Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7F64

eIF2B-SFSV NSs

Functional Information from GO Data
ChainGOidnamespacecontents
A0002183biological_processcytoplasmic translational initiation
A0003743molecular_functiontranslation initiation factor activity
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005851cellular_componenteukaryotic translation initiation factor 2B complex
A0005886cellular_componentplasma membrane
A0006412biological_processtranslation
A0006413biological_processtranslational initiation
A0009408biological_processresponse to heat
A0009749biological_processresponse to glucose
A0014003biological_processoligodendrocyte development
A0016020cellular_componentmembrane
A0042802molecular_functionidentical protein binding
A0043434biological_processresponse to peptide hormone
A0045948biological_processpositive regulation of translational initiation
A0050852biological_processT cell receptor signaling pathway
B0002183biological_processcytoplasmic translational initiation
B0003743molecular_functiontranslation initiation factor activity
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005851cellular_componenteukaryotic translation initiation factor 2B complex
B0005886cellular_componentplasma membrane
B0006412biological_processtranslation
B0006413biological_processtranslational initiation
B0009408biological_processresponse to heat
B0009749biological_processresponse to glucose
B0014003biological_processoligodendrocyte development
B0016020cellular_componentmembrane
B0042802molecular_functionidentical protein binding
B0043434biological_processresponse to peptide hormone
B0045948biological_processpositive regulation of translational initiation
B0050852biological_processT cell receptor signaling pathway
C0001541biological_processovarian follicle development
C0002183biological_processcytoplasmic translational initiation
C0003743molecular_functiontranslation initiation factor activity
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005851cellular_componenteukaryotic translation initiation factor 2B complex
C0006412biological_processtranslation
C0006413biological_processtranslational initiation
C0006446biological_processregulation of translational initiation
C0007417biological_processcentral nervous system development
C0009408biological_processresponse to heat
C0009749biological_processresponse to glucose
C0014003biological_processoligodendrocyte development
C0042552biological_processmyelination
C0043434biological_processresponse to peptide hormone
C0045948biological_processpositive regulation of translational initiation
C0048513biological_processanimal organ development
C0050852biological_processT cell receptor signaling pathway
D0001541biological_processovarian follicle development
D0002183biological_processcytoplasmic translational initiation
D0003743molecular_functiontranslation initiation factor activity
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005851cellular_componenteukaryotic translation initiation factor 2B complex
D0006412biological_processtranslation
D0006413biological_processtranslational initiation
D0006446biological_processregulation of translational initiation
D0007417biological_processcentral nervous system development
D0009408biological_processresponse to heat
D0009749biological_processresponse to glucose
D0014003biological_processoligodendrocyte development
D0042552biological_processmyelination
D0043434biological_processresponse to peptide hormone
D0045948biological_processpositive regulation of translational initiation
D0048513biological_processanimal organ development
D0050852biological_processT cell receptor signaling pathway
E0002183biological_processcytoplasmic translational initiation
E0003743molecular_functiontranslation initiation factor activity
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005851cellular_componenteukaryotic translation initiation factor 2B complex
E0006412biological_processtranslation
E0006413biological_processtranslational initiation
E0007417biological_processcentral nervous system development
E0008135molecular_functiontranslation factor activity, RNA binding
E0009058biological_processbiosynthetic process
E0009408biological_processresponse to heat
E0009749biological_processresponse to glucose
E0014003biological_processoligodendrocyte development
E0043434biological_processresponse to peptide hormone
E0045948biological_processpositive regulation of translational initiation
E0050852biological_processT cell receptor signaling pathway
F0002183biological_processcytoplasmic translational initiation
F0003743molecular_functiontranslation initiation factor activity
F0005085molecular_functionguanyl-nucleotide exchange factor activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005851cellular_componenteukaryotic translation initiation factor 2B complex
F0006412biological_processtranslation
F0006413biological_processtranslational initiation
F0007417biological_processcentral nervous system development
F0008135molecular_functiontranslation factor activity, RNA binding
F0009058biological_processbiosynthetic process
F0009408biological_processresponse to heat
F0009749biological_processresponse to glucose
F0014003biological_processoligodendrocyte development
F0043434biological_processresponse to peptide hormone
F0045948biological_processpositive regulation of translational initiation
F0050852biological_processT cell receptor signaling pathway
G0001541biological_processovarian follicle development
G0002183biological_processcytoplasmic translational initiation
G0003743molecular_functiontranslation initiation factor activity
G0005085molecular_functionguanyl-nucleotide exchange factor activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005851cellular_componenteukaryotic translation initiation factor 2B complex
G0006412biological_processtranslation
G0006413biological_processtranslational initiation
G0006417biological_processregulation of translation
G0007417biological_processcentral nervous system development
G0009408biological_processresponse to heat
G0009749biological_processresponse to glucose
G0014003biological_processoligodendrocyte development
G0031369molecular_functiontranslation initiation factor binding
G0042552biological_processmyelination
G0043434biological_processresponse to peptide hormone
G0045948biological_processpositive regulation of translational initiation
G0048513biological_processanimal organ development
G0050852biological_processT cell receptor signaling pathway
H0001541biological_processovarian follicle development
H0002183biological_processcytoplasmic translational initiation
H0003743molecular_functiontranslation initiation factor activity
H0005085molecular_functionguanyl-nucleotide exchange factor activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005851cellular_componenteukaryotic translation initiation factor 2B complex
H0006412biological_processtranslation
H0006413biological_processtranslational initiation
H0006417biological_processregulation of translation
H0007417biological_processcentral nervous system development
H0009408biological_processresponse to heat
H0009749biological_processresponse to glucose
H0014003biological_processoligodendrocyte development
H0031369molecular_functiontranslation initiation factor binding
H0042552biological_processmyelination
H0043434biological_processresponse to peptide hormone
H0045948biological_processpositive regulation of translational initiation
H0048513biological_processanimal organ development
H0050852biological_processT cell receptor signaling pathway
I0001541biological_processovarian follicle development
I0002183biological_processcytoplasmic translational initiation
I0003743molecular_functiontranslation initiation factor activity
I0005085molecular_functionguanyl-nucleotide exchange factor activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005851cellular_componenteukaryotic translation initiation factor 2B complex
I0006412biological_processtranslation
I0006413biological_processtranslational initiation
I0009408biological_processresponse to heat
I0009749biological_processresponse to glucose
I0014002biological_processastrocyte development
I0014003biological_processoligodendrocyte development
I0021766biological_processhippocampus development
I0031369molecular_functiontranslation initiation factor binding
I0034976biological_processresponse to endoplasmic reticulum stress
I0042552biological_processmyelination
I0043065biological_processpositive regulation of apoptotic process
I0043434biological_processresponse to peptide hormone
I0045727biological_processpositive regulation of translation
I0045948biological_processpositive regulation of translational initiation
I0048708biological_processastrocyte differentiation
I0050852biological_processT cell receptor signaling pathway
J0001541biological_processovarian follicle development
J0002183biological_processcytoplasmic translational initiation
J0003743molecular_functiontranslation initiation factor activity
J0005085molecular_functionguanyl-nucleotide exchange factor activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005851cellular_componenteukaryotic translation initiation factor 2B complex
J0006412biological_processtranslation
J0006413biological_processtranslational initiation
J0009408biological_processresponse to heat
J0009749biological_processresponse to glucose
J0014002biological_processastrocyte development
J0014003biological_processoligodendrocyte development
J0021766biological_processhippocampus development
J0031369molecular_functiontranslation initiation factor binding
J0034976biological_processresponse to endoplasmic reticulum stress
J0042552biological_processmyelination
J0043065biological_processpositive regulation of apoptotic process
J0043434biological_processresponse to peptide hormone
J0045727biological_processpositive regulation of translation
J0045948biological_processpositive regulation of translational initiation
J0048708biological_processastrocyte differentiation
J0050852biological_processT cell receptor signaling pathway
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Boldt K.","von Kriegsheim A.F.","Kolch W."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues18
DetailsRegion: {"description":"May bind the chemical integrated stress response (ISR) inhibitor ISRIB","evidences":[{"source":"PubMed","id":"25858979","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q64350","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q64350","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues10
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q64350","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

PDB statisticsPDBj update infoContact PDBjnumon