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7K6G

Crystal structure of the first bromodomain (BD1) of human BRD4 bound to ERK5-IN-1

Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue VYJ A 201
ChainResidue
ATYR139
BMET149
AASN140
AVYJ202
AVYJ203
AEDO204
AHOH372
AHOH403
BPHE79
BTRP81

site_idAC2
Number of Residues13
Detailsbinding site for residue VYJ A 202
ChainResidue
APHE79
ATRP81
AASP145
AMET149
AVYJ201
AEDO204
AHOH344
AHOH406
BTRP81
BTYR139
BASN140
BVYJ201
BHOH378

site_idAC3
Number of Residues12
Detailsbinding site for residue VYJ A 203
ChainResidue
ATRP81
APRO82
ALEU92
ALEU94
AASN140
AILE146
AVYJ201
AHOH332
AHOH349
AHOH365
BGLN78
BHOH324

site_idAC4
Number of Residues3
Detailsbinding site for residue EDO A 204
ChainResidue
AVYJ201
AVYJ202
AHOH314

site_idAC5
Number of Residues6
Detailsbinding site for residue EDO A 205
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH329

site_idAC6
Number of Residues15
Detailsbinding site for residue VYJ B 201
ChainResidue
AGLN78
AVYJ202
AHOH302
BTRP81
BPRO82
BPHE83
BGLN85
BLEU92
BASN140
BILE146
BHOH326
BHOH329
BHOH340
BHOH370
BHOH382

site_idAC7
Number of Residues5
Detailsbinding site for residue EDO B 202
ChainResidue
BILE100
BILE101
BLYS102
BTHR103
BASN135

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues212
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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