Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7K0P

Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004758	molecular_function	serine C-palmitoyltransferase activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006665	biological_process	sphingolipid metabolic process
A	0006686	biological_process	sphingomyelin biosynthetic process
A	0009058	biological_process	biosynthetic process
A	0016020	cellular_component	membrane
A	0016746	molecular_function	acyltransferase activity
A	0017059	cellular_component	serine C-palmitoyltransferase complex
A	0030148	biological_process	sphingolipid biosynthetic process
A	0030170	molecular_function	pyridoxal phosphate binding
A	0035339	cellular_component	SPOTS complex
A	0046511	biological_process	sphinganine biosynthetic process
A	0046512	biological_process	sphingosine biosynthetic process
A	0046513	biological_process	ceramide biosynthetic process
A	1904504	biological_process	positive regulation of lipophagy
A	1904649	biological_process	regulation of fat cell apoptotic process
B	0004758	molecular_function	serine C-palmitoyltransferase activity
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006665	biological_process	sphingolipid metabolic process
B	0006686	biological_process	sphingomyelin biosynthetic process
B	0009058	biological_process	biosynthetic process
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0017059	cellular_component	serine C-palmitoyltransferase complex
B	0030148	biological_process	sphingolipid biosynthetic process
B	0030170	molecular_function	pyridoxal phosphate binding
B	0046511	biological_process	sphinganine biosynthetic process
B	0046512	biological_process	sphingosine biosynthetic process
B	0046513	biological_process	ceramide biosynthetic process
B	0060612	biological_process	adipose tissue development
B	1904504	biological_process	positive regulation of lipophagy
C	0004758	molecular_function	serine C-palmitoyltransferase activity
C	0005515	molecular_function	protein binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006665	biological_process	sphingolipid metabolic process
C	0008104	biological_process	protein localization
C	0016020	cellular_component	membrane
C	0017059	cellular_component	serine C-palmitoyltransferase complex
C	0030148	biological_process	sphingolipid biosynthetic process
C	0046512	biological_process	sphingosine biosynthetic process
C	0046513	biological_process	ceramide biosynthetic process
D	0002903	biological_process	negative regulation of B cell apoptotic process
D	0005515	molecular_function	protein binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005886	cellular_component	plasma membrane
D	0006672	biological_process	ceramide metabolic process
D	0006686	biological_process	sphingomyelin biosynthetic process
D	0006940	biological_process	regulation of smooth muscle contraction
D	0010508	biological_process	positive regulation of autophagy
D	0016020	cellular_component	membrane
D	0030148	biological_process	sphingolipid biosynthetic process
D	0030667	cellular_component	secretory granule membrane
D	0035339	cellular_component	SPOTS complex
D	0035579	cellular_component	specific granule membrane
D	0042552	biological_process	myelination
D	0044255	biological_process	cellular lipid metabolic process
D	0061744	biological_process	motor behavior
D	0090153	biological_process	regulation of sphingolipid biosynthetic process
D	0090156	biological_process	intracellular sphingolipid homeostasis
D	1900060	biological_process	negative regulation of ceramide biosynthetic process
D	1900182	biological_process	positive regulation of protein localization to nucleus
D	2000303	biological_process	regulation of ceramide biosynthetic process
E	0004758	molecular_function	serine C-palmitoyltransferase activity
E	0005515	molecular_function	protein binding
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0006665	biological_process	sphingolipid metabolic process
E	0006686	biological_process	sphingomyelin biosynthetic process
E	0009058	biological_process	biosynthetic process
E	0016020	cellular_component	membrane
E	0016746	molecular_function	acyltransferase activity
E	0017059	cellular_component	serine C-palmitoyltransferase complex
E	0030148	biological_process	sphingolipid biosynthetic process
E	0030170	molecular_function	pyridoxal phosphate binding
E	0035339	cellular_component	SPOTS complex
E	0046511	biological_process	sphinganine biosynthetic process
E	0046512	biological_process	sphingosine biosynthetic process
E	0046513	biological_process	ceramide biosynthetic process
E	1904504	biological_process	positive regulation of lipophagy
E	1904649	biological_process	regulation of fat cell apoptotic process
F	0004758	molecular_function	serine C-palmitoyltransferase activity
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0006665	biological_process	sphingolipid metabolic process
F	0006686	biological_process	sphingomyelin biosynthetic process
F	0009058	biological_process	biosynthetic process
F	0016020	cellular_component	membrane
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0017059	cellular_component	serine C-palmitoyltransferase complex
F	0030148	biological_process	sphingolipid biosynthetic process
F	0030170	molecular_function	pyridoxal phosphate binding
F	0046511	biological_process	sphinganine biosynthetic process
F	0046512	biological_process	sphingosine biosynthetic process
F	0046513	biological_process	ceramide biosynthetic process
F	0060612	biological_process	adipose tissue development
F	1904504	biological_process	positive regulation of lipophagy
G	0004758	molecular_function	serine C-palmitoyltransferase activity
G	0005515	molecular_function	protein binding
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0006665	biological_process	sphingolipid metabolic process
G	0008104	biological_process	protein localization
G	0016020	cellular_component	membrane
G	0017059	cellular_component	serine C-palmitoyltransferase complex
G	0030148	biological_process	sphingolipid biosynthetic process
G	0046512	biological_process	sphingosine biosynthetic process
G	0046513	biological_process	ceramide biosynthetic process
H	0002903	biological_process	negative regulation of B cell apoptotic process
H	0005515	molecular_function	protein binding
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005886	cellular_component	plasma membrane
H	0006672	biological_process	ceramide metabolic process
H	0006686	biological_process	sphingomyelin biosynthetic process
H	0006940	biological_process	regulation of smooth muscle contraction
H	0010508	biological_process	positive regulation of autophagy
H	0016020	cellular_component	membrane
H	0030148	biological_process	sphingolipid biosynthetic process
H	0030667	cellular_component	secretory granule membrane
H	0035339	cellular_component	SPOTS complex
H	0035579	cellular_component	specific granule membrane
H	0042552	biological_process	myelination
H	0044255	biological_process	cellular lipid metabolic process
H	0061744	biological_process	motor behavior
H	0090153	biological_process	regulation of sphingolipid biosynthetic process
H	0090156	biological_process	intracellular sphingolipid homeostasis
H	1900060	biological_process	negative regulation of ceramide biosynthetic process
H	1900182	biological_process	positive regulation of protein localization to nucleus
H	2000303	biological_process	regulation of ceramide biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00599
Number of Residues	10
Details	AA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site. TFTKSFGASG

Chain	Residue	Details
B	THR376-GLY385

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	138
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
D	MET1-GLY21
D	LEU64-LYS100
D	PRO140-TYR153
H	MET1-GLY21
H	LEU64-LYS100
H	PRO140-TYR153

site_id	SWS_FT_FI2
Number of Residues	146
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:33558762, ECO:0007744\|PDB:6M4N, ECO:0007744\|PDB:6M4O, ECO:0007744\|PDB:7CQI, ECO:0007744\|PDB:7CQK

Chain	Residue	Details
D	ILE22-SER44
D	VAL45-PHE63
D	PHE101-THR117
D	ILE122-LEU139
H	ILE22-SER44
H	VAL45-PHE63
H	PHE101-THR117
H	ILE122-LEU139

site_id	SWS_FT_FI3
Number of Residues	6
Details	TOPO_DOM: Lumenal => ECO:0000255

Chain	Residue	Details
D	LYS118-GLN121
H	LYS118-GLN121

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Hydroxyproline => ECO:0000269\|PubMed:36408842

Chain	Residue	Details
D	PRO137
H	PRO137

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)