7FIK

The cryo-EM structure of the CR subunit from X. laevis NPC

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0005634	cellular_component	nucleus
a	0005643	cellular_component	nuclear pore
a	0006913	biological_process	nucleocytoplasmic transport
a	0006999	biological_process	nuclear pore organization
a	0017056	molecular_function	structural constituent of nuclear pore
a	0044611	cellular_component	nuclear pore inner ring
A	0005634	cellular_component	nucleus
A	0005643	cellular_component	nuclear pore
A	0006913	biological_process	nucleocytoplasmic transport
A	0006999	biological_process	nuclear pore organization
A	0017056	molecular_function	structural constituent of nuclear pore
A	0044611	cellular_component	nuclear pore inner ring
b	0005643	cellular_component	nuclear pore
b	0005829	cellular_component	cytosol
b	0006406	biological_process	mRNA export from nucleus
b	0006606	biological_process	protein import into nucleus
b	0017056	molecular_function	structural constituent of nuclear pore
b	0031080	cellular_component	nuclear pore outer ring
b	0031965	cellular_component	nuclear membrane
b	0045893	biological_process	positive regulation of DNA-templated transcription
b	0072006	biological_process	nephron development
B	0005643	cellular_component	nuclear pore
B	0005829	cellular_component	cytosol
B	0006406	biological_process	mRNA export from nucleus
B	0006606	biological_process	protein import into nucleus
B	0017056	molecular_function	structural constituent of nuclear pore
B	0031080	cellular_component	nuclear pore outer ring
B	0031965	cellular_component	nuclear membrane
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0072006	biological_process	nephron development
c	0005634	cellular_component	nucleus
c	0005829	cellular_component	cytosol
c	0031080	cellular_component	nuclear pore outer ring
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0031080	cellular_component	nuclear pore outer ring
d	0000776	cellular_component	kinetochore
d	0005198	molecular_function	structural molecule activity
d	0005643	cellular_component	nuclear pore
d	0005765	cellular_component	lysosomal membrane
d	0006999	biological_process	nuclear pore organization
d	0007080	biological_process	mitotic metaphase chromosome alignment
d	0031080	cellular_component	nuclear pore outer ring
d	0031669	biological_process	cellular response to nutrient levels
d	0034198	biological_process	cellular response to amino acid starvation
d	0035859	cellular_component	Seh1-associated complex
d	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
d	0061700	cellular_component	GATOR2 complex
d	1904263	biological_process	positive regulation of TORC1 signaling
D	0000776	cellular_component	kinetochore
D	0005198	molecular_function	structural molecule activity
D	0005643	cellular_component	nuclear pore
D	0005765	cellular_component	lysosomal membrane
D	0006999	biological_process	nuclear pore organization
D	0007080	biological_process	mitotic metaphase chromosome alignment
D	0031080	cellular_component	nuclear pore outer ring
D	0031669	biological_process	cellular response to nutrient levels
D	0034198	biological_process	cellular response to amino acid starvation
D	0035859	cellular_component	Seh1-associated complex
D	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
D	0061700	cellular_component	GATOR2 complex
D	1904263	biological_process	positive regulation of TORC1 signaling
f	0005643	cellular_component	nuclear pore
f	0005829	cellular_component	cytosol
f	0031080	cellular_component	nuclear pore outer ring
F	0005643	cellular_component	nuclear pore
F	0005829	cellular_component	cytosol
F	0031080	cellular_component	nuclear pore outer ring
g	0005643	cellular_component	nuclear pore
g	0006913	biological_process	nucleocytoplasmic transport
g	0017056	molecular_function	structural constituent of nuclear pore
G	0005643	cellular_component	nuclear pore
G	0006913	biological_process	nucleocytoplasmic transport
G	0017056	molecular_function	structural constituent of nuclear pore
h	0005198	molecular_function	structural molecule activity
h	0005643	cellular_component	nuclear pore
h	0005765	cellular_component	lysosomal membrane
h	0006606	biological_process	protein import into nucleus
h	0030127	cellular_component	COPII vesicle coat
h	0031080	cellular_component	nuclear pore outer ring
h	0032008	biological_process	positive regulation of TOR signaling
h	0032527	biological_process	protein exit from endoplasmic reticulum
h	0090114	biological_process	COPII-coated vesicle budding
H	0005198	molecular_function	structural molecule activity
H	0005643	cellular_component	nuclear pore
H	0005765	cellular_component	lysosomal membrane
H	0006606	biological_process	protein import into nucleus
H	0030127	cellular_component	COPII vesicle coat
H	0031080	cellular_component	nuclear pore outer ring
H	0032008	biological_process	positive regulation of TOR signaling
H	0032527	biological_process	protein exit from endoplasmic reticulum
H	0090114	biological_process	COPII-coated vesicle budding
i	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
i	0005643	cellular_component	nuclear pore
i	0005829	cellular_component	cytosol
i	0006406	biological_process	mRNA export from nucleus
i	0006606	biological_process	protein import into nucleus
i	0017056	molecular_function	structural constituent of nuclear pore
i	0031080	cellular_component	nuclear pore outer ring
i	0031965	cellular_component	nuclear membrane
I	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
I	0005643	cellular_component	nuclear pore
I	0005829	cellular_component	cytosol
I	0006406	biological_process	mRNA export from nucleus
I	0006606	biological_process	protein import into nucleus
I	0017056	molecular_function	structural constituent of nuclear pore
I	0031080	cellular_component	nuclear pore outer ring
I	0031965	cellular_component	nuclear membrane
j	0000972	biological_process	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
j	0005643	cellular_component	nuclear pore
j	0005829	cellular_component	cytosol
j	0006606	biological_process	protein import into nucleus
j	0016973	biological_process	poly(A)+ mRNA export from nucleus
j	0017056	molecular_function	structural constituent of nuclear pore
j	0031080	cellular_component	nuclear pore outer ring
j	0048513	biological_process	animal organ development
j	0048731	biological_process	system development
J	0017056	molecular_function	structural constituent of nuclear pore
K	0005096	molecular_function	GTPase activator activity
K	0005643	cellular_component	nuclear pore
K	0005737	cellular_component	cytoplasm
K	0031965	cellular_component	nuclear membrane
K	0046907	biological_process	intracellular transport
L	0005096	molecular_function	GTPase activator activity
L	0005643	cellular_component	nuclear pore
L	0005737	cellular_component	cytoplasm
L	0031965	cellular_component	nuclear membrane
L	0046907	biological_process	intracellular transport
M	0005096	molecular_function	GTPase activator activity
M	0005643	cellular_component	nuclear pore
M	0005737	cellular_component	cytoplasm
M	0031965	cellular_component	nuclear membrane
M	0046907	biological_process	intracellular transport
N	0005096	molecular_function	GTPase activator activity
N	0005643	cellular_component	nuclear pore
N	0005737	cellular_component	cytoplasm
N	0031965	cellular_component	nuclear membrane
N	0046907	biological_process	intracellular transport
O	0005096	molecular_function	GTPase activator activity
O	0005643	cellular_component	nuclear pore
O	0005737	cellular_component	cytoplasm
O	0031965	cellular_component	nuclear membrane
O	0046907	biological_process	intracellular transport
p	0005643	cellular_component	nuclear pore
p	0005829	cellular_component	cytosol
p	0006606	biological_process	protein import into nucleus
p	0016973	biological_process	poly(A)+ mRNA export from nucleus
p	0017056	molecular_function	structural constituent of nuclear pore
p	0031965	cellular_component	nuclear membrane
p	0034399	cellular_component	nuclear periphery
p	0051292	biological_process	nuclear pore complex assembly
P	0005643	cellular_component	nuclear pore
P	0005829	cellular_component	cytosol
P	0006606	biological_process	protein import into nucleus
P	0016973	biological_process	poly(A)+ mRNA export from nucleus
P	0017056	molecular_function	structural constituent of nuclear pore
P	0031965	cellular_component	nuclear membrane
P	0034399	cellular_component	nuclear periphery
P	0051292	biological_process	nuclear pore complex assembly
s	0005643	cellular_component	nuclear pore
s	0005829	cellular_component	cytosol
s	0006606	biological_process	protein import into nucleus
s	0016973	biological_process	poly(A)+ mRNA export from nucleus
s	0017056	molecular_function	structural constituent of nuclear pore
s	0031965	cellular_component	nuclear membrane
s	0034399	cellular_component	nuclear periphery
s	0051292	biological_process	nuclear pore complex assembly
S	0005643	cellular_component	nuclear pore
S	0005829	cellular_component	cytosol
S	0006606	biological_process	protein import into nucleus
S	0016973	biological_process	poly(A)+ mRNA export from nucleus
S	0017056	molecular_function	structural constituent of nuclear pore
S	0031965	cellular_component	nuclear membrane
S	0034399	cellular_component	nuclear periphery
S	0051292	biological_process	nuclear pore complex assembly
W	0000972	biological_process	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
W	0005635	cellular_component	nuclear envelope
W	0005643	cellular_component	nuclear pore
W	0006405	biological_process	RNA export from nucleus
W	0006606	biological_process	protein import into nucleus
W	0006913	biological_process	nucleocytoplasmic transport
W	0017056	molecular_function	structural constituent of nuclear pore
W	0031965	cellular_component	nuclear membrane
W	0036228	biological_process	protein localization to nuclear inner membrane
W	0044611	cellular_component	nuclear pore inner ring
Y	0000055	biological_process	ribosomal large subunit export from nucleus
Y	0000056	biological_process	ribosomal small subunit export from nucleus
Y	0005643	cellular_component	nuclear pore
Y	0006406	biological_process	mRNA export from nucleus
Y	0006606	biological_process	protein import into nucleus
Y	0006913	biological_process	nucleocytoplasmic transport
Y	0017056	molecular_function	structural constituent of nuclear pore

Functional Information from PROSITE/UniProt

site_id	PS00616
Number of Residues	15
Details	HIS_ACID_PHOSPHAT_1 Histidine acid phosphatases phosphohistidine signature. LlyAfhIyRHNyRkA

Chain	Residue	Details
e	LEU1078-ALA1092

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site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VATGgqDgMLCIWDV

Chain	Residue	Details
C	VAL230-VAL244
f	ILE140-LEU154

---

site_id	PS01358
Number of Residues	20
Details	ZF_RANBP2_1 Zinc finger RanBP2-type signature. WqCdc..ClatNaptstsCvcC

Chain	Residue	Details
K	TRP1349-CYS1368
K	TRP1413-CYS1432
K	TRP1474-CYS1493
K	TRP1534-CYS1553
K	TRP1594-CYS1613
K	TRP1661-CYS1680

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	78
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	82
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	100
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	78
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

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