7FTO
Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(2-chloro-5-fluoro-4-methylphenyl)-1H-benzimidazole-4-carboxylic acid
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8C6L5 |
Chain | Residue | Details |
A | THR211 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30007416, ECO:0007744|PDB:6CTA |
Chain | Residue | Details |
A | SER213 | |
A | SER380 | |
A | LYS414 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30007416, ECO:0000305|PubMed:23722159, ECO:0000305|PubMed:26229115, ECO:0007744|PDB:6CT9, ECO:0007744|PDB:6CTA |
Chain | Residue | Details |
A | GLU225 | |
A | ASP227 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30007416, ECO:0007744|PDB:6CT9, ECO:0007744|PDB:6CTA |
Chain | Residue | Details |
A | ASP319 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:31113940, ECO:0007744|PDB:4O67, ECO:0007744|PDB:6MJX |
Chain | Residue | Details |
A | LYS362 | |
A | ARG376 |
Chain | Residue | Details |
A | HIS390 |
Chain | Residue | Details |
A | CYS396 | |
A | CYS397 | |
A | CYS404 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30007416, ECO:0000305|PubMed:24462292, ECO:0007744|PDB:6CTA |
Chain | Residue | Details |
A | SER435 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | SITE: Important for preferential detection of curved long DNA => ECO:0000269|PubMed:30007416 |
Chain | Residue | Details |
A | LYS187 | |
A | LEU195 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | SITE: Arginine-anchor => ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33051594 |
Chain | Residue | Details |
A | ARG255 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | SITE: Cleavage; by CASP3 => ECO:0000269|PubMed:30878284 |
Chain | Residue | Details |
A | ASP319 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | MOD_RES: PolyADP-ribosyl aspartic acid => ECO:0000269|PubMed:35460603 |
Chain | Residue | Details |
A | ASP191 |
site_id | SWS_FT_FI13 |
Number of Residues | 2 |
Details | MOD_RES: (Microbial infection) Deamidated asparagine; by herpes simplex virus 1/HHV-1 UL37 => ECO:0000269|PubMed:30092200 |
Chain | Residue | Details |
A | ASN210 | |
A | ASN389 |
site_id | SWS_FT_FI14 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:33273464 |
Chain | Residue | Details |
A | SER213 |
site_id | SWS_FT_FI15 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine; by BLK => ECO:0000269|PubMed:30356214 |
Chain | Residue | Details |
A | TYR215 |
site_id | SWS_FT_FI16 |
Number of Residues | 1 |
Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q8C6L5 |
Chain | Residue | Details |
A | GLU286 |
site_id | SWS_FT_FI17 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by CDK1 and PKB => ECO:0000269|PubMed:26440888, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:33542149 |
Chain | Residue | Details |
A | SER305 |
site_id | SWS_FT_FI18 |
Number of Residues | 1 |
Details | MOD_RES: 5-glutamyl glutamate => ECO:0000250|UniProtKB:Q8C6L5 |
Chain | Residue | Details |
A | GLU314 |
site_id | SWS_FT_FI19 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30799039 |
Chain | Residue | Details |
A | LYS384 | |
A | LYS392 | |
A | LYS394 |
site_id | SWS_FT_FI20 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30799039, ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS414 |
site_id | SWS_FT_FI21 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:32474700 |
Chain | Residue | Details |
A | SER434 | |
A | SER435 |
site_id | SWS_FT_FI22 |
Number of Residues | 2 |
Details | MOD_RES: (Microbial infection) Deamidated glutamine; by herpes simplex virus 1/HHV-1 UL37 => ECO:0000269|PubMed:30092200 |
Chain | Residue | Details |
A | GLN451 | |
A | GLN454 |
site_id | SWS_FT_FI23 |
Number of Residues | 1 |
Details | MOD_RES: N6-methyllysine => ECO:0000269|PubMed:35210392 |
Chain | Residue | Details |
A | LYS506 |
site_id | SWS_FT_FI24 |
Number of Residues | 2 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:37802025 |
Chain | Residue | Details |
A | CYS404 | |
A | CYS405 |
site_id | SWS_FT_FI25 |
Number of Residues | 1 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:35438208 |
Chain | Residue | Details |
A | CYS474 |
site_id | SWS_FT_FI26 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:28273161 |
Chain | Residue | Details |
A | LYS173 |
site_id | SWS_FT_FI27 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:27637147 |
Chain | Residue | Details |
A | LYS479 |
site_id | SWS_FT_FI28 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:27637147 |
Chain | Residue | Details |
A | LYS231 |
site_id | SWS_FT_FI29 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:27637147 |
Chain | Residue | Details |
A | LYS285 |
site_id | SWS_FT_FI30 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:Q8C6L5 |
Chain | Residue | Details |
A | LYS347 |
site_id | SWS_FT_FI31 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:28273161 |
Chain | Residue | Details |
A | LYS384 |
site_id | SWS_FT_FI32 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q8C6L5 |
Chain | Residue | Details |
A | LYS394 |
site_id | SWS_FT_FI33 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:35503863 |
Chain | Residue | Details |
A | LYS411 |
site_id | SWS_FT_FI34 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:27666593 |
Chain | Residue | Details |
A | LYS414 |
site_id | SWS_FT_FI35 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:38418882 |
Chain | Residue | Details |
A | LYS427 | |
A | LYS428 |