7K1O
Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-3',5'-Diphosphate
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | binding site for residue VQV A 401 |
Chain | Residue |
A | HIS235 |
A | GLY247 |
A | GLY248 |
A | HIS250 |
A | LYS290 |
A | TRP333 |
A | THR341 |
A | EDO402 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue EDO A 402 |
Chain | Residue |
A | VAL292 |
A | CYS293 |
A | SER294 |
A | TYR343 |
A | VQV401 |
A | HIS250 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue VQV B 401 |
Chain | Residue |
B | HIS235 |
B | GLY248 |
B | HIS250 |
B | LYS290 |
B | TRP333 |
B | GLU340 |
B | THR341 |
B | EDO402 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue EDO B 402 |
Chain | Residue |
B | HIS250 |
B | LYS290 |
B | VAL292 |
B | SER294 |
B | VQV401 |
site_id | AC5 |
Number of Residues | 10 |
Details | binding site for residue VQV C 401 |
Chain | Residue |
C | HIS235 |
C | GLN245 |
C | GLY247 |
C | GLY248 |
C | HIS250 |
C | LYS290 |
C | TRP333 |
C | GLU340 |
C | THR341 |
C | EDO402 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue EDO C 402 |
Chain | Residue |
C | HIS250 |
C | VAL292 |
C | CYS293 |
C | SER294 |
C | TYR343 |
C | VQV401 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 180 |
Details | Domain: {"description":"Nsp15 N-terminal oligomerization","evidences":[{"source":"PROSITE-ProRule","id":"PRU01305","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 375 |
Details | Domain: {"description":"AV-Nsp11N/CoV-Nsp15M","evidences":[{"source":"PROSITE-ProRule","id":"PRU01306","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 417 |
Details | Domain: {"description":"NendoU","evidences":[{"source":"PROSITE-ProRule","id":"PRU01303","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | Active site: {"description":"Proton donor; for uridylate-specific endoribonuclease nsp15 activity","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | Active site: {"description":"Proton acceptor; for uridylate-specific endoribonuclease nsp15 activity","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | Active site: {"description":"For uridylate-specific endoribonuclease nsp15 activity","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 12 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI8 |
Number of Residues | 12 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI9 |
Number of Residues | 3 |
Details | Site: {"description":"Cleavage; by 3CL-PRO","evidences":[{"source":"UniProtKB","id":"P0C6V3","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI10 |
Number of Residues | 3 |
Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI11 |
Number of Residues | 3 |
Details | Site: {"description":"Uracil recognition site","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |