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7ET7

Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with tricyclic small molecule inhibitor JBSNF-000028

Functional Information from GO Data
ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006769biological_processnicotinamide metabolic process
A0008112molecular_functionnicotinamide N-methyltransferase activity
A0008168molecular_functionmethyltransferase activity
A0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
A0009410biological_processresponse to xenobiotic stimulus
A0010243biological_processresponse to organonitrogen compound
A0030760molecular_functionpyridine N-methyltransferase activity
A0031100biological_processanimal organ regeneration
A0032259biological_processmethylation
A0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
A0045722biological_processpositive regulation of gluconeogenesis
A0090312biological_processpositive regulation of protein deacetylation
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006769biological_processnicotinamide metabolic process
B0008112molecular_functionnicotinamide N-methyltransferase activity
B0008168molecular_functionmethyltransferase activity
B0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
B0009410biological_processresponse to xenobiotic stimulus
B0010243biological_processresponse to organonitrogen compound
B0030760molecular_functionpyridine N-methyltransferase activity
B0031100biological_processanimal organ regeneration
B0032259biological_processmethylation
B0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
B0045722biological_processpositive regulation of gluconeogenesis
B0090312biological_processpositive regulation of protein deacetylation
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006769biological_processnicotinamide metabolic process
C0008112molecular_functionnicotinamide N-methyltransferase activity
C0008168molecular_functionmethyltransferase activity
C0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
C0009410biological_processresponse to xenobiotic stimulus
C0010243biological_processresponse to organonitrogen compound
C0030760molecular_functionpyridine N-methyltransferase activity
C0031100biological_processanimal organ regeneration
C0032259biological_processmethylation
C0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
C0045722biological_processpositive regulation of gluconeogenesis
C0090312biological_processpositive regulation of protein deacetylation
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006769biological_processnicotinamide metabolic process
D0008112molecular_functionnicotinamide N-methyltransferase activity
D0008168molecular_functionmethyltransferase activity
D0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
D0009410biological_processresponse to xenobiotic stimulus
D0010243biological_processresponse to organonitrogen compound
D0030760molecular_functionpyridine N-methyltransferase activity
D0031100biological_processanimal organ regeneration
D0032259biological_processmethylation
D0034356biological_processNAD biosynthesis via nicotinamide riboside salvage pathway
D0045722biological_processpositive regulation of gluconeogenesis
D0090312biological_processpositive regulation of protein deacetylation
Functional Information from PROSITE/UniProt
site_idPS01100
Number of Residues17
DetailsNNMT_PNMT_TEMT NNMT/PNMT/TEMT family of methyltransferases signature. LIDIGSGPTIYQLLSAC
ChainResidueDetails
ALEU59-CYS75

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues32
DetailsBINDING: BINDING => ECO:0000269|PubMed:21823666, ECO:0000269|Ref.12
ChainResidueDetails
ATYR20
ATYR25
CASP85
CASN90
CASP142
CTHR163
DTYR20
DTYR25
DGLY63
DTYR69
DASP85
DASN90
DASP142
DTHR163
AGLY63
ATYR69
AASP85
AASN90
AASP142
ATHR163
BTYR20
BTYR25
BGLY63
BTYR69
BASP85
BASN90
BASP142
BTHR163
CTYR20
CTYR25
CGLY63
CTYR69

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:21823666
ChainResidueDetails
AASP197
ASER213
BASP197
BSER213
CASP197
CSER213
DASP197
DSER213

site_idSWS_FT_FI3
Number of Residues12
DetailsMOD_RES: Citrulline; alternate => ECO:0000269|PubMed:30044909
ChainResidueDetails
CARG181
DARG18
DARG132
DARG181
AARG18
AARG132
AARG181
BARG18
BARG132
BARG181
CARG18
CARG132

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS39
BLYS39
CLYS39
DLYS39

219869

PDB entries from 2024-05-15

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