7FSE
Crystal Structure of T. maritima reverse gyrase with a minimal latch
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003916 | molecular_function | DNA topoisomerase activity |
| A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006260 | biological_process | DNA replication |
| A | 0006265 | biological_process | DNA topological change |
| A | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0160097 | molecular_function | reverse gyrase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00572 |
| Number of Residues | 9 |
| Details | GLYCOSYL_HYDROL_F1_1 Glycosyl hydrolases family 1 active site. LLVLENGVN |
| Chain | Residue | Details |
| A | LEU717-ASN725 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 155 |
| Details | Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_01125","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 157 |
| Details | Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_01125","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 386 |
| Details | Domain: {"description":"Topo IA-type catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU01383","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 27 |
| Details | Zinc finger: {"description":"RG C-terminal-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01381","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23209025","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 27 |
| Details | Region: {"description":"Insert region","evidences":[{"source":"PubMed","id":"23209025","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Motif: {"description":"DEAD box","evidences":[{"source":"HAMAP-Rule","id":"MF_01125","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01383","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18614530","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01125","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23209025","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7FSE","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7FSF","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8OFB","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4DDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DDV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DDX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21627332","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3P4X","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01125","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
