7FQJ

Crystal Structure of human Legumain in complex with (2S)-N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[1-[4-[(2,4-difluorophenyl)methoxy]phenyl]cyclopropanecarbonyl]pyrrolidine-2-carboxamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003014	biological_process	renal system process
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005770	cellular_component	late endosome
A	0006508	biological_process	proteolysis
A	0006624	biological_process	vacuolar protein processing
A	0007613	biological_process	memory
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008306	biological_process	associative learning
A	0010447	biological_process	response to acidic pH
A	0010629	biological_process	negative regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
A	0032801	biological_process	receptor catabolic process
A	0035729	biological_process	cellular response to hepatocyte growth factor stimulus
A	0036021	cellular_component	endolysosome lumen
A	0042359	biological_process	vitamin D metabolic process
A	0043202	cellular_component	lysosomal lumen
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0045177	cellular_component	apical part of cell
A	0045931	biological_process	positive regulation of mitotic cell cycle
A	0048156	molecular_function	tau protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0051604	biological_process	protein maturation
A	0061133	molecular_function	endopeptidase activator activity
A	0070062	cellular_component	extracellular exosome
A	0071277	biological_process	cellular response to calcium ion
A	0090026	biological_process	positive regulation of monocyte chemotaxis
A	0097061	biological_process	dendritic spine organization
A	1900273	biological_process	positive regulation of long-term synaptic potentiation
A	1901185	biological_process	negative regulation of ERBB signaling pathway
A	1904646	biological_process	cellular response to amyloid-beta
A	2001028	biological_process	positive regulation of endothelial cell chemotaxis
B	0003014	biological_process	renal system process
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005770	cellular_component	late endosome
B	0006508	biological_process	proteolysis
B	0006624	biological_process	vacuolar protein processing
B	0007613	biological_process	memory
B	0008233	molecular_function	peptidase activity
B	0008234	molecular_function	cysteine-type peptidase activity
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008306	biological_process	associative learning
B	0010447	biological_process	response to acidic pH
B	0010629	biological_process	negative regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0032801	biological_process	receptor catabolic process
B	0035729	biological_process	cellular response to hepatocyte growth factor stimulus
B	0036021	cellular_component	endolysosome lumen
B	0042359	biological_process	vitamin D metabolic process
B	0043202	cellular_component	lysosomal lumen
B	0043524	biological_process	negative regulation of neuron apoptotic process
B	0045177	cellular_component	apical part of cell
B	0045931	biological_process	positive regulation of mitotic cell cycle
B	0048156	molecular_function	tau protein binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0051604	biological_process	protein maturation
B	0061133	molecular_function	endopeptidase activator activity
B	0070062	cellular_component	extracellular exosome
B	0071277	biological_process	cellular response to calcium ion
B	0090026	biological_process	positive regulation of monocyte chemotaxis
B	0097061	biological_process	dendritic spine organization
B	1900273	biological_process	positive regulation of long-term synaptic potentiation
B	1901185	biological_process	negative regulation of ERBB signaling pathway
B	1904646	biological_process	cellular response to amyloid-beta
B	2001028	biological_process	positive regulation of endothelial cell chemotaxis
C	0003014	biological_process	renal system process
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005770	cellular_component	late endosome
C	0006508	biological_process	proteolysis
C	0006624	biological_process	vacuolar protein processing
C	0007613	biological_process	memory
C	0008233	molecular_function	peptidase activity
C	0008234	molecular_function	cysteine-type peptidase activity
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008306	biological_process	associative learning
C	0010447	biological_process	response to acidic pH
C	0010629	biological_process	negative regulation of gene expression
C	0016787	molecular_function	hydrolase activity
C	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
C	0032801	biological_process	receptor catabolic process
C	0035729	biological_process	cellular response to hepatocyte growth factor stimulus
C	0036021	cellular_component	endolysosome lumen
C	0042359	biological_process	vitamin D metabolic process
C	0043202	cellular_component	lysosomal lumen
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0045177	cellular_component	apical part of cell
C	0045931	biological_process	positive regulation of mitotic cell cycle
C	0048156	molecular_function	tau protein binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0051604	biological_process	protein maturation
C	0061133	molecular_function	endopeptidase activator activity
C	0070062	cellular_component	extracellular exosome
C	0071277	biological_process	cellular response to calcium ion
C	0090026	biological_process	positive regulation of monocyte chemotaxis
C	0097061	biological_process	dendritic spine organization
C	1900273	biological_process	positive regulation of long-term synaptic potentiation
C	1901185	biological_process	negative regulation of ERBB signaling pathway
C	1904646	biological_process	cellular response to amyloid-beta
C	2001028	biological_process	positive regulation of endothelial cell chemotaxis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"evidences":[{"source":"PubMed","id":"23776206","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"23776206","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23776206","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23776206","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---