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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7JPK

Rabbit Cav1.1 in the presence of 100 micromolar (S)-(-)-Bay K8644 in nanodiscs at 3.0 Angstrom resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005245molecular_functionvoltage-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005886cellular_componentplasma membrane
A0005891cellular_componentvoltage-gated calcium channel complex
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006936biological_processmuscle contraction
A0008331molecular_functionhigh voltage-gated calcium channel activity
A0016020cellular_componentmembrane
A0030315cellular_componentT-tubule
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0044325molecular_functiontransmembrane transporter binding
A0045933biological_processpositive regulation of muscle contraction
A0046872molecular_functionmetal ion binding
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051279biological_processregulation of release of sequestered calcium ion into cytosol
A0055085biological_processtransmembrane transport
A0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
A0070588biological_processcalcium ion transmembrane transport
A0071313biological_processcellular response to caffeine
A0098703biological_processcalcium ion import across plasma membrane
A1990454cellular_componentL-type voltage-gated calcium channel complex
E0005245molecular_functionvoltage-gated calcium channel activity
E0005246molecular_functioncalcium channel regulator activity
E0005262molecular_functioncalcium channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0005891cellular_componentvoltage-gated calcium channel complex
E0006811biological_processmonoatomic ion transport
E0006816biological_processcalcium ion transport
E0016020cellular_componentmembrane
E0030315cellular_componentT-tubule
E0034220biological_processmonoatomic ion transmembrane transport
E0034702cellular_componentmonoatomic ion channel complex
E0042383cellular_componentsarcolemma
E0045933biological_processpositive regulation of muscle contraction
E0070588biological_processcalcium ion transmembrane transport
E1902514biological_processregulation of calcium ion transmembrane transport via high voltage-gated calcium channel
E1990454cellular_componentL-type voltage-gated calcium channel complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues249
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues96
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat I","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues80
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"26680202","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat II","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat III","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat III","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S4 of repeat IV","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues66
DetailsRegion: {"description":"Dihydropyridine binding","evidences":[{"source":"PubMed","id":"1656465","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues42
DetailsRegion: {"description":"Phenylalkylamine binding","evidences":[{"source":"PubMed","id":"2174553","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues3
DetailsMotif: {"description":"Selectivity filter of repeat I","evidences":[{"source":"PubMed","id":"26680202","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues3
DetailsMotif: {"description":"Selectivity filter of repeat II","evidences":[{"source":"PubMed","id":"26680202","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues3
DetailsMotif: {"description":"Selectivity filter of repeat III","evidences":[{"source":"PubMed","id":"26680202","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues3
DetailsMotif: {"description":"Selectivity filter of repeat IV","evidences":[{"source":"PubMed","id":"26680202","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GJV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues10
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI35
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PDB","id":"5GJV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI36
Number of Residues13
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"26680202","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI37
Number of Residues82
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"26680202","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27580036","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI38
Number of Residues177
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI39
Number of Residues91
DetailsDomain: {"description":"Cache"}
ChainResidueDetails
site_idSWS_FT_FI40
Number of Residues4
DetailsMotif: {"description":"MIDAS-like motif"}
ChainResidueDetails
site_idSWS_FT_FI41
Number of Residues3
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI42
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P54290","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-08-27

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