7K0R
Nucleotide bound SARS-CoV-2 Nsp15
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue U5P A 401 |
| Chain | Residue |
| A | HIS250 |
| A | LYS290 |
| A | VAL292 |
| A | CYS293 |
| A | SER294 |
| A | PO4402 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 402 |
| Chain | Residue |
| A | HIS250 |
| A | LYS290 |
| A | THR341 |
| A | U5P401 |
| A | HIS235 |
| A | GLY247 |
| A | GLY248 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue U5P B 401 |
| Chain | Residue |
| B | HIS250 |
| B | LYS290 |
| B | VAL292 |
| B | CYS293 |
| B | SER294 |
| B | PO4402 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 B 402 |
| Chain | Residue |
| B | HIS235 |
| B | GLY247 |
| B | GLY248 |
| B | HIS250 |
| B | LYS290 |
| B | THR341 |
| B | U5P401 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue U5P C 401 |
| Chain | Residue |
| C | HIS250 |
| C | LYS290 |
| C | VAL292 |
| C | CYS293 |
| C | SER294 |
| C | PO4402 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 C 402 |
| Chain | Residue |
| C | HIS235 |
| C | GLY247 |
| C | GLY248 |
| C | HIS250 |
| C | LYS290 |
| C | THR341 |
| C | U5P401 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue U5P D 401 |
| Chain | Residue |
| D | HIS250 |
| D | LYS290 |
| D | VAL292 |
| D | CYS293 |
| D | SER294 |
| D | PO4402 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 D 402 |
| Chain | Residue |
| D | HIS235 |
| D | GLY247 |
| D | GLY248 |
| D | HIS250 |
| D | LYS290 |
| D | THR341 |
| D | U5P401 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue U5P E 401 |
| Chain | Residue |
| E | HIS250 |
| E | LYS290 |
| E | VAL292 |
| E | CYS293 |
| E | SER294 |
| E | PO4402 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 E 402 |
| Chain | Residue |
| E | HIS235 |
| E | GLY247 |
| E | GLY248 |
| E | HIS250 |
| E | LYS290 |
| E | THR341 |
| E | U5P401 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue U5P F 401 |
| Chain | Residue |
| F | HIS250 |
| F | LYS290 |
| F | VAL292 |
| F | CYS293 |
| F | SER294 |
| F | PO4402 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 F 402 |
| Chain | Residue |
| F | HIS235 |
| F | GLY247 |
| F | GLY248 |
| F | HIS250 |
| F | LYS290 |
| F | THR341 |
| F | U5P401 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Proton donor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | HIS235 | |
| B | HIS235 | |
| C | HIS235 | |
| D | HIS235 | |
| E | HIS235 | |
| F | HIS235 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | ACT_SITE: Proton acceptor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | HIS250 | |
| B | HIS250 | |
| C | HIS250 | |
| D | HIS250 | |
| E | HIS250 | |
| F | HIS250 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | ACT_SITE: For uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779 |
| Chain | Residue | Details |
| A | LYS290 | |
| B | LYS290 | |
| C | LYS290 | |
| D | LYS290 | |
| E | LYS290 | |
| F | LYS290 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | LYS290 | |
| B | LYS290 | |
| C | LYS290 | |
| D | LYS290 | |
| E | LYS290 | |
| F | LYS290 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | THR341 | |
| B | THR341 | |
| C | THR341 | |
| D | THR341 | |
| E | THR341 | |
| F | THR341 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | LYS290 | |
| B | LYS290 | |
| C | LYS290 | |
| D | LYS290 | |
| E | LYS290 | |
| F | LYS290 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | SITE: Uracil recognition site => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | SER294 | |
| B | SER294 | |
| C | SER294 | |
| D | SER294 | |
| E | SER294 | |
| F | SER294 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
| Chain | Residue | Details |
| A | GLN347 | |
| B | GLN347 | |
| C | GLN347 | |
| D | GLN347 | |
| E | GLN347 | |
| F | GLN347 |
