Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 37 |
Details | binding site for residue NAP A 201 |
Chain | Residue |
A | TRP8 |
A | ARG46 |
A | ARG47 |
A | THR48 |
A | VAL67 |
A | THR68 |
A | ARG69 |
A | GLN70 |
A | GLY82 |
A | ILE100 |
A | GLY102 |
A | ALA9 |
A | ALA103 |
A | GLN104 |
A | ILE105 |
A | TYR106 |
A | LEU108 |
A | VY7202 |
A | HOH322 |
A | HOH328 |
A | HOH343 |
A | HOH345 |
A | ILE16 |
A | HOH350 |
A | HOH367 |
A | HOH372 |
A | HOH386 |
A | HOH389 |
A | HOH397 |
A | HOH406 |
A | HOH412 |
A | GLY17 |
A | ARG18 |
A | GLY20 |
A | GLY21 |
A | ILE22 |
A | GLY45 |
site_id | AC2 |
Number of Residues | 22 |
Details | binding site for residue VY7 A 202 |
Chain | Residue |
A | ILE7 |
A | TRP8 |
A | ALA9 |
A | ILE22 |
A | LEU26 |
A | ASP29 |
A | LEU30 |
A | PHE33 |
A | LYS34 |
A | PRO53 |
A | HIS56 |
A | LEU59 |
A | ARG62 |
A | ILE100 |
A | TYR106 |
A | NAP201 |
A | HOH301 |
A | HOH304 |
A | HOH314 |
A | HOH327 |
A | HOH380 |
A | HOH401 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue SER A 203 |
Chain | Residue |
A | GLU120 |
A | HIS160 |
A | TYR162 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGrdggIPWrlpe.DlahFkrlT |
Chain | Residue | Details |
A | VAL15-THR37 | |