7JTW

Crystal structure of RORgt with compound (4R)-6-[(2,5-dichloro-3-{[(2R,4R)-1-(cyclopentanecarbonyl)-2-methylpiperidin-4-yl]oxy}phenyl)amino]-6-oxo-4-phenylhexanoic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue VK4 A 601

Chain	Residue
A	TRP317
A	GLU379
A	PHE388
A	LEU391
A	ILE397
A	SER404
A	HIS479
A	GOL602
A	CYS320
A	HIS323
A	LEU324
A	MET365
A	ALA368
A	VAL376
A	PHE377
A	PHE378

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site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 602

Chain	Residue
A	GLN286
A	ARG364
A	MET365
A	ARG367
A	VK4601
A	HOH715

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site_id	AC3
Number of Residues	9
Details	binding site for residue GOL A 603

Chain	Residue
A	CYS366
A	ARG367
A	LEU407
A	SER408
A	HIS411
A	PHE412
A	HOH709
A	HOH711
A	HOH757

---

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL A 604

Chain	Residue
A	MET313
A	TRP314
A	HIS490
A	HOH705

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site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 A 605

Chain	Residue
A	ARG296
A	TYR369
A	ALA371
A	ASP372
A	HOH704
A	HOH711

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