7K7Y
Crystal structure of BoNT/E LC-HN domain in complex with VHH JLE-E9
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008320 | molecular_function | protein transmembrane transporter activity |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008320 | molecular_function | protein transmembrane transporter activity |
| E | 0004222 | molecular_function | metalloendopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0008320 | molecular_function | protein transmembrane transporter activity |
| G | 0004222 | molecular_function | metalloendopeptidase activity |
| G | 0006508 | biological_process | proteolysis |
| G | 0008270 | molecular_function | zinc ion binding |
| G | 0008320 | molecular_function | protein transmembrane transporter activity |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLMHELIHSL |
| Chain | Residue | Details |
| A | THR209-LEU218 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000305|PubMed:15157097 |
| Chain | Residue | Details |
| A | GLU213 | |
| E | GLU213 | |
| G | GLU213 | |
| B | GLU213 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0007744|PDB:1T3A, ECO:0007744|PDB:1T3C, ECO:0007744|PDB:1ZKW, ECO:0007744|PDB:1ZKX, ECO:0007744|PDB:1ZL6, ECO:0007744|PDB:1ZN3, ECO:0007744|PDB:3FFZ |
| Chain | Residue | Details |
| A | HIS212 | |
| A | HIS216 | |
| E | HIS212 | |
| E | HIS216 | |
| G | HIS212 | |
| G | HIS216 | |
| B | HIS212 | |
| B | HIS216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1T3A, ECO:0007744|PDB:1T3C, ECO:0007744|PDB:1ZKW, ECO:0007744|PDB:1ZKX, ECO:0007744|PDB:1ZL6, ECO:0007744|PDB:1ZN3, ECO:0007744|PDB:3FFZ |
| Chain | Residue | Details |
| A | GLU251 | |
| E | GLU251 | |
| G | GLU251 | |
| B | GLU251 |
