Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7JUP

Structure of human TRPA1 in complex with antagonist compound 21

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue VKM A 1101

Chain	Residue
A	LEU707
A	ARG975
A	MET978
A	GLN979
A	LEU982
A	HIS983
A	LEU708
A	TRP711
A	GLN851
A	ARG852
A	GLU854
A	ILE858
A	ALA971
A	LYS974

site_id	AC2
Number of Residues	12
Details	binding site for residue VKM B 1101

Chain	Residue
B	LEU707
B	LEU708
B	TRP711
B	GLN851
B	ARG852
B	GLU854
B	ILE858
B	ALA971
B	LYS974
B	ARG975
B	GLN979
B	HIS983

site_id	AC3
Number of Residues	12
Details	binding site for residue VKM C 1101

Chain	Residue
C	LEU707
C	LEU708
C	TRP711
C	GLN851
C	GLU854
C	ILE858
C	VAL967
C	ALA971
C	LYS974
C	MET978
C	GLN979
C	HIS983

site_id	AC4
Number of Residues	12
Details	binding site for residue VKM D 1101

Chain	Residue
D	LEU708
D	TRP711
D	GLN851
D	GLU854
D	ILE858
D	ALA971
D	LYS974
D	ARG975
D	MET978
D	GLN979
D	LEU982
D	HIS983

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DISDTRLLNegDL

Chain	Residue	Details
A	ASP468-LEU480

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	92
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	44
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	116
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	80
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	104
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PQO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	116
Details	Repeat: {"description":"ANK 13","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	116
Details	Repeat: {"description":"ANK 14","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	116
Details	Repeat: {"description":"ANK 15","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	120
Details	Repeat: {"description":"ANK 16","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	116
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	4
Details	Binding site: {"description":"covalent; Cys highly reactive","evidences":[{"source":"UniProtKB","id":"Q8BLA8","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"17164327","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27241698","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	8
Details	Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"17164327","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"17164327","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27241698","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32641835","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V9V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25855297","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	4
Details	Site: {"description":"Required for C-621 reactivity","evidences":[{"source":"PubMed","id":"27241698","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	4
Details	Site: {"description":"Essential for electrophile activation. Sensor for electrophilic agents","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32641835","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	4
Details	Site: {"description":"Key residue for activation by the scorpion wasabi receptor toxin","evidences":[{"source":"PubMed","id":"31447178","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	8
Details	Site: {"description":"Important residue for activation by the scorpion wasabi receptor toxin","evidences":[{"source":"PubMed","id":"31447178","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	4
Details	Site: {"description":"Important for electrophile activation","evidences":[{"source":"PubMed","id":"31866091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32641835","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	4
Details	Site: {"description":"Crucial for calcium permeation","evidences":[{"source":"UniProtKB","id":"Q6RI86","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	8
Details	Modified residue: {"description":"Cysteine sulfenic acid (-SOH); transient; in hyperoxia","evidences":[{"source":"PubMed","id":"21873995","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)