7FZV

Crystal Structure of human FABP4 in complex with 1-[(2,4-dichlorophenyl)methyl]-4-hydroxy-3-[(E)-3-phenylprop-2-enyl]pyridin-2-one, i.e. SMILES C1(=C(C=CN(C1=O)Cc1c(cc(cc1)Cl)Cl)O)C/C=C/c1ccccc1 with IC50=0.557 microM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005319	molecular_function	lipid transporter activity
A	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
A	0005504	molecular_function	fatty acid binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0008289	molecular_function	lipid binding
A	0015908	biological_process	fatty acid transport
A	0015909	biological_process	long-chain fatty acid transport
A	0019433	biological_process	triglyceride catabolic process
A	0036041	molecular_function	long-chain fatty acid binding
A	0051427	molecular_function	hormone receptor binding
A	0060229	molecular_function	lipase activator activity
A	0070062	cellular_component	extracellular exosome
A	0070343	biological_process	white fat cell proliferation
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	0005319	molecular_function	lipid transporter activity
B	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
B	0005504	molecular_function	fatty acid binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0008289	molecular_function	lipid binding
B	0015908	biological_process	fatty acid transport
B	0015909	biological_process	long-chain fatty acid transport
B	0019433	biological_process	triglyceride catabolic process
B	0036041	molecular_function	long-chain fatty acid binding
B	0051427	molecular_function	hormone receptor binding
B	0060229	molecular_function	lipase activator activity
B	0070062	cellular_component	extracellular exosome
B	0070343	biological_process	white fat cell proliferation
B	0120162	biological_process	positive regulation of cold-induced thermogenesis

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GTWkLvsSeNFDdYMKEV

Chain	Residue	Details
A	GLY6-VAL23

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N-acetylcysteine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P04117","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---