembrane transporter activity
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008270	molecular_function	zinc ion binding
B	0008320	molecular_function	protein transmembrane transporter activity
E	0004222	molecular_function	metalloendopeptidase activity
E	0006508	biological_process	proteolysis
E	0008270	molecular_function	zinc ion binding
E	0008320	molecular_function	protein transmembrane transporter activity
G	0004222	molecular_function	metalloendopeptidase activity
G	0006508	biological_process	proteolysis
G	0008270	molecular_function	zinc ion binding
G	0008320	molecular_function	protein transmembrane transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLMHELIHSL

Chain	Residue	Details
A	THR209-LEU218

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15157097","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"1T3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZKX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZN3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FFZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"1T3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZKX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZN3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FFZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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