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7F0M

Crystal Structure of human Pin1 complexed with a potent covalent inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000413biological_processprotein peptidyl-prolyl isomerization
A0001666biological_processresponse to hypoxia
A0001932biological_processregulation of protein phosphorylation
A0001934biological_processpositive regulation of protein phosphorylation
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0003774molecular_functioncytoskeletal motor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0007088biological_processregulation of mitotic nuclear division
A0008013molecular_functionbeta-catenin binding
A0010468biological_processregulation of gene expression
A0016607cellular_componentnuclear speck
A0016859molecular_functioncis-trans isomerase activity
A0030182biological_processneuron differentiation
A0030496cellular_componentmidbody
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0031434molecular_functionmitogen-activated protein kinase kinase binding
A0031647biological_processregulation of protein stability
A0032091biological_processnegative regulation of protein binding
A0032092biological_processpositive regulation of protein binding
A0032465biological_processregulation of cytokinesis
A0032794molecular_functionGTPase activating protein binding
A0035307biological_processpositive regulation of protein dephosphorylation
A0036064cellular_componentciliary basal body
A0042177biological_processnegative regulation of protein catabolic process
A0043547biological_processpositive regulation of GTPase activity
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046785biological_processmicrotubule polymerization
A0048156molecular_functiontau protein binding
A0050808biological_processsynapse organization
A0050815molecular_functionphosphoserine residue binding
A0050816molecular_functionphosphothreonine residue binding
A0050821biological_processprotein stabilization
A0051171biological_processobsolete regulation of nitrogen compound metabolic process
A0051219molecular_functionphosphoprotein binding
A0060255biological_processregulation of macromolecule metabolic process
A0060392biological_processnegative regulation of SMAD protein signal transduction
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0080090biological_processregulation of primary metabolic process
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0098978cellular_componentglutamatergic synapse
A0099524cellular_componentpostsynaptic cytosol
A1900180biological_processregulation of protein localization to nucleus
A1902430biological_processnegative regulation of amyloid-beta formation
A1990757molecular_functionubiquitin ligase activator activity
A2000146biological_processnegative regulation of cell motility
B0000413biological_processprotein peptidyl-prolyl isomerization
B0001666biological_processresponse to hypoxia
B0001932biological_processregulation of protein phosphorylation
B0001934biological_processpositive regulation of protein phosphorylation
B0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
B0003774molecular_functioncytoskeletal motor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0007088biological_processregulation of mitotic nuclear division
B0008013molecular_functionbeta-catenin binding
B0010468biological_processregulation of gene expression
B0016607cellular_componentnuclear speck
B0016859molecular_functioncis-trans isomerase activity
B0030182biological_processneuron differentiation
B0030496cellular_componentmidbody
B0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
B0031434molecular_functionmitogen-activated protein kinase kinase binding
B0031647biological_processregulation of protein stability
B0032091biological_processnegative regulation of protein binding
B0032092biological_processpositive regulation of protein binding
B0032465biological_processregulation of cytokinesis
B0032794molecular_functionGTPase activating protein binding
B0035307biological_processpositive regulation of protein dephosphorylation
B0036064cellular_componentciliary basal body
B0042177biological_processnegative regulation of protein catabolic process
B0043547biological_processpositive regulation of GTPase activity
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046785biological_processmicrotubule polymerization
B0048156molecular_functiontau protein binding
B0050808biological_processsynapse organization
B0050815molecular_functionphosphoserine residue binding
B0050816molecular_functionphosphothreonine residue binding
B0050821biological_processprotein stabilization
B0051171biological_processobsolete regulation of nitrogen compound metabolic process
B0051219molecular_functionphosphoprotein binding
B0060255biological_processregulation of macromolecule metabolic process
B0060392biological_processnegative regulation of SMAD protein signal transduction
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0080090biological_processregulation of primary metabolic process
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0098978cellular_componentglutamatergic synapse
B0099524cellular_componentpostsynaptic cytosol
B1900180biological_processregulation of protein localization to nucleus
B1902430biological_processnegative regulation of amyloid-beta formation
B1990757molecular_functionubiquitin ligase activator activity
B2000146biological_processnegative regulation of cell motility
C0000413biological_processprotein peptidyl-prolyl isomerization
C0001666biological_processresponse to hypoxia
C0001932biological_processregulation of protein phosphorylation
C0001934biological_processpositive regulation of protein phosphorylation
C0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
C0003774molecular_functioncytoskeletal motor activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0007088biological_processregulation of mitotic nuclear division
C0008013molecular_functionbeta-catenin binding
C0010468biological_processregulation of gene expression
C0016607cellular_componentnuclear speck
C0016859molecular_functioncis-trans isomerase activity
C0030182biological_processneuron differentiation
C0030496cellular_componentmidbody
C0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
C0031434molecular_functionmitogen-activated protein kinase kinase binding
C0031647biological_processregulation of protein stability
C0032091biological_processnegative regulation of protein binding
C0032092biological_processpositive regulation of protein binding
C0032465biological_processregulation of cytokinesis
C0032794molecular_functionGTPase activating protein binding
C0035307biological_processpositive regulation of protein dephosphorylation
C0036064cellular_componentciliary basal body
C0042177biological_processnegative regulation of protein catabolic process
C0043547biological_processpositive regulation of GTPase activity
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046785biological_processmicrotubule polymerization
C0048156molecular_functiontau protein binding
C0050808biological_processsynapse organization
C0050815molecular_functionphosphoserine residue binding
C0050816molecular_functionphosphothreonine residue binding
C0050821biological_processprotein stabilization
C0051171biological_processobsolete regulation of nitrogen compound metabolic process
C0051219molecular_functionphosphoprotein binding
C0060255biological_processregulation of macromolecule metabolic process
C0060392biological_processnegative regulation of SMAD protein signal transduction
C0070373biological_processnegative regulation of ERK1 and ERK2 cascade
C0080090biological_processregulation of primary metabolic process
C0090263biological_processpositive regulation of canonical Wnt signaling pathway
C0098978cellular_componentglutamatergic synapse
C0099524cellular_componentpostsynaptic cytosol
C1900180biological_processregulation of protein localization to nucleus
C1902430biological_processnegative regulation of amyloid-beta formation
C1990757molecular_functionubiquitin ligase activator activity
C2000146biological_processnegative regulation of cell motility
D0000413biological_processprotein peptidyl-prolyl isomerization
D0001666biological_processresponse to hypoxia
D0001932biological_processregulation of protein phosphorylation
D0001934biological_processpositive regulation of protein phosphorylation
D0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
D0003774molecular_functioncytoskeletal motor activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0007088biological_processregulation of mitotic nuclear division
D0008013molecular_functionbeta-catenin binding
D0010468biological_processregulation of gene expression
D0016607cellular_componentnuclear speck
D0016859molecular_functioncis-trans isomerase activity
D0030182biological_processneuron differentiation
D0030496cellular_componentmidbody
D0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
D0031434molecular_functionmitogen-activated protein kinase kinase binding
D0031647biological_processregulation of protein stability
D0032091biological_processnegative regulation of protein binding
D0032092biological_processpositive regulation of protein binding
D0032465biological_processregulation of cytokinesis
D0032794molecular_functionGTPase activating protein binding
D0035307biological_processpositive regulation of protein dephosphorylation
D0036064cellular_componentciliary basal body
D0042177biological_processnegative regulation of protein catabolic process
D0043547biological_processpositive regulation of GTPase activity
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046785biological_processmicrotubule polymerization
D0048156molecular_functiontau protein binding
D0050808biological_processsynapse organization
D0050815molecular_functionphosphoserine residue binding
D0050816molecular_functionphosphothreonine residue binding
D0050821biological_processprotein stabilization
D0051171biological_processobsolete regulation of nitrogen compound metabolic process
D0051219molecular_functionphosphoprotein binding
D0060255biological_processregulation of macromolecule metabolic process
D0060392biological_processnegative regulation of SMAD protein signal transduction
D0070373biological_processnegative regulation of ERK1 and ERK2 cascade
D0080090biological_processregulation of primary metabolic process
D0090263biological_processpositive regulation of canonical Wnt signaling pathway
D0098978cellular_componentglutamatergic synapse
D0099524cellular_componentpostsynaptic cytosol
D1900180biological_processregulation of protein localization to nucleus
D1902430biological_processnegative regulation of amyloid-beta formation
D1990757molecular_functionubiquitin ligase activator activity
D2000146biological_processnegative regulation of cell motility
Functional Information from PROSITE/UniProt
site_idPS01096
Number of Residues21
DetailsPPIC_PPIASE_1 PpiC-type peptidyl-prolyl cis-trans isomerase signature. FEsLAsqfSdcs.Saka..RGdLG
ChainResidueDetails
APHE103-GLY123

site_idPS01159
Number of Residues27
DetailsWW_DOMAIN_1 WW/rsp5/WWP domain signature. WekamsrssgrvYYfnhitnaSQWERP
ChainResidueDetails
ATRP11-PRO37

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER43
BSER43
CSER43
DSER43

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS46
BLYS46
CLYS46
DLYS46

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine; by DAPK1 => ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:29686383
ChainResidueDetails
ASER71
BSER71
CSER71
DSER71

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332
ChainResidueDetails
ASER108
BSER108
CSER108
DSER108

Catalytic Information from CSA
site_idMCSA1
Number of Residues5
DetailsM-CSA 511
ChainResidueDetails
AHIS59proton shuttle (general acid/base)
ACYS113covalently attached, electrostatic stabiliser
AGLN131electrostatic stabiliser
ASER154electrostatic stabiliser
AHIS157electrostatic stabiliser

site_idMCSA2
Number of Residues5
DetailsM-CSA 511
ChainResidueDetails
BHIS59proton shuttle (general acid/base)
BCYS113covalently attached, electrostatic stabiliser
BGLN131electrostatic stabiliser
BSER154electrostatic stabiliser
BHIS157electrostatic stabiliser

site_idMCSA3
Number of Residues5
DetailsM-CSA 511
ChainResidueDetails
CHIS59proton shuttle (general acid/base)
CCYS113covalently attached, electrostatic stabiliser
CGLN131electrostatic stabiliser
CSER154electrostatic stabiliser
CHIS157electrostatic stabiliser

site_idMCSA4
Number of Residues5
DetailsM-CSA 511
ChainResidueDetails
DHIS59proton shuttle (general acid/base)
DCYS113covalently attached, electrostatic stabiliser
DGLN131electrostatic stabiliser
DSER154electrostatic stabiliser
DHIS157electrostatic stabiliser

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PDB entries from 2024-05-15

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