7K0R
Nucleotide bound SARS-CoV-2 Nsp15
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue U5P A 401 |
| Chain | Residue |
| A | HIS250 |
| A | LYS290 |
| A | VAL292 |
| A | CYS293 |
| A | SER294 |
| A | PO4402 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 402 |
| Chain | Residue |
| A | HIS250 |
| A | LYS290 |
| A | THR341 |
| A | U5P401 |
| A | HIS235 |
| A | GLY247 |
| A | GLY248 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue U5P B 401 |
| Chain | Residue |
| B | HIS250 |
| B | LYS290 |
| B | VAL292 |
| B | CYS293 |
| B | SER294 |
| B | PO4402 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 B 402 |
| Chain | Residue |
| B | HIS235 |
| B | GLY247 |
| B | GLY248 |
| B | HIS250 |
| B | LYS290 |
| B | THR341 |
| B | U5P401 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue U5P C 401 |
| Chain | Residue |
| C | HIS250 |
| C | LYS290 |
| C | VAL292 |
| C | CYS293 |
| C | SER294 |
| C | PO4402 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 C 402 |
| Chain | Residue |
| C | HIS235 |
| C | GLY247 |
| C | GLY248 |
| C | HIS250 |
| C | LYS290 |
| C | THR341 |
| C | U5P401 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue U5P D 401 |
| Chain | Residue |
| D | HIS250 |
| D | LYS290 |
| D | VAL292 |
| D | CYS293 |
| D | SER294 |
| D | PO4402 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 D 402 |
| Chain | Residue |
| D | HIS235 |
| D | GLY247 |
| D | GLY248 |
| D | HIS250 |
| D | LYS290 |
| D | THR341 |
| D | U5P401 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue U5P E 401 |
| Chain | Residue |
| E | HIS250 |
| E | LYS290 |
| E | VAL292 |
| E | CYS293 |
| E | SER294 |
| E | PO4402 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 E 402 |
| Chain | Residue |
| E | HIS235 |
| E | GLY247 |
| E | GLY248 |
| E | HIS250 |
| E | LYS290 |
| E | THR341 |
| E | U5P401 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue U5P F 401 |
| Chain | Residue |
| F | HIS250 |
| F | LYS290 |
| F | VAL292 |
| F | CYS293 |
| F | SER294 |
| F | PO4402 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 F 402 |
| Chain | Residue |
| F | HIS235 |
| F | GLY247 |
| F | GLY248 |
| F | HIS250 |
| F | LYS290 |
| F | THR341 |
| F | U5P401 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 360 |
| Details | Domain: {"description":"Nsp15 N-terminal oligomerization","evidences":[{"source":"PROSITE-ProRule","id":"PRU01305","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 750 |
| Details | Domain: {"description":"AV-Nsp11N/CoV-Nsp15M","evidences":[{"source":"PROSITE-ProRule","id":"PRU01306","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 834 |
| Details | Domain: {"description":"NendoU","evidences":[{"source":"PROSITE-ProRule","id":"PRU01303","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton donor; for uridylate-specific endoribonuclease nsp15 activity","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton acceptor; for uridylate-specific endoribonuclease nsp15 activity","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Active site: {"description":"For uridylate-specific endoribonuclease nsp15 activity","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | Site: {"description":"Uracil recognition site","evidences":[{"source":"PubMed","id":"33504779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33564093","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
