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7FIK

The cryo-EM structure of the CR subunit from X. laevis NPC

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0005643cellular_componentnuclear pore
A0006913biological_processnucleocytoplasmic transport
A0006999biological_processnuclear pore organization
A0017056molecular_functionstructural constituent of nuclear pore
A0044611cellular_componentnuclear pore inner ring
B0005643cellular_componentnuclear pore
B0005829cellular_componentcytosol
B0006406biological_processmRNA export from nucleus
B0006606biological_processprotein import into nucleus
B0015031biological_processprotein transport
B0017056molecular_functionstructural constituent of nuclear pore
B0031080cellular_componentnuclear pore outer ring
B0031965cellular_componentnuclear membrane
B0045893biological_processpositive regulation of DNA-templated transcription
B0051028biological_processmRNA transport
B0072006biological_processnephron development
C0005634cellular_componentnucleus
C0005829cellular_componentcytosol
C0031080cellular_componentnuclear pore outer ring
D0000776cellular_componentkinetochore
D0005198molecular_functionstructural molecule activity
D0005643cellular_componentnuclear pore
D0005765cellular_componentlysosomal membrane
D0006999biological_processnuclear pore organization
D0007059biological_processchromosome segregation
D0007080biological_processmitotic metaphase chromosome alignment
D0015031biological_processprotein transport
D0031080cellular_componentnuclear pore outer ring
D0031669biological_processcellular response to nutrient levels
D0034198biological_processcellular response to amino acid starvation
D0035859cellular_componentSeh1-associated complex
D0051028biological_processmRNA transport
D0051301biological_processcell division
D0051315biological_processattachment of mitotic spindle microtubules to kinetochore
D0061700cellular_componentGATOR2 complex
D1904263biological_processpositive regulation of TORC1 signaling
F0000776cellular_componentkinetochore
F0005643cellular_componentnuclear pore
F0005829cellular_componentcytosol
F0007059biological_processchromosome segregation
F0015031biological_processprotein transport
F0031080cellular_componentnuclear pore outer ring
F0051028biological_processmRNA transport
F0051301biological_processcell division
G0005643cellular_componentnuclear pore
G0006913biological_processnucleocytoplasmic transport
G0017056molecular_functionstructural constituent of nuclear pore
H0005198molecular_functionstructural molecule activity
H0005643cellular_componentnuclear pore
H0005765cellular_componentlysosomal membrane
H0006606biological_processprotein import into nucleus
H0015031biological_processprotein transport
H0030127cellular_componentCOPII vesicle coat
H0031080cellular_componentnuclear pore outer ring
H0032008biological_processpositive regulation of TOR signaling
H0032527biological_processprotein exit from endoplasmic reticulum
H0051028biological_processmRNA transport
H0090114biological_processCOPII-coated vesicle budding
I0000776cellular_componentkinetochore
I0000973biological_processpost-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
I0005643cellular_componentnuclear pore
I0005829cellular_componentcytosol
I0006406biological_processmRNA export from nucleus
I0006606biological_processprotein import into nucleus
I0015031biological_processprotein transport
I0017056molecular_functionstructural constituent of nuclear pore
I0031080cellular_componentnuclear pore outer ring
I0031965cellular_componentnuclear membrane
I0051028biological_processmRNA transport
J0017056molecular_functionstructural constituent of nuclear pore
K0003677molecular_functionDNA binding
K0005096molecular_functionGTPase activator activity
K0005643cellular_componentnuclear pore
K0005737cellular_componentcytoplasm
K0008270molecular_functionzinc ion binding
K0015031biological_processprotein transport
K0031965cellular_componentnuclear membrane
K0046872molecular_functionmetal ion binding
K0046907biological_processintracellular transport
K0051028biological_processmRNA transport
L0003677molecular_functionDNA binding
L0005096molecular_functionGTPase activator activity
L0005643cellular_componentnuclear pore
L0005737cellular_componentcytoplasm
L0008270molecular_functionzinc ion binding
L0015031biological_processprotein transport
L0031965cellular_componentnuclear membrane
L0046872molecular_functionmetal ion binding
L0046907biological_processintracellular transport
L0051028biological_processmRNA transport
M0003677molecular_functionDNA binding
M0005096molecular_functionGTPase activator activity
M0005643cellular_componentnuclear pore
M0005737cellular_componentcytoplasm
M0008270molecular_functionzinc ion binding
M0015031biological_processprotein transport
M0031965cellular_componentnuclear membrane
M0046872molecular_functionmetal ion binding
M0046907biological_processintracellular transport
M0051028biological_processmRNA transport
N0003677molecular_functionDNA binding
N0005096molecular_functionGTPase activator activity
N0005643cellular_componentnuclear pore
N0005737cellular_componentcytoplasm
N0008270molecular_functionzinc ion binding
N0015031biological_processprotein transport
N0031965cellular_componentnuclear membrane
N0046872molecular_functionmetal ion binding
N0046907biological_processintracellular transport
N0051028biological_processmRNA transport
O0003677molecular_functionDNA binding
O0005096molecular_functionGTPase activator activity
O0005643cellular_componentnuclear pore
O0005737cellular_componentcytoplasm
O0008270molecular_functionzinc ion binding
O0015031biological_processprotein transport
O0031965cellular_componentnuclear membrane
O0046872molecular_functionmetal ion binding
O0046907biological_processintracellular transport
O0051028biological_processmRNA transport
P0005643cellular_componentnuclear pore
P0005829cellular_componentcytosol
P0006606biological_processprotein import into nucleus
P0015031biological_processprotein transport
P0016973biological_processpoly(A)+ mRNA export from nucleus
P0017056molecular_functionstructural constituent of nuclear pore
P0031965cellular_componentnuclear membrane
P0034399cellular_componentnuclear periphery
P0051028biological_processmRNA transport
P0051292biological_processnuclear pore complex assembly
S0005643cellular_componentnuclear pore
S0005829cellular_componentcytosol
S0006606biological_processprotein import into nucleus
S0015031biological_processprotein transport
S0016973biological_processpoly(A)+ mRNA export from nucleus
S0017056molecular_functionstructural constituent of nuclear pore
S0031965cellular_componentnuclear membrane
S0034399cellular_componentnuclear periphery
S0051028biological_processmRNA transport
S0051292biological_processnuclear pore complex assembly
W0000972biological_processtranscription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
W0005635cellular_componentnuclear envelope
W0005643cellular_componentnuclear pore
W0006405biological_processRNA export from nucleus
W0006606biological_processprotein import into nucleus
W0006913biological_processnucleocytoplasmic transport
W0015031biological_processprotein transport
W0017056molecular_functionstructural constituent of nuclear pore
W0031965cellular_componentnuclear membrane
W0036228biological_processprotein localization to nuclear inner membrane
W0044611cellular_componentnuclear pore inner ring
W0051028biological_processmRNA transport
Y0000055biological_processribosomal large subunit export from nucleus
Y0000056biological_processribosomal small subunit export from nucleus
Y0005643cellular_componentnuclear pore
Y0006406biological_processmRNA export from nucleus
Y0006606biological_processprotein import into nucleus
Y0006913biological_processnucleocytoplasmic transport
Y0015031biological_processprotein transport
Y0017056molecular_functionstructural constituent of nuclear pore
Y0051028biological_processmRNA transport
a0005634cellular_componentnucleus
a0005643cellular_componentnuclear pore
a0006913biological_processnucleocytoplasmic transport
a0006999biological_processnuclear pore organization
a0017056molecular_functionstructural constituent of nuclear pore
a0044611cellular_componentnuclear pore inner ring
b0005643cellular_componentnuclear pore
b0005829cellular_componentcytosol
b0006406biological_processmRNA export from nucleus
b0006606biological_processprotein import into nucleus
b0015031biological_processprotein transport
b0017056molecular_functionstructural constituent of nuclear pore
b0031080cellular_componentnuclear pore outer ring
b0031965cellular_componentnuclear membrane
b0045893biological_processpositive regulation of DNA-templated transcription
b0051028biological_processmRNA transport
b0072006biological_processnephron development
c0005634cellular_componentnucleus
c0005829cellular_componentcytosol
c0031080cellular_componentnuclear pore outer ring
d0000776cellular_componentkinetochore
d0005198molecular_functionstructural molecule activity
d0005643cellular_componentnuclear pore
d0005765cellular_componentlysosomal membrane
d0006999biological_processnuclear pore organization
d0007059biological_processchromosome segregation
d0007080biological_processmitotic metaphase chromosome alignment
d0015031biological_processprotein transport
d0031080cellular_componentnuclear pore outer ring
d0031669biological_processcellular response to nutrient levels
d0034198biological_processcellular response to amino acid starvation
d0035859cellular_componentSeh1-associated complex
d0051028biological_processmRNA transport
d0051301biological_processcell division
d0051315biological_processattachment of mitotic spindle microtubules to kinetochore
d0061700cellular_componentGATOR2 complex
d1904263biological_processpositive regulation of TORC1 signaling
f0000776cellular_componentkinetochore
f0005643cellular_componentnuclear pore
f0005829cellular_componentcytosol
f0007059biological_processchromosome segregation
f0015031biological_processprotein transport
f0031080cellular_componentnuclear pore outer ring
f0051028biological_processmRNA transport
f0051301biological_processcell division
g0005643cellular_componentnuclear pore
g0006913biological_processnucleocytoplasmic transport
g0017056molecular_functionstructural constituent of nuclear pore
h0005198molecular_functionstructural molecule activity
h0005643cellular_componentnuclear pore
h0005765cellular_componentlysosomal membrane
h0006606biological_processprotein import into nucleus
h0015031biological_processprotein transport
h0030127cellular_componentCOPII vesicle coat
h0031080cellular_componentnuclear pore outer ring
h0032008biological_processpositive regulation of TOR signaling
h0032527biological_processprotein exit from endoplasmic reticulum
h0051028biological_processmRNA transport
h0090114biological_processCOPII-coated vesicle budding
i0000776cellular_componentkinetochore
i0000973biological_processpost-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
i0005643cellular_componentnuclear pore
i0005829cellular_componentcytosol
i0006406biological_processmRNA export from nucleus
i0006606biological_processprotein import into nucleus
i0015031biological_processprotein transport
i0017056molecular_functionstructural constituent of nuclear pore
i0031080cellular_componentnuclear pore outer ring
i0031965cellular_componentnuclear membrane
i0051028biological_processmRNA transport
j0000776cellular_componentkinetochore
j0000972biological_processtranscription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
j0005643cellular_componentnuclear pore
j0005829cellular_componentcytosol
j0006606biological_processprotein import into nucleus
j0015031biological_processprotein transport
j0016973biological_processpoly(A)+ mRNA export from nucleus
j0017056molecular_functionstructural constituent of nuclear pore
j0031080cellular_componentnuclear pore outer ring
j0048513biological_processanimal organ development
j0048731biological_processsystem development
j0051028biological_processmRNA transport
p0005643cellular_componentnuclear pore
p0005829cellular_componentcytosol
p0006606biological_processprotein import into nucleus
p0015031biological_processprotein transport
p0016973biological_processpoly(A)+ mRNA export from nucleus
p0017056molecular_functionstructural constituent of nuclear pore
p0031965cellular_componentnuclear membrane
p0034399cellular_componentnuclear periphery
p0051028biological_processmRNA transport
p0051292biological_processnuclear pore complex assembly
s0005643cellular_componentnuclear pore
s0005829cellular_componentcytosol
s0006606biological_processprotein import into nucleus
s0015031biological_processprotein transport
s0016973biological_processpoly(A)+ mRNA export from nucleus
s0017056molecular_functionstructural constituent of nuclear pore
s0031965cellular_componentnuclear membrane
s0034399cellular_componentnuclear periphery
s0051028biological_processmRNA transport
s0051292biological_processnuclear pore complex assembly
Functional Information from PROSITE/UniProt
site_idPS00616
Number of Residues15
DetailsHIS_ACID_PHOSPHAT_1 Histidine acid phosphatases phosphohistidine signature. LlyAfhIyRHNyRkA
ChainResidueDetails
eLEU1078-ALA1092

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. IASVgdDhTCRIWDL
ChainResidueDetails
fILE140-LEU154
CVAL230-VAL244

site_idPS01358
Number of Residues20
DetailsZF_RANBP2_1 Zinc finger RanBP2-type signature. WqCdc..ClatNaptstsCvcC
ChainResidueDetails
KTRP1349-CYS1368
KTRP1413-CYS1432
KTRP1474-CYS1493
KTRP1534-CYS1553
KTRP1594-CYS1613
KTRP1661-CYS1680

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI2
Number of Residues78
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues82
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues100
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues78
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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