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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7FTI

Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-(4-fluorophenyl)-2-methylpyrazole-3-carboxylic acid

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues42
DetailsRegion: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23707061","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues23
DetailsRegion: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"23707061","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues5
DetailsMotif: {"description":"Nuclear export signal","evidences":[{"source":"PubMed","id":"33406424","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues10
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"30356214","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsMotif: {"description":"KRKR-loop","evidences":[{"source":"PubMed","id":"31142647","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsMotif: {"description":"KKH-loop","evidences":[{"source":"PubMed","id":"31142647","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23722159","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26229115","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6CT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31113940","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4O67","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23707061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24332030","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28934246","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28940468","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31113940","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31142647","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32912999","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5V8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EDC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NFG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Y5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Y5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23707061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24332030","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28934246","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28940468","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31113940","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31142647","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32459092","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32912999","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5V8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EDC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6LRC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NFG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O47","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Y5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Y5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsSite: {"description":"Important for preferential detection of curved long DNA","evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsSite: {"description":"Arginine-anchor","evidences":[{"source":"PubMed","id":"32911482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32912999","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33051594","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsSite: {"description":"Cleavage; by CASP3","evidences":[{"source":"PubMed","id":"30878284","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"PolyADP-ribosyl aspartic acid","evidences":[{"source":"PubMed","id":"35460603","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) Deamidated asparagine; by herpes simplex virus 1/HHV-1 UL37","evidences":[{"source":"PubMed","id":"30092200","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"33273464","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by BLK","evidences":[{"source":"PubMed","id":"30356214","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsModified residue: {"description":"5-glutamyl polyglutamate","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by CDK1 and PKB","evidences":[{"source":"PubMed","id":"26440888","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32351706","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33542149","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues1
DetailsModified residue: {"description":"5-glutamyl glutamate","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30799039","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30799039","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"32474700","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) Deamidated glutamine; by herpes simplex virus 1/HHV-1 UL37","evidences":[{"source":"PubMed","id":"30092200","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues1
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"35210392","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues2
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"37802025","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues1
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"35438208","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"28273161","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI35
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI36
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI37
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI38
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"28273161","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI39
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI40
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"35503863","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI41
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"27666593","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI42
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"38418882","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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