7FJ2

Structure of FOXM1 homodimer bound to a palindromic DNA site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000086	biological_process	G2/M transition of mitotic cell cycle
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0043565	molecular_function	sequence-specific DNA binding
B	0000086	biological_process	G2/M transition of mitotic cell cycle
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0043565	molecular_function	sequence-specific DNA binding
E	0000086	biological_process	G2/M transition of mitotic cell cycle
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006355	biological_process	regulation of DNA-templated transcription
E	0043565	molecular_function	sequence-specific DNA binding
F	0000086	biological_process	G2/M transition of mitotic cell cycle
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0006355	biological_process	regulation of DNA-templated transcription
F	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00657
Number of Residues	14
Details	FORK_HEAD_1 Fork head domain signature 1. RPPYSYmaMiqf.AI

Chain	Residue	Details
A	ARG236-ILE249

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site_id	PS00658
Number of Residues	7
Details	FORK_HEAD_2 Fork head domain signature 2. WKNSIRH

Chain	Residue	Details
A	TRP281-HIS287

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	368
Details	DNA_BIND: Fork-head => ECO:0000255|PROSITE-ProRule:PRU00089

Chain	Residue	Details
A	GLU235-LEU327
B	GLU235-LEU327
E	GLU235-LEU327
F	GLU235-LEU327

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER331
B	SER331
E	SER331
F	SER331

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site_id	SWS_FT_FI3
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS325
B	LYS325
E	LYS325
F	LYS325

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