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7G0W

Crystal Structure of apo human FABP1i monoclinic form II, twinned with beta=90deg

Functional Information from GO Data
ChainGOidnamespacecontents
A0003682molecular_functionchromatin binding
A0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
A0005504molecular_functionfatty acid binding
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005782cellular_componentperoxisomal matrix
A0005829cellular_componentcytosol
A0008289molecular_functionlipid binding
A0015908biological_processfatty acid transport
A0015909biological_processlong-chain fatty acid transport
A0016209molecular_functionantioxidant activity
A0032000biological_processpositive regulation of fatty acid beta-oxidation
A0032052molecular_functionbile acid binding
A0032991cellular_componentprotein-containing complex
A0033552biological_processresponse to vitamin B3
A0043066biological_processnegative regulation of apoptotic process
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0045179cellular_componentapical cortex
A0050892biological_processintestinal absorption
A0070062cellular_componentextracellular exosome
A0070301biological_processcellular response to hydrogen peroxide
A0070538molecular_functionoleic acid binding
A0071456biological_processcellular response to hypoxia
A0098869biological_processcellular oxidant detoxification
A1901363molecular_functionheterocyclic compound binding
B0003682molecular_functionchromatin binding
B0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
B0005504molecular_functionfatty acid binding
B0005515molecular_functionprotein binding
B0005543molecular_functionphospholipid binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005782cellular_componentperoxisomal matrix
B0005829cellular_componentcytosol
B0008289molecular_functionlipid binding
B0015908biological_processfatty acid transport
B0015909biological_processlong-chain fatty acid transport
B0016209molecular_functionantioxidant activity
B0032000biological_processpositive regulation of fatty acid beta-oxidation
B0032052molecular_functionbile acid binding
B0032991cellular_componentprotein-containing complex
B0033552biological_processresponse to vitamin B3
B0043066biological_processnegative regulation of apoptotic process
B0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B0045179cellular_componentapical cortex
B0050892biological_processintestinal absorption
B0070062cellular_componentextracellular exosome
B0070301biological_processcellular response to hydrogen peroxide
B0070538molecular_functionoleic acid binding
B0071456biological_processcellular response to hypoxia
B0098869biological_processcellular oxidant detoxification
B1901363molecular_functionheterocyclic compound binding
C0003682molecular_functionchromatin binding
C0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
C0005504molecular_functionfatty acid binding
C0005515molecular_functionprotein binding
C0005543molecular_functionphospholipid binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005782cellular_componentperoxisomal matrix
C0005829cellular_componentcytosol
C0008289molecular_functionlipid binding
C0015908biological_processfatty acid transport
C0015909biological_processlong-chain fatty acid transport
C0016209molecular_functionantioxidant activity
C0032000biological_processpositive regulation of fatty acid beta-oxidation
C0032052molecular_functionbile acid binding
C0032991cellular_componentprotein-containing complex
C0033552biological_processresponse to vitamin B3
C0043066biological_processnegative regulation of apoptotic process
C0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
C0045179cellular_componentapical cortex
C0050892biological_processintestinal absorption
C0070062cellular_componentextracellular exosome
C0070301biological_processcellular response to hydrogen peroxide
C0070538molecular_functionoleic acid binding
C0071456biological_processcellular response to hypoxia
C0098869biological_processcellular oxidant detoxification
C1901363molecular_functionheterocyclic compound binding
D0003682molecular_functionchromatin binding
D0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
D0005504molecular_functionfatty acid binding
D0005515molecular_functionprotein binding
D0005543molecular_functionphospholipid binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005782cellular_componentperoxisomal matrix
D0005829cellular_componentcytosol
D0008289molecular_functionlipid binding
D0015908biological_processfatty acid transport
D0015909biological_processlong-chain fatty acid transport
D0016209molecular_functionantioxidant activity
D0032000biological_processpositive regulation of fatty acid beta-oxidation
D0032052molecular_functionbile acid binding
D0032991cellular_componentprotein-containing complex
D0033552biological_processresponse to vitamin B3
D0043066biological_processnegative regulation of apoptotic process
D0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
D0045179cellular_componentapical cortex
D0050892biological_processintestinal absorption
D0070062cellular_componentextracellular exosome
D0070301biological_processcellular response to hydrogen peroxide
D0070538molecular_functionoleic acid binding
D0071456biological_processcellular response to hypoxia
D0098869biological_processcellular oxidant detoxification
D1901363molecular_functionheterocyclic compound binding
Functional Information from PROSITE/UniProt
site_idPS00214
Number of Residues18
DetailsFABP Cytosolic fatty-acid binding proteins signature. GKYqLqsQeNFEaFMKAI
ChainResidueDetails
AGLY5-ILE22

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:3838309
ChainResidueDetails
AMET1
BMET1
CMET1
DMET1

site_idSWS_FT_FI2
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER11
ASER56
BSER11
BSER56
CSER11
CSER56
DSER11
DSER56

site_idSWS_FT_FI3
Number of Residues28
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P12710
ChainResidueDetails
ALYS31
ALYS36
ALYS46
ALYS57
ALYS78
ALYS90
ALYS121
BLYS31
BLYS36
BLYS46
BLYS57
BLYS78
BLYS90
BLYS121
CLYS31
CLYS36
CLYS46
CLYS57
CLYS78
CLYS90
CLYS121
DLYS31
DLYS36
DLYS46
DLYS57
DLYS78
DLYS90
DLYS121

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02692
ChainResidueDetails
ASER39
BSER39
CSER39
DSER39

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR51
BTHR51
CTHR51
DTHR51

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P12710
ChainResidueDetails
ASER100
BSER100
CSER100
DSER100

219869

PDB entries from 2024-05-15

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