7JOS

Crystal structure of BbKI complexed with Human Kallikrein 4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0022617	biological_process	extracellular matrix disassembly
A	0030141	cellular_component	secretory granule
A	0031214	biological_process	biomineral tissue development
A	0046872	molecular_function	metal ion binding
A	0051604	biological_process	protein maturation
A	0097186	biological_process	amelogenesis
B	0004866	molecular_function	endopeptidase inhibitor activity
B	0004867	molecular_function	serine-type endopeptidase inhibitor activity
B	0005576	cellular_component	extracellular region
B	0030414	molecular_function	peptidase inhibitor activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0016787	molecular_function	hydrolase activity
C	0022617	biological_process	extracellular matrix disassembly
C	0030141	cellular_component	secretory granule
C	0031214	biological_process	biomineral tissue development
C	0046872	molecular_function	metal ion binding
C	0051604	biological_process	protein maturation
C	0097186	biological_process	amelogenesis
D	0004866	molecular_function	endopeptidase inhibitor activity
D	0004867	molecular_function	serine-type endopeptidase inhibitor activity
D	0005576	cellular_component	extracellular region
D	0030414	molecular_function	peptidase inhibitor activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006508	biological_process	proteolysis
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0016787	molecular_function	hydrolase activity
E	0022617	biological_process	extracellular matrix disassembly
E	0030141	cellular_component	secretory granule
E	0031214	biological_process	biomineral tissue development
E	0046872	molecular_function	metal ion binding
E	0051604	biological_process	protein maturation
E	0097186	biological_process	amelogenesis
F	0004866	molecular_function	endopeptidase inhibitor activity
F	0004867	molecular_function	serine-type endopeptidase inhibitor activity
F	0005576	cellular_component	extracellular region
F	0030414	molecular_function	peptidase inhibitor activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0006508	biological_process	proteolysis
G	0008233	molecular_function	peptidase activity
G	0008236	molecular_function	serine-type peptidase activity
G	0016787	molecular_function	hydrolase activity
G	0022617	biological_process	extracellular matrix disassembly
G	0030141	cellular_component	secretory granule
G	0031214	biological_process	biomineral tissue development
G	0046872	molecular_function	metal ion binding
G	0051604	biological_process	protein maturation
G	0097186	biological_process	amelogenesis
H	0004866	molecular_function	endopeptidase inhibitor activity
H	0004867	molecular_function	serine-type endopeptidase inhibitor activity
H	0005576	cellular_component	extracellular region
H	0030414	molecular_function	peptidase inhibitor activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0006508	biological_process	proteolysis
I	0008233	molecular_function	peptidase activity
I	0008236	molecular_function	serine-type peptidase activity
I	0016787	molecular_function	hydrolase activity
I	0022617	biological_process	extracellular matrix disassembly
I	0030141	cellular_component	secretory granule
I	0031214	biological_process	biomineral tissue development
I	0046872	molecular_function	metal ion binding
I	0051604	biological_process	protein maturation
I	0097186	biological_process	amelogenesis
J	0004866	molecular_function	endopeptidase inhibitor activity
J	0004867	molecular_function	serine-type endopeptidase inhibitor activity
J	0005576	cellular_component	extracellular region
J	0030414	molecular_function	peptidase inhibitor activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0006508	biological_process	proteolysis
K	0008233	molecular_function	peptidase activity
K	0008236	molecular_function	serine-type peptidase activity
K	0016787	molecular_function	hydrolase activity
K	0022617	biological_process	extracellular matrix disassembly
K	0030141	cellular_component	secretory granule
K	0031214	biological_process	biomineral tissue development
K	0046872	molecular_function	metal ion binding
K	0051604	biological_process	protein maturation
K	0097186	biological_process	amelogenesis
L	0004866	molecular_function	endopeptidase inhibitor activity
L	0004867	molecular_function	serine-type endopeptidase inhibitor activity
L	0005576	cellular_component	extracellular region
L	0030414	molecular_function	peptidase inhibitor activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0006508	biological_process	proteolysis
M	0008233	molecular_function	peptidase activity
M	0008236	molecular_function	serine-type peptidase activity
M	0016787	molecular_function	hydrolase activity
M	0022617	biological_process	extracellular matrix disassembly
M	0030141	cellular_component	secretory granule
M	0031214	biological_process	biomineral tissue development
M	0046872	molecular_function	metal ion binding
M	0051604	biological_process	protein maturation
M	0097186	biological_process	amelogenesis
N	0004866	molecular_function	endopeptidase inhibitor activity
N	0004867	molecular_function	serine-type endopeptidase inhibitor activity
N	0005576	cellular_component	extracellular region
N	0030414	molecular_function	peptidase inhibitor activity

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC

Chain	Residue	Details
A	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScnGDSGGPLI

Chain	Residue	Details
A	ASP189-ILE200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1547
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	21
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"16950394","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16950394","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---