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7K1B

CryoEM structure of DNA-PK catalytic subunit complexed with DNA (Complex II)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000460biological_processmaturation of 5.8S rRNA
A0000723biological_processtelomere maintenance
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0001756biological_processsomitogenesis
A0001933biological_processnegative regulation of protein phosphorylation
A0002218biological_processactivation of innate immune response
A0002326biological_processB cell lineage commitment
A0002327biological_processimmature B cell differentiation
A0002328biological_processpro-B cell differentiation
A0002360biological_processT cell lineage commitment
A0003677molecular_functionDNA binding
A0003690molecular_functiondouble-stranded DNA binding
A0003723molecular_functionRNA binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004677molecular_functionDNA-dependent protein kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005667cellular_componenttranscription regulator complex
A0005730cellular_componentnucleolus
A0005829cellular_componentcytosol
A0005958cellular_componentDNA-dependent protein kinase-DNA ligase 4 complex
A0006281biological_processDNA repair
A0006302biological_processdouble-strand break repair
A0006303biological_processdouble-strand break repair via nonhomologous end joining
A0006310biological_processDNA recombination
A0006338biological_processchromatin remodeling
A0006468biological_processprotein phosphorylation
A0006974biological_processDNA damage response
A0007420biological_processbrain development
A0007507biological_processheart development
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0010212biological_processresponse to ionizing radiation
A0010332biological_processresponse to gamma radiation
A0016020cellular_componentmembrane
A0016233biological_processtelomere capping
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0019219biological_processregulation of nucleobase-containing compound metabolic process
A0019899molecular_functionenzyme binding
A0019904molecular_functionprotein domain specific binding
A0030098biological_processlymphocyte differentiation
A0031571biological_processmitotic G1 DNA damage checkpoint signaling
A0031648biological_processprotein destabilization
A0032040cellular_componentsmall-subunit processome
A0032869biological_processcellular response to insulin stimulus
A0032991cellular_componentprotein-containing complex
A0032993cellular_componentprotein-DNA complex
A0033077biological_processT cell differentiation in thymus
A0033151biological_processV(D)J recombination
A0033152biological_processimmunoglobulin V(D)J recombination
A0033153biological_processT cell receptor V(D)J recombination
A0034462biological_processsmall-subunit processome assembly
A0034511molecular_functionU3 snoRNA binding
A0035234biological_processectopic germ cell programmed cell death
A0035979molecular_functionhistone H2AXS139 kinase activity
A0036211biological_processprotein modification process
A0042254biological_processribosome biogenesis
A0042752biological_processregulation of circadian rhythm
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0044024molecular_functionhistone H2AS1 kinase activity
A0045087biological_processinnate immune response
A0045621biological_processpositive regulation of lymphocyte differentiation
A0045648biological_processpositive regulation of erythrocyte differentiation
A0045727biological_processpositive regulation of translation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048511biological_processrhythmic process
A0048660biological_processregulation of smooth muscle cell proliferation
A0050678biological_processregulation of epithelial cell proliferation
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070418cellular_componentDNA-dependent protein kinase complex
A0070419cellular_componentnonhomologous end joining complex
A0080135biological_processregulation of cellular response to stress
A0097681biological_processdouble-strand break repair via alternative nonhomologous end joining
A0106310molecular_functionprotein serine kinase activity
A0160049biological_processnegative regulation of cGAS/STING signaling pathway
A1902036biological_processregulation of hematopoietic stem cell differentiation
A1905221biological_processpositive regulation of platelet formation
A2001034biological_processpositive regulation of double-strand break repair via nonhomologous end joining
Functional Information from PROSITE/UniProt
site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKgg.EDLRQDqrveQ
ChainResidueDetails
AVAL3752-GLN3766

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ShAlicIshWILgIgDRHlnN
ChainResidueDetails
ASER3907-ASN3927

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by caspase-3 => ECO:0000269|PubMed:8804412
ChainResidueDetails
AASP2020

site_idSWS_FT_FI2
Number of Residues10
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS117
ALYS3642
ALYS828
ALYS1209
ALYS1970
ALYS2259
ALYS3241
ALYS3260
ALYS3621
ALYS3638

site_idSWS_FT_FI3
Number of Residues7
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER511
ASER687
ASER841
ASER1065
ASER2789
ASER3731
ASER3821

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ASER893

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:34352203
ChainResidueDetails
ASER2056

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR2535

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:12186630, ECO:0000269|PubMed:12231622, ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:32103174, ECO:0000269|PubMed:34352203
ChainResidueDetails
ATHR2609

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:12186630, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER2612

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:12186630, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR2638
ATHR2647

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER3205

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER4026

226707

PDB entries from 2024-10-30

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