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7F3F

CryoEM structure of human Kv4.2-KChIP1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0005216molecular_functionmonoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005250molecular_functionA-type (transient outward) potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006936biological_processmuscle contraction
A0007268biological_processchemical synaptic transmission
A0008016biological_processregulation of heart contraction
A0008076cellular_componentvoltage-gated potassium channel complex
A0016020cellular_componentmembrane
A0019228biological_processneuronal action potential
A0019233biological_processsensory perception of pain
A0030425cellular_componentdendrite
A0032809cellular_componentneuronal cell body membrane
A0034702cellular_componentmonoatomic ion channel complex
A0042995cellular_componentcell projection
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0043204cellular_componentperikaryon
A0044853cellular_componentplasma membrane raft
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045475biological_processlocomotor rhythm
A0046872molecular_functionmetal ion binding
A0051260biological_processprotein homooligomerization
A0055085biological_processtransmembrane transport
A0060078biological_processregulation of postsynaptic membrane potential
A0070161cellular_componentanchoring junction
A0071193cellular_componentKv4.2-KChIP2 channel complex
A0071456biological_processcellular response to hypoxia
A0071805biological_processpotassium ion transmembrane transport
A0086009biological_processmembrane repolarization
A0098978cellular_componentglutamatergic synapse
A0098982cellular_componentGABA-ergic synapse
A0099634cellular_componentpostsynaptic specialization membrane
A1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B0001508biological_processaction potential
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005250molecular_functionA-type (transient outward) potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006936biological_processmuscle contraction
B0007268biological_processchemical synaptic transmission
B0008016biological_processregulation of heart contraction
B0008076cellular_componentvoltage-gated potassium channel complex
B0016020cellular_componentmembrane
B0019228biological_processneuronal action potential
B0019233biological_processsensory perception of pain
B0030425cellular_componentdendrite
B0032809cellular_componentneuronal cell body membrane
B0034702cellular_componentmonoatomic ion channel complex
B0042995cellular_componentcell projection
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0043204cellular_componentperikaryon
B0044853cellular_componentplasma membrane raft
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0045475biological_processlocomotor rhythm
B0046872molecular_functionmetal ion binding
B0051260biological_processprotein homooligomerization
B0055085biological_processtransmembrane transport
B0060078biological_processregulation of postsynaptic membrane potential
B0070161cellular_componentanchoring junction
B0071193cellular_componentKv4.2-KChIP2 channel complex
B0071456biological_processcellular response to hypoxia
B0071805biological_processpotassium ion transmembrane transport
B0086009biological_processmembrane repolarization
B0098978cellular_componentglutamatergic synapse
B0098982cellular_componentGABA-ergic synapse
B0099634cellular_componentpostsynaptic specialization membrane
B1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D0001508biological_processaction potential
D0005216molecular_functionmonoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005250molecular_functionA-type (transient outward) potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006936biological_processmuscle contraction
D0007268biological_processchemical synaptic transmission
D0008016biological_processregulation of heart contraction
D0008076cellular_componentvoltage-gated potassium channel complex
D0016020cellular_componentmembrane
D0019228biological_processneuronal action potential
D0019233biological_processsensory perception of pain
D0030425cellular_componentdendrite
D0032809cellular_componentneuronal cell body membrane
D0034702cellular_componentmonoatomic ion channel complex
D0042995cellular_componentcell projection
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0043204cellular_componentperikaryon
D0044853cellular_componentplasma membrane raft
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0045475biological_processlocomotor rhythm
D0046872molecular_functionmetal ion binding
D0051260biological_processprotein homooligomerization
D0055085biological_processtransmembrane transport
D0060078biological_processregulation of postsynaptic membrane potential
D0070161cellular_componentanchoring junction
D0071193cellular_componentKv4.2-KChIP2 channel complex
D0071456biological_processcellular response to hypoxia
D0071805biological_processpotassium ion transmembrane transport
D0086009biological_processmembrane repolarization
D0098978cellular_componentglutamatergic synapse
D0098982cellular_componentGABA-ergic synapse
D0099634cellular_componentpostsynaptic specialization membrane
D1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E0005267molecular_functionpotassium channel activity
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005886cellular_componentplasma membrane
E0008076cellular_componentvoltage-gated potassium channel complex
E0009898cellular_componentcytoplasmic side of plasma membrane
E0015459molecular_functionpotassium channel regulator activity
E0030425cellular_componentdendrite
E0034702cellular_componentmonoatomic ion channel complex
E0042995cellular_componentcell projection
E0044325molecular_functiontransmembrane transporter binding
E0046872molecular_functionmetal ion binding
E0071805biological_processpotassium ion transmembrane transport
E1901379biological_processregulation of potassium ion transmembrane transport
G0001508biological_processaction potential
G0005216molecular_functionmonoatomic ion channel activity
G0005249molecular_functionvoltage-gated potassium channel activity
G0005250molecular_functionA-type (transient outward) potassium channel activity
G0005267molecular_functionpotassium channel activity
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0006811biological_processmonoatomic ion transport
G0006813biological_processpotassium ion transport
G0006936biological_processmuscle contraction
G0007268biological_processchemical synaptic transmission
G0008016biological_processregulation of heart contraction
G0008076cellular_componentvoltage-gated potassium channel complex
G0016020cellular_componentmembrane
G0019228biological_processneuronal action potential
G0019233biological_processsensory perception of pain
G0030425cellular_componentdendrite
G0032809cellular_componentneuronal cell body membrane
G0034702cellular_componentmonoatomic ion channel complex
G0042995cellular_componentcell projection
G0043025cellular_componentneuronal cell body
G0043197cellular_componentdendritic spine
G0043204cellular_componentperikaryon
G0044853cellular_componentplasma membrane raft
G0045202cellular_componentsynapse
G0045211cellular_componentpostsynaptic membrane
G0045475biological_processlocomotor rhythm
G0046872molecular_functionmetal ion binding
G0051260biological_processprotein homooligomerization
G0055085biological_processtransmembrane transport
G0060078biological_processregulation of postsynaptic membrane potential
G0070161cellular_componentanchoring junction
G0071193cellular_componentKv4.2-KChIP2 channel complex
G0071456biological_processcellular response to hypoxia
G0071805biological_processpotassium ion transmembrane transport
G0086009biological_processmembrane repolarization
G0098978cellular_componentglutamatergic synapse
G0098982cellular_componentGABA-ergic synapse
G0099634cellular_componentpostsynaptic specialization membrane
G1905030molecular_functionvoltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
H0005267molecular_functionpotassium channel activity
H0005509molecular_functioncalcium ion binding
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005886cellular_componentplasma membrane
H0008076cellular_componentvoltage-gated potassium channel complex
H0009898cellular_componentcytoplasmic side of plasma membrane
H0015459molecular_functionpotassium channel regulator activity
H0030425cellular_componentdendrite
H0034702cellular_componentmonoatomic ion channel complex
H0042995cellular_componentcell projection
H0044325molecular_functiontransmembrane transporter binding
H0046872molecular_functionmetal ion binding
H0071805biological_processpotassium ion transmembrane transport
H1901379biological_processregulation of potassium ion transmembrane transport
J0005267molecular_functionpotassium channel activity
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005886cellular_componentplasma membrane
J0008076cellular_componentvoltage-gated potassium channel complex
J0009898cellular_componentcytoplasmic side of plasma membrane
J0015459molecular_functionpotassium channel regulator activity
J0030425cellular_componentdendrite
J0034702cellular_componentmonoatomic ion channel complex
J0042995cellular_componentcell projection
J0044325molecular_functiontransmembrane transporter binding
J0046872molecular_functionmetal ion binding
J0071805biological_processpotassium ion transmembrane transport
J1901379biological_processregulation of potassium ion transmembrane transport
L0005267molecular_functionpotassium channel activity
L0005509molecular_functioncalcium ion binding
L0005515molecular_functionprotein binding
L0005737cellular_componentcytoplasm
L0005886cellular_componentplasma membrane
L0008076cellular_componentvoltage-gated potassium channel complex
L0009898cellular_componentcytoplasmic side of plasma membrane
L0015459molecular_functionpotassium channel regulator activity
L0030425cellular_componentdendrite
L0034702cellular_componentmonoatomic ion channel complex
L0042995cellular_componentcell projection
L0044325molecular_functiontransmembrane transporter binding
L0046872molecular_functionmetal ion binding
L0071805biological_processpotassium ion transmembrane transport
L1901379biological_processregulation of potassium ion transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DINKDGYINkeEM
ChainResidueDetails
EASP135-MET147
EASP183-PHE195

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues36
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:17057713, ECO:0000269|PubMed:17187064
ChainResidueDetails
EGLU146
EMET148
EILE150
EMET157
ELYS152
JILE150
JLYS152
JMET157
JGLU194
JLEU196
JSER198
JILE205
LGLU146
LMET148
LILE150
LLYS152
LMET157
LGLU194
LLEU196
LSER198
LILE205
EGLU194
ELEU196
ESER198
EILE205
HGLU146
HMET148
HILE150
HLYS152
HMET157
HGLU194
HLEU196
HSER198
HILE205
JGLU146
JMET148

site_idSWS_FT_FI2
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
AMET183-VAL204
BMET183-VAL204
DMET183-VAL204
GMET183-VAL204

site_idSWS_FT_FI3
Number of Residues192
DetailsTOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
AGLU205-ALA228
ATHR280-SER286
ATYR344-ILE357
APRO378-LYS384
BGLU205-ALA228
BTHR280-SER286
BTYR344-ILE357
BPRO378-LYS384
DGLU205-ALA228
DTHR280-SER286
DTYR344-ILE357
DPRO378-LYS384
GGLU205-ALA228
GTHR280-SER286
GTYR344-ILE357
GPRO378-LYS384

site_idSWS_FT_FI4
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
APHE229-ALA250
BPHE229-ALA250
DPHE229-ALA250
GPHE229-ALA250

site_idSWS_FT_FI5
Number of Residues68
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
AMET262-MET279
BMET262-MET279
DMET262-MET279
GMET262-MET279

site_idSWS_FT_FI6
Number of Residues76
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
AGLY287-HIS306
BGLY287-HIS306
DGLY287-HIS306
GGLY287-HIS306

site_idSWS_FT_FI7
Number of Residues84
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
ASER322-PHE343
BSER322-PHE343
DSER322-PHE343
GSER322-PHE343

site_idSWS_FT_FI8
Number of Residues44
DetailsINTRAMEM: Helical; Name=Pore helix => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
APRO358-THR369
BPRO358-THR369
DPRO358-THR369
GPRO358-THR369

site_idSWS_FT_FI9
Number of Residues28
DetailsINTRAMEM: INTRAMEM => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
ATHR370-VAL377
BTHR370-VAL377
DTHR370-VAL377
GTHR370-VAL377

site_idSWS_FT_FI10
Number of Residues112
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000250|UniProtKB:P63142
ChainResidueDetails
AILE385-TYR413
BILE385-TYR413
DILE385-TYR413
GILE385-TYR413

site_idSWS_FT_FI11
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q63881
ChainResidueDetails
BCYS132
BCYS133
DHIS105
DCYS132
DCYS133
GHIS105
GCYS132
GCYS133
ACYS133
BHIS105
AHIS105
ACYS132

site_idSWS_FT_FI12
Number of Residues12
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q63881
ChainResidueDetails
DTHR607
GTHR38
GTHR602
GTHR607
BTHR602
BTHR607
DTHR38
DTHR602
ATHR38
ATHR602
ATHR607
BTHR38

site_idSWS_FT_FI13
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q63881
ChainResidueDetails
GSER438
GSER548
ASER438
ASER548
BSER438
BSER548
DSER438
DSER548

site_idSWS_FT_FI14
Number of Residues16
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Z0V2
ChainResidueDetails
DSER552
DSER572
DSER575
DSER616
GSER552
GSER572
GSER575
GSER616
ASER552
ASER572
ASER575
ASER616
BSER552
BSER572
BSER575
BSER616

219869

PDB entries from 2024-05-15

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