7JUO

CBP bromodomain complexed with YF2-23

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription
B	0004402	molecular_function	histone acetyltransferase activity
B	0006355	biological_process	regulation of DNA-templated transcription
C	0004402	molecular_function	histone acetyltransferase activity
C	0006355	biological_process	regulation of DNA-templated transcription
D	0004402	molecular_function	histone acetyltransferase activity
D	0006355	biological_process	regulation of DNA-templated transcription
E	0004402	molecular_function	histone acetyltransferase activity
E	0006355	biological_process	regulation of DNA-templated transcription
F	0004402	molecular_function	histone acetyltransferase activity
F	0006355	biological_process	regulation of DNA-templated transcription
G	0004402	molecular_function	histone acetyltransferase activity
G	0006355	biological_process	regulation of DNA-templated transcription
H	0004402	molecular_function	histone acetyltransferase activity
H	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue YF2 A 1201

Chain	Residue
A	PRO1110
B	LEU1119
B	LEU1120
B	YF21201
A	PRO1114
A	VAL1115
A	ASP1116
A	LEU1119
A	LEU1120
A	ASN1168
A	VAL1174
A	HOH1311

---

site_id	AC2
Number of Residues	15
Details	binding site for residue YF2 D 1201

Chain	Residue
C	LEU1119
C	LEU1120
C	YF21201
D	PRO1110
D	GLN1113
D	PRO1114
D	VAL1115
D	ASP1116
D	LEU1119
D	LEU1120
D	ASN1168
D	ARG1173
D	VAL1174
D	PHE1177
D	HOH1310

---

site_id	AC3
Number of Residues	14
Details	binding site for residue YF2 C 1201

Chain	Residue
C	PRO1110
C	PHE1111
C	GLN1113
C	PRO1114
C	VAL1115
C	ASP1116
C	LEU1119
C	LEU1120
C	ASN1168
C	ARG1173
C	VAL1174
C	HOH1302
D	LEU1119
D	YF21201

---

site_id	AC4
Number of Residues	14
Details	binding site for residue YF2 B 1201

Chain	Residue
A	LEU1119
A	LEU1120
A	YF21201
B	PRO1110
B	GLN1113
B	PRO1114
B	VAL1115
B	ASP1116
B	LEU1119
B	LEU1120
B	ASN1168
B	ARG1173
B	VAL1174
B	HOH1305

---

site_id	AC5
Number of Residues	13
Details	binding site for residue YF2 F 1201

Chain	Residue
E	LEU1119
E	LEU1120
E	YF21201
F	PRO1110
F	GLN1113
F	PRO1114
F	VAL1115
F	ASP1116
F	LEU1120
F	ASN1168
F	ARG1173
F	VAL1174
F	PHE1177

---

site_id	AC6
Number of Residues	13
Details	binding site for residue YF2 G 1201

Chain	Residue
G	PRO1110
G	GLN1113
G	PRO1114
G	VAL1115
G	ASP1116
G	LEU1119
G	LEU1120
G	ASN1168
G	ARG1173
G	VAL1174
G	HOH1306
H	LEU1119
H	YF21201

---

site_id	AC7
Number of Residues	12
Details	binding site for residue YF2 H 1201

Chain	Residue
G	LEU1119
G	LEU1120
G	YF21201
H	PRO1110
H	GLN1113
H	PRO1114
H	VAL1115
H	ASP1116
H	LEU1120
H	ASN1168
H	VAL1174
H	HOH1303

---

site_id	AC8
Number of Residues	14
Details	binding site for residue YF2 E 1201

Chain	Residue
E	LEU1119
E	LEU1120
E	ILE1122
E	ASN1168
E	ARG1173
E	VAL1174
F	LEU1119
F	YF21201
E	PRO1110
E	PHE1111
E	GLN1113
E	PRO1114
E	VAL1115
E	ASP1116

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY

Chain	Residue	Details
A	SER1108-TYR1167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	856
Details	Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	368
Details	Region: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"24361270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	144
Details	Region: {"description":"Interaction with ASF1A","evidences":[{"source":"PubMed","id":"24616510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---