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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7JUP

Structure of human TRPA1 in complex with antagonist compound 21

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue VKM A 1101

Chain	Residue
A	LEU707
A	ARG975
A	MET978
A	GLN979
A	LEU982
A	HIS983
A	LEU708
A	TRP711
A	GLN851
A	ARG852
A	GLU854
A	ILE858
A	ALA971
A	LYS974

site_id	AC2
Number of Residues	12
Details	binding site for residue VKM B 1101

Chain	Residue
B	LEU707
B	LEU708
B	TRP711
B	GLN851
B	ARG852
B	GLU854
B	ILE858
B	ALA971
B	LYS974
B	ARG975
B	GLN979
B	HIS983

site_id	AC3
Number of Residues	12
Details	binding site for residue VKM C 1101

Chain	Residue
C	LEU707
C	LEU708
C	TRP711
C	GLN851
C	GLU854
C	ILE858
C	VAL967
C	ALA971
C	LYS974
C	MET978
C	GLN979
C	HIS983

site_id	AC4
Number of Residues	12
Details	binding site for residue VKM D 1101

Chain	Residue
D	LEU708
D	TRP711
D	GLN851
D	GLU854
D	ILE858
D	ALA971
D	LYS974
D	ARG975
D	MET978
D	GLN979
D	LEU982
D	HIS983

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DISDTRLLNegDL

Chain	Residue	Details
A	ASP468-LEU480

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:31866091, ECO:0007744\|PDB:6PQO

Chain	Residue	Details
A	HIS719-ASN739
B	HIS719-ASN739
C	HIS719-ASN739
D	HIS719-ASN739

site_id	SWS_FT_FI2
Number of Residues	200
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	ILE740-SER767
C	VAL824-HIS829
C	ASN893-PRO901
C	LEU923-HIS933
D	ILE740-SER767
D	VAL824-HIS829
D	ASN893-PRO901
D	LEU923-HIS933
A	VAL824-HIS829
A	ASN893-PRO901
A	LEU923-HIS933
B	ILE740-SER767
B	VAL824-HIS829
B	ASN893-PRO901
B	LEU923-HIS933
C	ILE740-SER767

site_id	SWS_FT_FI3
Number of Residues	100
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:31866091, ECO:0007744\|PDB:6PQO

Chain	Residue	Details
A	TYR768-PHE793
B	TYR768-PHE793
C	TYR768-PHE793
D	TYR768-PHE793

site_id	SWS_FT_FI4
Number of Residues	60
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	GLN794-ASN798
A	GLN851-MET862
B	GLN794-ASN798
B	GLN851-MET862
C	GLN794-ASN798
C	GLN851-MET862
D	GLN794-ASN798
D	GLN851-MET862

site_id	SWS_FT_FI5
Number of Residues	96
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:31866091, ECO:0007744\|PDB:6PQO

Chain	Residue	Details
A	TYR799-PHE823
B	TYR799-PHE823
C	TYR799-PHE823
D	TYR799-PHE823

site_id	SWS_FT_FI6
Number of Residues	80
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:31866091, ECO:0007744\|PDB:6PQO

Chain	Residue	Details
A	LEU830-LEU850
B	LEU830-LEU850
C	LEU830-LEU850
D	LEU830-LEU850

site_id	SWS_FT_FI7
Number of Residues	116
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:31866091, ECO:0007744\|PDB:6PQO

Chain	Residue	Details
A	LEU863-LEU892
B	LEU863-LEU892
C	LEU863-LEU892
D	LEU863-LEU892

site_id	SWS_FT_FI8
Number of Residues	80
Details	INTRAMEM: Pore-forming => ECO:0000269\|PubMed:31866091, ECO:0007744\|PDB:6PQO

Chain	Residue	Details
A	LEU902-PHE922
B	LEU902-PHE922
C	LEU902-PHE922
D	LEU902-PHE922

site_id	SWS_FT_FI9
Number of Residues	104
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:31866091, ECO:0007744\|PDB:6PQO

Chain	Residue	Details
A	PRO934-ALA960
B	PRO934-ALA960
C	PRO934-ALA960
D	PRO934-ALA960

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: covalent; Cys highly reactive => ECO:0000250\|UniProtKB:Q8BLA8, ECO:0000305\|PubMed:17164327, ECO:0000305\|PubMed:27241698

Chain	Residue	Details
A	CYS621
B	CYS621
C	CYS621
D	CYS621

site_id	SWS_FT_FI11
Number of Residues	8
Details	BINDING: covalent => ECO:0000305\|PubMed:17164327

Chain	Residue	Details
A	CYS641
A	LYS710
B	CYS641
B	LYS710
C	CYS641
C	LYS710
D	CYS641
D	LYS710

site_id	SWS_FT_FI12
Number of Residues	4
Details	BINDING: covalent => ECO:0000305\|PubMed:17164327, ECO:0000305\|PubMed:27241698

Chain	Residue	Details
A	CYS665
B	CYS665
C	CYS665
D	CYS665

site_id	SWS_FT_FI13
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:32641835, ECO:0007744\|PDB:6V9V

Chain	Residue	Details
A	GLU788
C	GLN791
C	ASN805
C	GLU808
D	GLU788
D	GLN791
D	ASN805
D	GLU808
A	GLN791
A	ASN805
A	GLU808
B	GLU788
B	GLN791
B	ASN805
B	GLU808
C	GLU788

site_id	SWS_FT_FI14
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305\|PubMed:25855297

Chain	Residue	Details
A	LYS1046
B	LYS1046
C	LYS1046
D	LYS1046

site_id	SWS_FT_FI15
Number of Residues	4
Details	SITE: Required for C-621 reactivity => ECO:0000269\|PubMed:27241698

Chain	Residue	Details
A	LYS620
B	LYS620
C	LYS620
D	LYS620

site_id	SWS_FT_FI16
Number of Residues	4
Details	SITE: Essential for electrophile activation. Sensor for electrophilic agents => ECO:0000269\|PubMed:31866091, ECO:0000269\|PubMed:32641835

Chain	Residue	Details
A	CYS621
B	CYS621
C	CYS621
D	CYS621

site_id	SWS_FT_FI17
Number of Residues	4
Details	SITE: Key residue for activation by the scorpion wasabi receptor toxin => ECO:0000269\|PubMed:31447178

Chain	Residue	Details
A	PRO622
B	PRO622
C	PRO622
D	PRO622

site_id	SWS_FT_FI18
Number of Residues	8
Details	SITE: Important residue for activation by the scorpion wasabi receptor toxin => ECO:0000269\|PubMed:31447178

Chain	Residue	Details
A	MET634
A	THR646
B	MET634
B	THR646
C	MET634
C	THR646
D	MET634
D	THR646

site_id	SWS_FT_FI19
Number of Residues	4
Details	SITE: Important for electrophile activation => ECO:0000269\|PubMed:31866091, ECO:0000269\|PubMed:32641835

Chain	Residue	Details
A	CYS665
B	CYS665
C	CYS665
D	CYS665

site_id	SWS_FT_FI20
Number of Residues	4
Details	SITE: Crucial for calcium permeation => ECO:0000250\|UniProtKB:Q6RI86

Chain	Residue	Details
A	ASP915
B	ASP915
C	ASP915
D	ASP915

site_id	SWS_FT_FI21
Number of Residues	8
Details	MOD_RES: Cysteine sulfenic acid (-SOH); transient; in hyperoxia => ECO:0000305\|PubMed:21873995

Chain	Residue	Details
A	CYS633
A	CYS856
B	CYS633
B	CYS856
C	CYS633
C	CYS856
D	CYS633
D	CYS856

site_id	SWS_FT_FI22
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN747
A	ASN753
B	ASN747
B	ASN753
C	ASN747
C	ASN753
D	ASN747
D	ASN753

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PDB entries from 2024-08-07

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