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7JOS

Crystal structure of BbKI complexed with Human Kallikrein 4

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0006508biological_processproteolysis
A0008236molecular_functionserine-type peptidase activity
A0022617biological_processextracellular matrix disassembly
A0030141cellular_componentsecretory granule
A0031214biological_processbiomineral tissue development
A0046872molecular_functionmetal ion binding
A0097186biological_processamelogenesis
B0004866molecular_functionendopeptidase inhibitor activity
B0004867molecular_functionserine-type endopeptidase inhibitor activity
B0005576cellular_componentextracellular region
C0004252molecular_functionserine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0006508biological_processproteolysis
C0008236molecular_functionserine-type peptidase activity
C0022617biological_processextracellular matrix disassembly
C0030141cellular_componentsecretory granule
C0031214biological_processbiomineral tissue development
C0046872molecular_functionmetal ion binding
C0097186biological_processamelogenesis
D0004866molecular_functionendopeptidase inhibitor activity
D0004867molecular_functionserine-type endopeptidase inhibitor activity
D0005576cellular_componentextracellular region
E0004252molecular_functionserine-type endopeptidase activity
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0006508biological_processproteolysis
E0008236molecular_functionserine-type peptidase activity
E0022617biological_processextracellular matrix disassembly
E0030141cellular_componentsecretory granule
E0031214biological_processbiomineral tissue development
E0046872molecular_functionmetal ion binding
E0097186biological_processamelogenesis
F0004866molecular_functionendopeptidase inhibitor activity
F0004867molecular_functionserine-type endopeptidase inhibitor activity
F0005576cellular_componentextracellular region
G0004252molecular_functionserine-type endopeptidase activity
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0006508biological_processproteolysis
G0008236molecular_functionserine-type peptidase activity
G0022617biological_processextracellular matrix disassembly
G0030141cellular_componentsecretory granule
G0031214biological_processbiomineral tissue development
G0046872molecular_functionmetal ion binding
G0097186biological_processamelogenesis
H0004866molecular_functionendopeptidase inhibitor activity
H0004867molecular_functionserine-type endopeptidase inhibitor activity
H0005576cellular_componentextracellular region
I0004252molecular_functionserine-type endopeptidase activity
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0006508biological_processproteolysis
I0008236molecular_functionserine-type peptidase activity
I0022617biological_processextracellular matrix disassembly
I0030141cellular_componentsecretory granule
I0031214biological_processbiomineral tissue development
I0046872molecular_functionmetal ion binding
I0097186biological_processamelogenesis
J0004866molecular_functionendopeptidase inhibitor activity
J0004867molecular_functionserine-type endopeptidase inhibitor activity
J0005576cellular_componentextracellular region
K0004252molecular_functionserine-type endopeptidase activity
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0006508biological_processproteolysis
K0008236molecular_functionserine-type peptidase activity
K0022617biological_processextracellular matrix disassembly
K0030141cellular_componentsecretory granule
K0031214biological_processbiomineral tissue development
K0046872molecular_functionmetal ion binding
K0097186biological_processamelogenesis
L0004866molecular_functionendopeptidase inhibitor activity
L0004867molecular_functionserine-type endopeptidase inhibitor activity
L0005576cellular_componentextracellular region
M0004252molecular_functionserine-type endopeptidase activity
M0005515molecular_functionprotein binding
M0005576cellular_componentextracellular region
M0006508biological_processproteolysis
M0008236molecular_functionserine-type peptidase activity
M0022617biological_processextracellular matrix disassembly
M0030141cellular_componentsecretory granule
M0031214biological_processbiomineral tissue development
M0046872molecular_functionmetal ion binding
M0097186biological_processamelogenesis
N0004866molecular_functionendopeptidase inhibitor activity
N0004867molecular_functionserine-type endopeptidase inhibitor activity
N0005576cellular_componentextracellular region
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC
ChainResidueDetails
ALEU53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScnGDSGGPLI
ChainResidueDetails
AASP189-ILE200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues21
DetailsACT_SITE: Charge relay system => ECO:0000269|PubMed:16950394
ChainResidueDetails
AHIS57
AASP102
ASER195
CHIS57
CASP102
CSER195
EHIS57
EASP102
ESER195
GHIS57
GASP102
GSER195
IHIS57
IASP102
ISER195
KHIS57
KASP102
KSER195
MHIS57
MASP102
MSER195

site_idSWS_FT_FI2
Number of Residues14
DetailsBINDING: BINDING => ECO:0000269|PubMed:16950394
ChainResidueDetails
AHIS25
AGLU77
CHIS25
CGLU77
EHIS25
EGLU77
GHIS25
GGLU77
IHIS25
IGLU77
KHIS25
KGLU77
MHIS25
MGLU77

site_idSWS_FT_FI3
Number of Residues7
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN159
CASN159
EASN159
GASN159
IASN159
KASN159
MASN159

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PDB entries from 2024-06-12

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