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7FQJ

Crystal Structure of human Legumain in complex with (2S)-N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[1-[4-[(2,4-difluorophenyl)methoxy]phenyl]cyclopropanecarbonyl]pyrrolidine-2-carboxamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0003014biological_processrenal system process
A0004175molecular_functionendopeptidase activity
A0004197molecular_functioncysteine-type endopeptidase activity
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005770cellular_componentlate endosome
A0006508biological_processproteolysis
A0006624biological_processvacuolar protein processing
A0007613biological_processmemory
A0008233molecular_functionpeptidase activity
A0008234molecular_functioncysteine-type peptidase activity
A0008284biological_processpositive regulation of cell population proliferation
A0008306biological_processassociative learning
A0010447biological_processresponse to acidic pH
A0010629biological_processnegative regulation of gene expression
A0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
A0032801biological_processreceptor catabolic process
A0035729biological_processcellular response to hepatocyte growth factor stimulus
A0036021cellular_componentendolysosome lumen
A0040015biological_processnegative regulation of multicellular organism growth
A0042359biological_processvitamin D metabolic process
A0043202cellular_componentlysosomal lumen
A0043524biological_processnegative regulation of neuron apoptotic process
A0045177cellular_componentapical part of cell
A0045931biological_processpositive regulation of mitotic cell cycle
A0048156molecular_functiontau protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0051603biological_processproteolysis involved in protein catabolic process
A0051604biological_processprotein maturation
A0061133molecular_functionendopeptidase activator activity
A0070062cellular_componentextracellular exosome
A0071277biological_processcellular response to calcium ion
A0090026biological_processpositive regulation of monocyte chemotaxis
A0097061biological_processdendritic spine organization
A0097202biological_processactivation of cysteine-type endopeptidase activity
A0097264biological_processself proteolysis
A1900273biological_processpositive regulation of long-term synaptic potentiation
A1901185biological_processnegative regulation of ERBB signaling pathway
A1904646biological_processcellular response to amyloid-beta
A2001028biological_processpositive regulation of endothelial cell chemotaxis
B0003014biological_processrenal system process
B0004175molecular_functionendopeptidase activity
B0004197molecular_functioncysteine-type endopeptidase activity
B0005576cellular_componentextracellular region
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005770cellular_componentlate endosome
B0006508biological_processproteolysis
B0006624biological_processvacuolar protein processing
B0007613biological_processmemory
B0008233molecular_functionpeptidase activity
B0008234molecular_functioncysteine-type peptidase activity
B0008284biological_processpositive regulation of cell population proliferation
B0008306biological_processassociative learning
B0010447biological_processresponse to acidic pH
B0010629biological_processnegative regulation of gene expression
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0032801biological_processreceptor catabolic process
B0035729biological_processcellular response to hepatocyte growth factor stimulus
B0036021cellular_componentendolysosome lumen
B0040015biological_processnegative regulation of multicellular organism growth
B0042359biological_processvitamin D metabolic process
B0043202cellular_componentlysosomal lumen
B0043524biological_processnegative regulation of neuron apoptotic process
B0045177cellular_componentapical part of cell
B0045931biological_processpositive regulation of mitotic cell cycle
B0048156molecular_functiontau protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0051603biological_processproteolysis involved in protein catabolic process
B0051604biological_processprotein maturation
B0061133molecular_functionendopeptidase activator activity
B0070062cellular_componentextracellular exosome
B0071277biological_processcellular response to calcium ion
B0090026biological_processpositive regulation of monocyte chemotaxis
B0097061biological_processdendritic spine organization
B0097202biological_processactivation of cysteine-type endopeptidase activity
B0097264biological_processself proteolysis
B1900273biological_processpositive regulation of long-term synaptic potentiation
B1901185biological_processnegative regulation of ERBB signaling pathway
B1904646biological_processcellular response to amyloid-beta
B2001028biological_processpositive regulation of endothelial cell chemotaxis
C0003014biological_processrenal system process
C0004175molecular_functionendopeptidase activity
C0004197molecular_functioncysteine-type endopeptidase activity
C0005576cellular_componentextracellular region
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005770cellular_componentlate endosome
C0006508biological_processproteolysis
C0006624biological_processvacuolar protein processing
C0007613biological_processmemory
C0008233molecular_functionpeptidase activity
C0008234molecular_functioncysteine-type peptidase activity
C0008284biological_processpositive regulation of cell population proliferation
C0008306biological_processassociative learning
C0010447biological_processresponse to acidic pH
C0010629biological_processnegative regulation of gene expression
C0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
C0032801biological_processreceptor catabolic process
C0035729biological_processcellular response to hepatocyte growth factor stimulus
C0036021cellular_componentendolysosome lumen
C0040015biological_processnegative regulation of multicellular organism growth
C0042359biological_processvitamin D metabolic process
C0043202cellular_componentlysosomal lumen
C0043524biological_processnegative regulation of neuron apoptotic process
C0045177cellular_componentapical part of cell
C0045931biological_processpositive regulation of mitotic cell cycle
C0048156molecular_functiontau protein binding
C0048471cellular_componentperinuclear region of cytoplasm
C0051603biological_processproteolysis involved in protein catabolic process
C0051604biological_processprotein maturation
C0061133molecular_functionendopeptidase activator activity
C0070062cellular_componentextracellular exosome
C0071277biological_processcellular response to calcium ion
C0090026biological_processpositive regulation of monocyte chemotaxis
C0097061biological_processdendritic spine organization
C0097202biological_processactivation of cysteine-type endopeptidase activity
C0097264biological_processself proteolysis
C1900273biological_processpositive regulation of long-term synaptic potentiation
C1901185biological_processnegative regulation of ERBB signaling pathway
C1904646biological_processcellular response to amyloid-beta
C2001028biological_processpositive regulation of endothelial cell chemotaxis
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: ACT_SITE => ECO:0000305|PubMed:23776206
ChainResidueDetails
AHIS148
BHIS148
CHIS148

site_idSWS_FT_FI2
Number of Residues3
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:23776206
ChainResidueDetails
ACYS189
BCYS189
CCYS189

site_idSWS_FT_FI3
Number of Residues3
DetailsSITE: Cleavage; by autolysis => ECO:0000269|PubMed:11085925
ChainResidueDetails
AASN323
BASN323
CASN323

site_idSWS_FT_FI4
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:23776206
ChainResidueDetails
AASN91
AASN167
BASN91
BASN167
CASN91
CASN167

site_idSWS_FT_FI5
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23776206
ChainResidueDetails
AASN263
AGLN272
BASN263
BGLN272
CASN263
CGLN272

222624

PDB entries from 2024-07-17

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