7K73

Structure of Enoyl-[acyl-carrier-protein] reductase [NADH] from Mycobacterium fortuitum bound to NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
C	0000166	molecular_function	nucleotide binding
C	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
E	0000166	molecular_function	nucleotide binding
E	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
G	0000166	molecular_function	nucleotide binding
G	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G	0006629	biological_process	lipid metabolic process
G	0006631	biological_process	fatty acid metabolic process
G	0006633	biological_process	fatty acid biosynthetic process
G	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	35
Details	binding site for residue NAD A 301

Chain	Residue
A	GLY14
A	SER94
A	ILE95
A	GLY96
A	ILE122
A	MET147
A	ASP148
A	PHE149
A	LYS165
A	ALA191
A	PRO193
A	ILE15
A	ILE194
A	THR196
A	LEU197
A	ALA198
A	MET199
A	ACT303
A	HOH424
A	HOH440
A	HOH467
A	HOH488
A	ILE16
A	HOH522
A	HOH535
A	HOH583
A	HOH596
A	HOH601
A	HOH619
A	SER20
A	ILE21
A	PHE41
A	LEU63
A	ASP64
A	VAL65

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 302

Chain	Residue
A	HIS70
A	ARG77
A	HOH442
A	HOH490

---

site_id	AC3
Number of Residues	3
Details	binding site for residue ACT A 303

Chain	Residue
A	MET161
A	NAD301
A	HOH427

---

site_id	AC4
Number of Residues	7
Details	binding site for residue EDO A 304

Chain	Residue
A	GLU68
A	TYR125
A	LYS132
A	HOH515
G	PHE109
G	ASP110
G	ALA111

---

site_id	AC5
Number of Residues	36
Details	binding site for residue NAD C 301

Chain	Residue
C	GLY14
C	ILE15
C	ILE16
C	SER20
C	ILE21
C	PHE41
C	LEU63
C	ASP64
C	VAL65
C	SER94
C	ILE95
C	GLY96
C	ILE122
C	MET147
C	ASP148
C	PHE149
C	LYS165
C	ALA191
C	GLY192
C	PRO193
C	ILE194
C	THR196
C	LEU197
C	ALA198
C	MET199
C	ACT304
C	HOH407
C	HOH424
C	HOH456
C	HOH468
C	HOH497
C	HOH511
C	HOH578
C	HOH580
C	HOH587
C	HOH621

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO C 302

Chain	Residue
C	PHE109
C	ASP110
C	HOH579
E	GLU68
E	LYS132

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO C 303

Chain	Residue
C	GLU62
C	HIS70
C	ARG77
C	HOH527
C	HOH567

---

site_id	AC8
Number of Residues	5
Details	binding site for residue ACT C 304

Chain	Residue
C	HOH469
C	PHE149
C	MET161
C	MET199
C	NAD301

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO C 305

Chain	Residue
C	GLU68
C	LYS132
C	HOH444
E	PHE109
E	ASP110

---

site_id	AD1
Number of Residues	34
Details	binding site for residue NAD E 301

Chain	Residue
E	GLY14
E	ILE15
E	ILE16
E	SER20
E	ILE21
E	PHE41
E	LEU63
E	ASP64
E	VAL65
E	SER94
E	ILE95
E	GLY96
E	ILE122
E	MET147
E	ASP148
E	PHE149
E	LYS165
E	ALA191
E	PRO193
E	ILE194
E	THR196
E	LEU197
E	ALA198
E	ACT303
E	HOH408
E	HOH438
E	HOH451
E	HOH452
E	HOH467
E	HOH507
E	HOH521
E	HOH529
E	HOH549
E	HOH561

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO E 302

Chain	Residue
E	HIS70
E	ARG77
E	HOH429
E	HOH477
E	HOH515

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ACT E 303

Chain	Residue
E	PHE149
E	ILE202
E	NAD301
E	HOH490

---

site_id	AD4
Number of Residues	8
Details	binding site for residue EDO G 401

Chain	Residue
A	PHE109
A	ASP110
A	ALA111
G	GLU68
G	TYR125
G	LYS132
G	HOH508
G	HOH617

---

site_id	AD5
Number of Residues	36
Details	binding site for residue NAD G 402

Chain	Residue
G	GLY14
G	ILE15
G	ILE16
G	SER20
G	ILE21
G	PHE41
G	LEU63
G	ASP64
G	VAL65
G	SER94
G	ILE95
G	GLY96
G	ILE122
G	MET147
G	ASP148
G	PHE149
G	LYS165
G	ALA191
G	GLY192
G	PRO193
G	ILE194
G	THR196
G	LEU197
G	ALA198
G	MET199
G	ACT404
G	HOH509
G	HOH532
G	HOH535
G	HOH543
G	HOH547
G	HOH567
G	HOH618
G	HOH647
G	HOH664
G	HOH670

---

site_id	AD6
Number of Residues	5
Details	binding site for residue EDO G 403

Chain	Residue
G	GLU62
G	HIS70
G	ARG77
G	HOH529
G	HOH570

---

site_id	AD7
Number of Residues	3
Details	binding site for residue ACT G 404

Chain	Residue
G	PHE149
G	NAD402
G	HOH511

---