7K5K

Plasmodium vivax M17 leucyl aminopeptidase Pv-M17

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0019538	biological_process	protein metabolic process
A	0030145	molecular_function	manganese ion binding
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0019538	biological_process	protein metabolic process
B	0030145	molecular_function	manganese ion binding
B	0046872	molecular_function	metal ion binding
B	0070006	molecular_function	metalloaminopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0019538	biological_process	protein metabolic process
C	0030145	molecular_function	manganese ion binding
C	0046872	molecular_function	metal ion binding
C	0070006	molecular_function	metalloaminopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0019538	biological_process	protein metabolic process
D	0030145	molecular_function	manganese ion binding
D	0046872	molecular_function	metal ion binding
D	0070006	molecular_function	metalloaminopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0019538	biological_process	protein metabolic process
E	0030145	molecular_function	manganese ion binding
E	0046872	molecular_function	metal ion binding
E	0070006	molecular_function	metalloaminopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0019538	biological_process	protein metabolic process
F	0030145	molecular_function	manganese ion binding
F	0046872	molecular_function	metal ion binding
F	0070006	molecular_function	metalloaminopeptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00631
Number of Residues	8
Details	CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL

Chain	Residue	Details
A	ASN473-LEU480

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P00727

Chain	Residue	Details
A	LYS402
E	ARG479
F	LYS402
F	ARG479
A	ARG479
B	LYS402
B	ARG479
C	LYS402
C	ARG479
D	LYS402
D	ARG479
E	LYS402

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site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:33303633, ECO:0000312|PDB:7K5K, ECO:0007744|PDB:6WVV

Chain	Residue	Details
A	LYS390
C	ASP395
C	ASP475
C	GLU477
D	LYS390
D	ASP395
D	ASP475
D	GLU477
E	LYS390
E	ASP395
E	ASP475
A	ASP395
E	GLU477
F	LYS390
F	ASP395
F	ASP475
F	GLU477
A	ASP475
A	GLU477
B	LYS390
B	ASP395
B	ASP475
B	GLU477
C	LYS390

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site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q8IL11

Chain	Residue	Details
A	LYS402
C	ASP410
C	MET412
C	ASP415
D	LYS402
D	ASP410
D	MET412
D	ASP415
E	LYS402
E	ASP410
E	MET412
A	ASP410
E	ASP415
F	LYS402
F	ASP410
F	MET412
F	ASP415
A	MET412
A	ASP415
B	LYS402
B	ASP410
B	MET412
B	ASP415
C	LYS402

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site_id	SWS_FT_FI4
Number of Residues	6
Details	SITE: Essential for hexamer stabilization => ECO:0000250|UniProtKB:Q8IL11

Chain	Residue	Details
A	ALA386
B	ALA386
C	ALA386
D	ALA386
E	ALA386
F	ALA386

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