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7F9Y

ghrelin-bound ghrelin receptor in complex with Gq

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0005179molecular_functionhormone activity
C0005576cellular_componentextracellular region
C0016608molecular_functiongrowth hormone-releasing hormone activity
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0001616molecular_functiongrowth hormone secretagogue receptor activity
R0004930molecular_functionG protein-coupled receptor activity
R0005506molecular_functioniron ion binding
R0005886cellular_componentplasma membrane
R0007186biological_processG protein-coupled receptor signaling pathway
R0007283biological_processspermatogenesis
R0007565biological_processfemale pregnancy
R0007611biological_processlearning or memory
R0008154biological_processactin polymerization or depolymerization
R0008343biological_processadult feeding behavior
R0009055molecular_functionelectron transfer activity
R0009725biological_processresponse to hormone
R0009755biological_processhormone-mediated signaling pathway
R0009986cellular_componentcell surface
R0010700biological_processnegative regulation of norepinephrine secretion
R0016020cellular_componentmembrane
R0016520molecular_functiongrowth hormone-releasing hormone receptor activity
R0017046molecular_functionpeptide hormone binding
R0020037molecular_functionheme binding
R0022900biological_processelectron transport chain
R0030252biological_processgrowth hormone secretion
R0032094biological_processresponse to food
R0032099biological_processnegative regulation of appetite
R0032100biological_processpositive regulation of appetite
R0032354biological_processresponse to follicle-stimulating hormone
R0032355biological_processresponse to estradiol
R0032691biological_processnegative regulation of interleukin-1 beta production
R0032715biological_processnegative regulation of interleukin-6 production
R0032720biological_processnegative regulation of tumor necrosis factor production
R0032869biological_processcellular response to insulin stimulus
R0036321biological_processghrelin secretion
R0040018biological_processpositive regulation of multicellular organism growth
R0042562molecular_functionhormone binding
R0042597cellular_componentperiplasmic space
R0043005cellular_componentneuron projection
R0043134biological_processregulation of hindgut contraction
R0043568biological_processpositive regulation of insulin-like growth factor receptor signaling pathway
R0045121cellular_componentmembrane raft
R0045923biological_processpositive regulation of fatty acid metabolic process
R0045927biological_processpositive regulation of growth
R0046676biological_processnegative regulation of insulin secretion
R0046697biological_processdecidualization
R0046872molecular_functionmetal ion binding
R0048009biological_processinsulin-like growth factor receptor signaling pathway
R0050728biological_processnegative regulation of inflammatory response
R0051963biological_processregulation of synapse assembly
R0051969biological_processregulation of transmission of nerve impulse
R0060123biological_processregulation of growth hormone secretion
R0060259biological_processregulation of feeding behavior
R0060416biological_processresponse to growth hormone
R0071222biological_processcellular response to lipopolysaccharide
R0071548biological_processresponse to dexamethasone
R0090327biological_processnegative regulation of locomotion involved in locomotory behavior
R0097060cellular_componentsynaptic membrane
R0097067biological_processcellular response to thyroid hormone stimulus
R0098685cellular_componentSchaffer collateral - CA1 synapse
R0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
R0098794cellular_componentpostsynapse
R0098978cellular_componentglutamatergic synapse
R0099170biological_processpostsynaptic modulation of chemical synaptic transmission
R0099175biological_processregulation of postsynapse organization
R0120058biological_processpositive regulation of small intestinal transit
R1902065biological_processresponse to L-glutamate
R1903672biological_processpositive regulation of sprouting angiogenesis
R1904000biological_processpositive regulation of eating behavior
R1904349biological_processpositive regulation of small intestine smooth muscle contraction
R1905333biological_processregulation of gastric motility
R1905564biological_processpositive regulation of vascular endothelial cell proliferation
R1990314biological_processcellular response to insulin-like growth factor stimulus
R2000110biological_processnegative regulation of macrophage apoptotic process
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ATVlTITALSVERYFaI
ChainResidueDetails
RALA129-ILE145

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299
BVAL327-GLY341

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: axial binding residue
ChainResidueDetails
RTRP-99
RILE-4

site_idSWS_FT_FI2
Number of Residues102
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
RMET1-ALA40
RPRO97-LYS117
RVAL184-THR211
RPHE286-GLN302

site_idSWS_FT_FI3
Number of Residues25
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
RPRO41-LEU66

site_idSWS_FT_FI4
Number of Residues93
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
RVAL67-ARG72
RGLU140-LEU162
RGLY236-LYS263
RSER327-THR366

site_idSWS_FT_FI5
Number of Residues23
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
RGLU73-MET96

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RLEU118-VAL139

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RVAL163-GLY183

site_idSWS_FT_FI8
Number of Residues23
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RVAL212-ILE235

site_idSWS_FT_FI9
Number of Residues21
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RMET264-LEU285

site_idSWS_FT_FI10
Number of Residues23
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RTYR303-MET326

site_idSWS_FT_FI11
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN13
RASN27

222415

PDB entries from 2024-07-10

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