7JH2
CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C IN COMPLEX WITH A POTENT, SELECTIVE AND ORALLY BIOAVAILABLE ROR-GAMMA-T INVERSE AGONIST
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue VBG A 501 |
| Chain | Residue |
| A | CYS264 |
| A | LEU341 |
| A | MET344 |
| A | ARG346 |
| A | ALA347 |
| A | PHE357 |
| A | PHE367 |
| A | LEU370 |
| A | LEU375 |
| A | ILE376 |
| A | ILE379 |
| A | GLN265 |
| A | PHE380 |
| A | LEU454 |
| A | CYS455 |
| A | SO4502 |
| A | LEU266 |
| A | LEU271 |
| A | TRP296 |
| A | CYS299 |
| A | HIS302 |
| A | LEU303 |
| A | MET337 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | HIS302 |
| A | PHE356 |
| A | PHE357 |
| A | GLU358 |
| A | VBG501 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | binding site for residue VBG B 501 |
| Chain | Residue |
| B | CYS264 |
| B | GLN265 |
| B | LEU266 |
| B | TRP296 |
| B | CYS299 |
| B | HIS302 |
| B | LEU303 |
| B | ALA306 |
| B | MET337 |
| B | MET344 |
| B | ARG346 |
| B | ALA347 |
| B | PHE357 |
| B | PHE367 |
| B | LEU370 |
| B | LEU375 |
| B | ILE376 |
| B | ILE379 |
| B | PHE380 |
| B | LEU454 |
| B | CYS455 |
| B | LEU462 |
| B | SO4502 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | HIS302 |
| B | PHE356 |
| B | PHE357 |
| B | GLU358 |
| B | VBG501 |
