Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7JSJ

Structure of the NaCT-PF2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005343	molecular_function	organic acid:sodium symporter activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0015137	molecular_function	citrate transmembrane transporter activity
A	0015141	molecular_function	succinate transmembrane transporter activity
A	0015142	molecular_function	tricarboxylic acid transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015370	molecular_function	solute:sodium symporter activity
A	0015711	biological_process	organic anion transport
A	0015729	biological_process	oxaloacetate transport
A	0015741	biological_process	fumarate transport
A	0015742	biological_process	alpha-ketoglutarate transport
A	0015744	biological_process	succinate transport
A	0015746	biological_process	citrate transport
A	0016020	cellular_component	membrane
A	0017153	molecular_function	sodium:dicarboxylate symporter activity
A	0022857	molecular_function	transmembrane transporter activity
A	0035674	biological_process	tricarboxylic acid transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0071285	biological_process	cellular response to lithium ion
A	0071422	biological_process	succinate transmembrane transport
B	0005343	molecular_function	organic acid:sodium symporter activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0015137	molecular_function	citrate transmembrane transporter activity
B	0015141	molecular_function	succinate transmembrane transporter activity
B	0015142	molecular_function	tricarboxylic acid transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015370	molecular_function	solute:sodium symporter activity
B	0015711	biological_process	organic anion transport
B	0015729	biological_process	oxaloacetate transport
B	0015741	biological_process	fumarate transport
B	0015742	biological_process	alpha-ketoglutarate transport
B	0015744	biological_process	succinate transport
B	0015746	biological_process	citrate transport
B	0016020	cellular_component	membrane
B	0017153	molecular_function	sodium:dicarboxylate symporter activity
B	0022857	molecular_function	transmembrane transporter activity
B	0035674	biological_process	tricarboxylic acid transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0071285	biological_process	cellular response to lithium ion
B	0071422	biological_process	succinate transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS01271
Number of Residues	17
Details	NA_SULFATE Sodium:sulfate symporter family signature. ASfaFmlPVAtppNaIV

Chain	Residue	Details
A	ALA498-VAL514

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	64
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	30
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	22
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	84
Details	Transmembrane: {"description":"Discontinuously helical; Name=4","evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	136
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	74
Details	Transmembrane: {"description":"Discontinuously helical; Name=5","evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	52
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	34
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	72
Details	Transmembrane: {"description":"Discontinuously helical; Name=9","evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	60
Details	Transmembrane: {"description":"Discontinuously helical; Name=10","evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Motif: {"description":"SNT motif","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	4
Details	Motif: {"description":"TXP motif","evidences":[{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33597751","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39622972","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7JSJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UVB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)