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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7F3F

CryoEM structure of human Kv4.2-KChIP1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0005216molecular_functionmonoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005250molecular_functionA-type (transient outward) potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006936biological_processmuscle contraction
A0007268biological_processchemical synaptic transmission
A0008016biological_processregulation of heart contraction
A0008076cellular_componentvoltage-gated potassium channel complex
A0016020cellular_componentmembrane
A0019228biological_processneuronal action potential
A0019233biological_processsensory perception of pain
A0030425cellular_componentdendrite
A0032809cellular_componentneuronal cell body membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0043204cellular_componentperikaryon
A0044853cellular_componentplasma membrane raft
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045475biological_processlocomotor rhythm
A0046872molecular_functionmetal ion binding
A0051260biological_processprotein homooligomerization
A0055085biological_processtransmembrane transport
A0060078biological_processregulation of postsynaptic membrane potential
A0070161cellular_componentanchoring junction
A0071456biological_processcellular response to hypoxia
A0071805biological_processpotassium ion transmembrane transport
A0086009biological_processmembrane repolarization
A0098978cellular_componentglutamatergic synapse
A0098982cellular_componentGABA-ergic synapse
A0099634cellular_componentpostsynaptic specialization membrane
A1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005250molecular_functionA-type (transient outward) potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006936biological_processmuscle contraction
B0007268biological_processchemical synaptic transmission
B0008016biological_processregulation of heart contraction
B0008076cellular_componentvoltage-gated potassium channel complex
B0016020cellular_componentmembrane
B0019228biological_processneuronal action potential
B0019233biological_processsensory perception of pain
B0030425cellular_componentdendrite
B0032809cellular_componentneuronal cell body membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0043204cellular_componentperikaryon
B0044853cellular_componentplasma membrane raft
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0045475biological_processlocomotor rhythm
B0046872molecular_functionmetal ion binding
B0051260biological_processprotein homooligomerization
B0055085biological_processtransmembrane transport
B0060078biological_processregulation of postsynaptic membrane potential
B0070161cellular_componentanchoring junction
B0071456biological_processcellular response to hypoxia
B0071805biological_processpotassium ion transmembrane transport
B0086009biological_processmembrane repolarization
B0098978cellular_componentglutamatergic synapse
B0098982cellular_componentGABA-ergic synapse
B0099634cellular_componentpostsynaptic specialization membrane
B1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D0001508biological_processaction potential
D0005216molecular_functionmonoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005250molecular_functionA-type (transient outward) potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006936biological_processmuscle contraction
D0007268biological_processchemical synaptic transmission
D0008016biological_processregulation of heart contraction
D0008076cellular_componentvoltage-gated potassium channel complex
D0016020cellular_componentmembrane
D0019228biological_processneuronal action potential
D0019233biological_processsensory perception of pain
D0030425cellular_componentdendrite
D0032809cellular_componentneuronal cell body membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0043204cellular_componentperikaryon
D0044853cellular_componentplasma membrane raft
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0045475biological_processlocomotor rhythm
D0046872molecular_functionmetal ion binding
D0051260biological_processprotein homooligomerization
D0055085biological_processtransmembrane transport
D0060078biological_processregulation of postsynaptic membrane potential
D0070161cellular_componentanchoring junction
D0071456biological_processcellular response to hypoxia
D0071805biological_processpotassium ion transmembrane transport
D0086009biological_processmembrane repolarization
D0098978cellular_componentglutamatergic synapse
D0098982cellular_componentGABA-ergic synapse
D0099634cellular_componentpostsynaptic specialization membrane
D1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E0005267molecular_functionpotassium channel activity
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0006813biological_processpotassium ion transport
E0006936biological_processmuscle contraction
E0007268biological_processchemical synaptic transmission
E0008016biological_processregulation of heart contraction
E0008076cellular_componentvoltage-gated potassium channel complex
E0009898cellular_componentcytoplasmic side of plasma membrane
E0009966biological_processregulation of signal transduction
E0015459molecular_functionpotassium channel regulator activity
E0030425cellular_componentdendrite
E0034220biological_processmonoatomic ion transmembrane transport
E0034702cellular_componentmonoatomic ion channel complex
E0044325molecular_functiontransmembrane transporter binding
E0045202cellular_componentsynapse
E0046872molecular_functionmetal ion binding
E0071805biological_processpotassium ion transmembrane transport
E0086009biological_processmembrane repolarization
E0097623biological_processpotassium ion export across plasma membrane
E1901379biological_processregulation of potassium ion transmembrane transport
G0001508biological_processaction potential
G0005216molecular_functionmonoatomic ion channel activity
G0005249molecular_functionvoltage-gated potassium channel activity
G0005250molecular_functionA-type (transient outward) potassium channel activity
G0005267molecular_functionpotassium channel activity
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0006811biological_processmonoatomic ion transport
G0006813biological_processpotassium ion transport
G0006936biological_processmuscle contraction
G0007268biological_processchemical synaptic transmission
G0008016biological_processregulation of heart contraction
G0008076cellular_componentvoltage-gated potassium channel complex
G0016020cellular_componentmembrane
G0019228biological_processneuronal action potential
G0019233biological_processsensory perception of pain
G0030425cellular_componentdendrite
G0032809cellular_componentneuronal cell body membrane
G0034220biological_processmonoatomic ion transmembrane transport
G0034702cellular_componentmonoatomic ion channel complex
G0043025cellular_componentneuronal cell body
G0043197cellular_componentdendritic spine
G0043204cellular_componentperikaryon
G0044853cellular_componentplasma membrane raft
G0045202cellular_componentsynapse
G0045211cellular_componentpostsynaptic membrane
G0045475biological_processlocomotor rhythm
G0046872molecular_functionmetal ion binding
G0051260biological_processprotein homooligomerization
G0055085biological_processtransmembrane transport
G0060078biological_processregulation of postsynaptic membrane potential
G0070161cellular_componentanchoring junction
G0071456biological_processcellular response to hypoxia
G0071805biological_processpotassium ion transmembrane transport
G0086009biological_processmembrane repolarization
G0098978cellular_componentglutamatergic synapse
G0098982cellular_componentGABA-ergic synapse
G0099634cellular_componentpostsynaptic specialization membrane
G1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
H0005267molecular_functionpotassium channel activity
H0005509molecular_functioncalcium ion binding
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005886cellular_componentplasma membrane
H0006811biological_processmonoatomic ion transport
H0006813biological_processpotassium ion transport
H0006936biological_processmuscle contraction
H0007268biological_processchemical synaptic transmission
H0008016biological_processregulation of heart contraction
H0008076cellular_componentvoltage-gated potassium channel complex
H0009898cellular_componentcytoplasmic side of plasma membrane
H0009966biological_processregulation of signal transduction
H0015459molecular_functionpotassium channel regulator activity
H0030425cellular_componentdendrite
H0034220biological_processmonoatomic ion transmembrane transport
H0034702cellular_componentmonoatomic ion channel complex
H0044325molecular_functiontransmembrane transporter binding
H0045202cellular_componentsynapse
H0046872molecular_functionmetal ion binding
H0071805biological_processpotassium ion transmembrane transport
H0086009biological_processmembrane repolarization
H0097623biological_processpotassium ion export across plasma membrane
H1901379biological_processregulation of potassium ion transmembrane transport
J0005267molecular_functionpotassium channel activity
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005886cellular_componentplasma membrane
J0006811biological_processmonoatomic ion transport
J0006813biological_processpotassium ion transport
J0006936biological_processmuscle contraction
J0007268biological_processchemical synaptic transmission
J0008016biological_processregulation of heart contraction
J0008076cellular_componentvoltage-gated potassium channel complex
J0009898cellular_componentcytoplasmic side of plasma membrane
J0009966biological_processregulation of signal transduction
J0015459molecular_functionpotassium channel regulator activity
J0030425cellular_componentdendrite
J0034220biological_processmonoatomic ion transmembrane transport
J0034702cellular_componentmonoatomic ion channel complex
J0044325molecular_functiontransmembrane transporter binding
J0045202cellular_componentsynapse
J0046872molecular_functionmetal ion binding
J0071805biological_processpotassium ion transmembrane transport
J0086009biological_processmembrane repolarization
J0097623biological_processpotassium ion export across plasma membrane
J1901379biological_processregulation of potassium ion transmembrane transport
L0005267molecular_functionpotassium channel activity
L0005509molecular_functioncalcium ion binding
L0005515molecular_functionprotein binding
L0005737cellular_componentcytoplasm
L0005886cellular_componentplasma membrane
L0006811biological_processmonoatomic ion transport
L0006813biological_processpotassium ion transport
L0006936biological_processmuscle contraction
L0007268biological_processchemical synaptic transmission
L0008016biological_processregulation of heart contraction
L0008076cellular_componentvoltage-gated potassium channel complex
L0009898cellular_componentcytoplasmic side of plasma membrane
L0009966biological_processregulation of signal transduction
L0015459molecular_functionpotassium channel regulator activity
L0030425cellular_componentdendrite
L0034220biological_processmonoatomic ion transmembrane transport
L0034702cellular_componentmonoatomic ion channel complex
L0044325molecular_functiontransmembrane transporter binding
L0045202cellular_componentsynapse
L0046872molecular_functionmetal ion binding
L0071805biological_processpotassium ion transmembrane transport
L0086009biological_processmembrane repolarization
L0097623biological_processpotassium ion export across plasma membrane
L1901379biological_processregulation of potassium ion transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DINKDGYINkeEM
ChainResidueDetails
EASP135-MET147
EASP183-PHE195
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues76
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues72
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues92
DetailsTransmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues44
DetailsIntramembrane: {"description":"Helical; Name=Pore helix","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues28
DetailsIntramembrane: {"evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues72
DetailsRegion: {"description":"Interaction with KCNIP1, KCNIP2, and other family members","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues76
DetailsRegion: {"description":"Interaction with KCNIP1","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues52
DetailsRegion: {"description":"S4-S5 linker","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues60
DetailsRegion: {"description":"Required for dendritic targeting","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues20
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues12
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"34552243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F0J","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35597238","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35597238","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UKC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35597238","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UKG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q63881","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues140
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues140
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues52
DetailsRegion: {"description":"Interaction with KCND2","evidences":[{"source":"UniProtKB","id":"Q8R426","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues32
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17057713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17187064","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

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