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7JN1

Sheep Connexin-46 at 2.5 angstroms resolution, Lipid Class 3

Functional Information from GO Data
ChainGOidnamespacecontents
A0005243molecular_functiongap junction channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0005921cellular_componentgap junction
A0005922cellular_componentconnexin complex
A0007154biological_processcell communication
A0007267biological_processcell-cell signaling
A0007601biological_processvisual perception
A0055077molecular_functiongap junction hemi-channel activity
A0055085biological_processtransmembrane transport
A1990349biological_processgap junction-mediated intercellular transport
B0005243molecular_functiongap junction channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005921cellular_componentgap junction
B0005922cellular_componentconnexin complex
B0007154biological_processcell communication
B0007267biological_processcell-cell signaling
B0007601biological_processvisual perception
B0055077molecular_functiongap junction hemi-channel activity
B0055085biological_processtransmembrane transport
B1990349biological_processgap junction-mediated intercellular transport
C0005243molecular_functiongap junction channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0005921cellular_componentgap junction
C0005922cellular_componentconnexin complex
C0007154biological_processcell communication
C0007267biological_processcell-cell signaling
C0007601biological_processvisual perception
C0055077molecular_functiongap junction hemi-channel activity
C0055085biological_processtransmembrane transport
C1990349biological_processgap junction-mediated intercellular transport
D0005243molecular_functiongap junction channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0005921cellular_componentgap junction
D0005922cellular_componentconnexin complex
D0007154biological_processcell communication
D0007267biological_processcell-cell signaling
D0007601biological_processvisual perception
D0055077molecular_functiongap junction hemi-channel activity
D0055085biological_processtransmembrane transport
D1990349biological_processgap junction-mediated intercellular transport
E0005243molecular_functiongap junction channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0005921cellular_componentgap junction
E0005922cellular_componentconnexin complex
E0007154biological_processcell communication
E0007267biological_processcell-cell signaling
E0007601biological_processvisual perception
E0055077molecular_functiongap junction hemi-channel activity
E0055085biological_processtransmembrane transport
E1990349biological_processgap junction-mediated intercellular transport
F0005243molecular_functiongap junction channel activity
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0005921cellular_componentgap junction
F0005922cellular_componentconnexin complex
F0007154biological_processcell communication
F0007267biological_processcell-cell signaling
F0007601biological_processvisual perception
F0055077molecular_functiongap junction hemi-channel activity
F0055085biological_processtransmembrane transport
F1990349biological_processgap junction-mediated intercellular transport
G0005243molecular_functiongap junction channel activity
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0005921cellular_componentgap junction
G0005922cellular_componentconnexin complex
G0007154biological_processcell communication
G0007267biological_processcell-cell signaling
G0007601biological_processvisual perception
G0055077molecular_functiongap junction hemi-channel activity
G0055085biological_processtransmembrane transport
G1990349biological_processgap junction-mediated intercellular transport
H0005243molecular_functiongap junction channel activity
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0005921cellular_componentgap junction
H0005922cellular_componentconnexin complex
H0007154biological_processcell communication
H0007267biological_processcell-cell signaling
H0007601biological_processvisual perception
H0055077molecular_functiongap junction hemi-channel activity
H0055085biological_processtransmembrane transport
H1990349biological_processgap junction-mediated intercellular transport
I0005243molecular_functiongap junction channel activity
I0005515molecular_functionprotein binding
I0005886cellular_componentplasma membrane
I0005921cellular_componentgap junction
I0005922cellular_componentconnexin complex
I0007154biological_processcell communication
I0007267biological_processcell-cell signaling
I0007601biological_processvisual perception
I0055077molecular_functiongap junction hemi-channel activity
I0055085biological_processtransmembrane transport
I1990349biological_processgap junction-mediated intercellular transport
J0005243molecular_functiongap junction channel activity
J0005515molecular_functionprotein binding
J0005886cellular_componentplasma membrane
J0005921cellular_componentgap junction
J0005922cellular_componentconnexin complex
J0007154biological_processcell communication
J0007267biological_processcell-cell signaling
J0007601biological_processvisual perception
J0055077molecular_functiongap junction hemi-channel activity
J0055085biological_processtransmembrane transport
J1990349biological_processgap junction-mediated intercellular transport
K0005243molecular_functiongap junction channel activity
K0005515molecular_functionprotein binding
K0005886cellular_componentplasma membrane
K0005921cellular_componentgap junction
K0005922cellular_componentconnexin complex
K0007154biological_processcell communication
K0007267biological_processcell-cell signaling
K0007601biological_processvisual perception
K0055077molecular_functiongap junction hemi-channel activity
K0055085biological_processtransmembrane transport
K1990349biological_processgap junction-mediated intercellular transport
L0005243molecular_functiongap junction channel activity
L0005515molecular_functionprotein binding
L0005886cellular_componentplasma membrane
L0005921cellular_componentgap junction
L0005922cellular_componentconnexin complex
L0007154biological_processcell communication
L0007267biological_processcell-cell signaling
L0007601biological_processvisual perception
L0055077molecular_functiongap junction hemi-channel activity
L0055085biological_processtransmembrane transport
L1990349biological_processgap junction-mediated intercellular transport
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DSDGEGAVTavEL
ChainResidueDetails
AASP370-LEU382

site_idPS00407
Number of Residues14
DetailsCONNEXINS_1 Connexins signature 1. CNTqQPGCenVCYD
ChainResidueDetails
ACYS54-ASP67

site_idPS00408
Number of Residues17
DetailsCONNEXINS_2 Connexins signature 2. Cdrw.PCpntVDCFISRP
ChainResidueDetails
ACYS178-PRO194

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues156
DetailsINTRAMEM: INTRAMEM => ECO:0000269|PubMed:30542154
ChainResidueDetails
AGLY2-GLN15
JGLY2-GLN15
KGLY2-GLN15
LGLY2-GLN15
BGLY2-GLN15
CGLY2-GLN15
DGLY2-GLN15
EGLY2-GLN15
FGLY2-GLN15
GGLY2-GLN15
HGLY2-GLN15
IGLY2-GLN15

site_idSWS_FT_FI2
Number of Residues3024
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30542154
ChainResidueDetails
AGLU16-THR19
DGLU16-THR19
DLEU93-ASN149
DTYR220-ILE413
EGLU16-THR19
ELEU93-ASN149
ETYR220-ILE413
FGLU16-THR19
FLEU93-ASN149
FTYR220-ILE413
GGLU16-THR19
ALEU93-ASN149
GLEU93-ASN149
GTYR220-ILE413
HGLU16-THR19
HLEU93-ASN149
HTYR220-ILE413
IGLU16-THR19
ILEU93-ASN149
ITYR220-ILE413
JGLU16-THR19
JLEU93-ASN149
ATYR220-ILE413
JTYR220-ILE413
KGLU16-THR19
KLEU93-ASN149
KTYR220-ILE413
LGLU16-THR19
LLEU93-ASN149
LTYR220-ILE413
BGLU16-THR19
BLEU93-ASN149
BTYR220-ILE413
CGLU16-THR19
CLEU93-ASN149
CTYR220-ILE413

site_idSWS_FT_FI3
Number of Residues960
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:30542154
ChainResidueDetails
AVAL20-ALA40
CILE72-TYR92
CILE150-PHE170
CILE199-ILE219
DVAL20-ALA40
DILE72-TYR92
DILE150-PHE170
DILE199-ILE219
EVAL20-ALA40
EILE72-TYR92
EILE150-PHE170
AILE72-TYR92
EILE199-ILE219
FVAL20-ALA40
FILE72-TYR92
FILE150-PHE170
FILE199-ILE219
GVAL20-ALA40
GILE72-TYR92
GILE150-PHE170
GILE199-ILE219
HVAL20-ALA40
AILE150-PHE170
HILE72-TYR92
HILE150-PHE170
HILE199-ILE219
IVAL20-ALA40
IILE72-TYR92
IILE150-PHE170
IILE199-ILE219
JVAL20-ALA40
JILE72-TYR92
JILE150-PHE170
AILE199-ILE219
JILE199-ILE219
KVAL20-ALA40
KILE72-TYR92
KILE150-PHE170
KILE199-ILE219
LVAL20-ALA40
LILE72-TYR92
LILE150-PHE170
LILE199-ILE219
BVAL20-ALA40
BILE72-TYR92
BILE150-PHE170
BILE199-ILE219
CVAL20-ALA40

site_idSWS_FT_FI4
Number of Residues684
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:30542154
ChainResidueDetails
AALA41-PRO71
EGLN171-THR198
FALA41-PRO71
FGLN171-THR198
GALA41-PRO71
GGLN171-THR198
HALA41-PRO71
HGLN171-THR198
IALA41-PRO71
IGLN171-THR198
JALA41-PRO71
AGLN171-THR198
JGLN171-THR198
KALA41-PRO71
KGLN171-THR198
LALA41-PRO71
LGLN171-THR198
BALA41-PRO71
BGLN171-THR198
CALA41-PRO71
CGLN171-THR198
DALA41-PRO71
DGLN171-THR198
EALA41-PRO71

222036

PDB entries from 2024-07-03

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