Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7ERE

Crystal structure of human Biliverdin IX-beta reductase B with Pyrantel Pamoate (PPA)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004074	molecular_function	biliverdin reductase [NAD(P)+] activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008752	molecular_function	FMN reductase (NAD(P)H) activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0030219	biological_process	megakaryocyte differentiation
A	0035605	molecular_function	peptidyl-cysteine S-nitrosylase activity
A	0042167	biological_process	heme catabolic process
A	0042602	molecular_function	riboflavin reductase (NADPH) activity
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046627	biological_process	negative regulation of insulin receptor signaling pathway
A	0052873	molecular_function	FMN reductase (NADPH) activity
A	0052874	molecular_function	FMN reductase (NADH) activity
A	0070062	cellular_component	extracellular exosome
B	0004074	molecular_function	biliverdin reductase [NAD(P)+] activity
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008752	molecular_function	FMN reductase (NAD(P)H) activity
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0030219	biological_process	megakaryocyte differentiation
B	0035605	molecular_function	peptidyl-cysteine S-nitrosylase activity
B	0042167	biological_process	heme catabolic process
B	0042602	molecular_function	riboflavin reductase (NADPH) activity
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046627	biological_process	negative regulation of insulin receptor signaling pathway
B	0052873	molecular_function	FMN reductase (NADPH) activity
B	0052874	molecular_function	FMN reductase (NADH) activity
B	0070062	cellular_component	extracellular exosome
C	0004074	molecular_function	biliverdin reductase [NAD(P)+] activity
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0008752	molecular_function	FMN reductase (NAD(P)H) activity
C	0016491	molecular_function	oxidoreductase activity
C	0016740	molecular_function	transferase activity
C	0030219	biological_process	megakaryocyte differentiation
C	0035605	molecular_function	peptidyl-cysteine S-nitrosylase activity
C	0042167	biological_process	heme catabolic process
C	0042602	molecular_function	riboflavin reductase (NADPH) activity
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0046627	biological_process	negative regulation of insulin receptor signaling pathway
C	0052873	molecular_function	FMN reductase (NADPH) activity
C	0052874	molecular_function	FMN reductase (NADH) activity
C	0070062	cellular_component	extracellular exosome
D	0004074	molecular_function	biliverdin reductase [NAD(P)+] activity
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0008752	molecular_function	FMN reductase (NAD(P)H) activity
D	0016491	molecular_function	oxidoreductase activity
D	0016740	molecular_function	transferase activity
D	0030219	biological_process	megakaryocyte differentiation
D	0035605	molecular_function	peptidyl-cysteine S-nitrosylase activity
D	0042167	biological_process	heme catabolic process
D	0042602	molecular_function	riboflavin reductase (NADPH) activity
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0046627	biological_process	negative regulation of insulin receptor signaling pathway
D	0052873	molecular_function	FMN reductase (NADPH) activity
D	0052874	molecular_function	FMN reductase (NADH) activity
D	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	38
Details	binding site for residue NAP A 401

Chain	Residue
A	GLY10
A	LEU74
A	LEU75
A	GLY76
A	ARG78
A	VAL86
A	MET87
A	CYS109
A	THR110
A	HIS132
A	PRO151
A	THR12
A	PRO152
A	HIS153
A	ILE154
A	JBR402
A	HOH515
A	HOH521
A	HOH523
A	HOH525
A	HOH537
A	HOH549
A	GLY13
A	HOH572
A	HOH573
A	HOH579
A	HOH589
A	HOH621
A	HOH631
D	SER82
D	HOH551
D	HOH610
A	GLN14
A	THR15
A	ARG35
A	SER38
A	ASP54
A	VAL55

site_id	AC2
Number of Residues	14
Details	binding site for residue JBR A 402

Chain	Residue
A	ALA112
A	PHE113
A	TRP116
A	ARG124
A	PRO152
A	HIS153
A	ARG170
A	ARG174
A	TYR200
A	NAP401
A	HOH531
C	HIS0
C	MET1
C	ALA2

site_id	AC3
Number of Residues	12
Details	binding site for residue JBR A 403

Chain	Residue
A	SER88
A	GLU89
A	ARG92
A	ARG134
A	LYS137
A	HOH509
A	HOH582
B	GLN14
B	PHE113
B	VAL128
B	HIS153
B	NAP401

site_id	AC4
Number of Residues	1
Details	binding site for residue SO4 A 404

Chain	Residue
A	ARG170

site_id	AC5
Number of Residues	30
Details	binding site for residue NAP B 401

Chain	Residue
A	JBR403
B	GLY10
B	THR12
B	GLY13
B	GLN14
B	THR15
B	ARG35
B	ARG39
B	ASP54
B	VAL55
B	LEU74
B	LEU75
B	GLY76
B	ARG78
B	CYS109
B	THR110
B	SER111
B	HIS132
B	PRO151
B	PRO152
B	ILE154
B	HOH524
B	HOH537
B	HOH540
B	HOH554
B	HOH562
B	HOH589
B	HOH596
B	HOH614
C	SER37

site_id	AC6
Number of Residues	10
Details	binding site for residue SO4 B 402

Chain	Residue
B	ASP156
B	GLN157
B	HOH502
B	HOH504
B	HOH578
B	HOH580
A	LYS137
A	ARG140
B	HIS153
B	GLY155

site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 B 403

Chain	Residue
A	LEU159
B	ALA26
B	TYR28
B	HOH561
B	HOH564
B	HOH613

site_id	AC8
Number of Residues	36
Details	binding site for residue NAP C 401

Chain	Residue
B	SER82
B	HOH547
C	GLY10
C	THR12
C	GLY13
C	GLN14
C	THR15
C	ARG35
C	SER38
C	ASP54
C	VAL55
C	LEU74
C	LEU75
C	GLY76
C	ARG78
C	VAL86
C	MET87
C	CYS109
C	THR110
C	HIS132
C	PRO151
C	PRO152
C	HIS153
C	ILE154
C	HOH516
C	HOH525
C	HOH531
C	HOH532
C	HOH550
C	HOH555
C	HOH579
C	HOH585
C	HOH592
C	HOH626
C	HOH631
C	HOH653

site_id	AC9
Number of Residues	15
Details	binding site for residue JBR C 402

Chain	Residue
A	HIS0
A	MET1
A	ALA2
C	ALA112
C	PHE113
C	TRP116
C	ARG124
C	PRO151
C	PRO152
C	HIS153
C	ARG170
C	ARG174
C	TYR200
C	HOH502
C	HOH557

site_id	AD1
Number of Residues	5
Details	binding site for residue SO4 C 403

Chain	Residue
C	SER173
C	ARG174
C	VAL175
C	HOH505
C	HOH518

site_id	AD2
Number of Residues	32
Details	binding site for residue NAP D 401

Chain	Residue
A	SER37
D	GLY10
D	THR12
D	GLY13
D	GLN14
D	THR15
D	ARG35
D	ARG39
D	ASP54
D	VAL55
D	LEU74
D	LEU75
D	GLY76
D	ARG78
D	CYS109
D	THR110
D	SER111
D	HIS132
D	PRO151
D	PRO152
D	HIS153
D	ILE154
D	JBR402
D	HOH513
D	HOH541
D	HOH544
D	HOH549
D	HOH550
D	HOH578
D	HOH588
D	HOH621
D	HOH627

site_id	AD3
Number of Residues	13
Details	binding site for residue JBR D 402

Chain	Residue
C	SER88
C	ARG134
C	LYS137
C	VAL138
C	HOH503
C	HOH551
C	HOH617
D	ARG78
D	PHE113
D	HIS153
D	NAP401
D	HOH527
D	HOH603

site_id	AD4
Number of Residues	8
Details	binding site for residue SO4 D 403

Chain	Residue
C	LYS137
C	ARG140
D	HIS153
D	GLY155
D	ASP156
D	GLN157
D	HOH503
D	HOH569

site_id	AD5
Number of Residues	8
Details	binding site for residue SO4 D 404

Chain	Residue
D	VAL3
D	ALA26
D	TYR28
D	HOH564
D	HOH571
D	HOH617
D	HOH624
D	HOH633

site_id	AD6
Number of Residues	4
Details	binding site for residue SO4 D 405

Chain	Residue
C	HIS183
D	LYS4
D	HOH531
D	HOH629

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: S-nitroso-cysteine intermediate; for S-nitroso-CoA-dependent nitrosyltransferase activity => ECO:0000269\|PubMed:38056462

Chain	Residue	Details
A	CYS109
A	CYS188
B	CYS109
B	CYS188
C	CYS109
C	CYS188
D	CYS109
D	CYS188

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:11224564, ECO:0000269\|PubMed:29487133, ECO:0000269\|PubMed:34957824, ECO:0007744\|PDB:1HDO, ECO:0007744\|PDB:5OOG, ECO:0007744\|PDB:5OOH, ECO:0007744\|PDB:7ER7

Chain	Residue	Details
A	GLY10
B	GLY10
C	GLY10
D	GLY10

site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269\|PubMed:11224564, ECO:0000269\|PubMed:29487133, ECO:0000269\|PubMed:32246827, ECO:0000269\|PubMed:34957824, ECO:0007744\|PDB:1HDO, ECO:0007744\|PDB:1HE2, ECO:0007744\|PDB:1HE3, ECO:0007744\|PDB:1HE4, ECO:0007744\|PDB:1HE5, ECO:0007744\|PDB:5OOG, ECO:0007744\|PDB:5OOH, ECO:0007744\|PDB:6OPL, ECO:0007744\|PDB:7ER6, ECO:0007744\|PDB:7ER7, ECO:0007744\|PDB:7ER8, ECO:0007744\|PDB:7ER9, ECO:0007744\|PDB:7ERA, ECO:0007744\|PDB:7ERB, ECO:0007744\|PDB:7ERC, ECO:0007744\|PDB:7ERD, ECO:0007744\|PDB:7ERE

Chain	Residue	Details
A	THR12
B	THR15
B	ARG35
B	ASP54
B	VAL55
B	GLY76
B	ARG78
B	MET87
C	THR12
C	THR15
C	ARG35
A	THR15
C	ASP54
C	VAL55
C	GLY76
C	ARG78
C	MET87
D	THR12
D	THR15
D	ARG35
D	ASP54
D	VAL55
A	ARG35
D	GLY76
D	ARG78
D	MET87
A	ASP54
A	VAL55
A	GLY76
A	ARG78
A	MET87
B	THR12

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:11224564, ECO:0000269\|PubMed:32246827, ECO:0000269\|PubMed:34957824, ECO:0007744\|PDB:1HDO, ECO:0007744\|PDB:1HE2, ECO:0007744\|PDB:1HE3, ECO:0007744\|PDB:1HE4, ECO:0007744\|PDB:1HE5, ECO:0007744\|PDB:5OOG, ECO:0007744\|PDB:5OOH, ECO:0007744\|PDB:6OPL, ECO:0007744\|PDB:7ER6, ECO:0007744\|PDB:7ER7, ECO:0007744\|PDB:7ER8, ECO:0007744\|PDB:7ER9, ECO:0007744\|PDB:7ERA, ECO:0007744\|PDB:7ERB, ECO:0007744\|PDB:7ERC, ECO:0007744\|PDB:7ERD, ECO:0007744\|PDB:7ERE

Chain	Residue	Details
A	GLY13
B	GLY13
C	GLY13
D	GLY13

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:11224564, ECO:0000269\|PubMed:29487133, ECO:0000269\|PubMed:34957824, ECO:0007744\|PDB:1HDO, ECO:0007744\|PDB:1HE2, ECO:0007744\|PDB:1HE3, ECO:0007744\|PDB:1HE4, ECO:0007744\|PDB:1HE5, ECO:0007744\|PDB:5OOG, ECO:0007744\|PDB:5OOH, ECO:0007744\|PDB:7ER6, ECO:0007744\|PDB:7ER7, ECO:0007744\|PDB:7ER8, ECO:0007744\|PDB:7ER9, ECO:0007744\|PDB:7ERA, ECO:0007744\|PDB:7ERB, ECO:0007744\|PDB:7ERC, ECO:0007744\|PDB:7ERD, ECO:0007744\|PDB:7ERE

Chain	Residue	Details
A	GLN14
A	ILE154
B	GLN14
B	ILE154
C	GLN14
C	ILE154
D	GLN14
D	ILE154

site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:34957824, ECO:0007744\|PDB:7ER6, ECO:0007744\|PDB:7ER9, ECO:0007744\|PDB:7ERA, ECO:0007744\|PDB:7ERB, ECO:0007744\|PDB:7ERD, ECO:0007744\|PDB:7ERE

Chain	Residue	Details
A	SER38
B	SER38
C	SER38
D	SER38

site_id	SWS_FT_FI7
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:29487133, ECO:0000269\|PubMed:32246827, ECO:0000269\|PubMed:34957824, ECO:0007744\|PDB:5OOH, ECO:0007744\|PDB:6OPL, ECO:0007744\|PDB:7ER6, ECO:0007744\|PDB:7ER7, ECO:0007744\|PDB:7ER8, ECO:0007744\|PDB:7ER9, ECO:0007744\|PDB:7ERA, ECO:0007744\|PDB:7ERB, ECO:0007744\|PDB:7ERC, ECO:0007744\|PDB:7ERE

Chain	Residue	Details
A	ARG39
B	ARG39
C	ARG39
D	ARG39

site_id	SWS_FT_FI8
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:11224564, ECO:0000269\|PubMed:32246827, ECO:0000269\|PubMed:34957824, ECO:0007744\|PDB:1HDO, ECO:0007744\|PDB:1HE2, ECO:0007744\|PDB:1HE3, ECO:0007744\|PDB:1HE4, ECO:0007744\|PDB:1HE5, ECO:0007744\|PDB:6OPL, ECO:0007744\|PDB:7ER6, ECO:0007744\|PDB:7ER7, ECO:0007744\|PDB:7ER8, ECO:0007744\|PDB:7ER9, ECO:0007744\|PDB:7ERA, ECO:0007744\|PDB:7ERB, ECO:0007744\|PDB:7ERC, ECO:0007744\|PDB:7ERD, ECO:0007744\|PDB:7ERE

Chain	Residue	Details
A	LEU75
B	LEU75
C	LEU75
D	LEU75

site_id	SWS_FT_FI9
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:11224564, ECO:0000269\|PubMed:29487133, ECO:0000269\|PubMed:32246827, ECO:0000269\|PubMed:34957824, ECO:0007744\|PDB:1HDO, ECO:0007744\|PDB:1HE2, ECO:0007744\|PDB:1HE3, ECO:0007744\|PDB:1HE4, ECO:0007744\|PDB:1HE5, ECO:0007744\|PDB:5OOH, ECO:0007744\|PDB:6OPL, ECO:0007744\|PDB:7ER6, ECO:0007744\|PDB:7ER7, ECO:0007744\|PDB:7ER8, ECO:0007744\|PDB:7ER9, ECO:0007744\|PDB:7ERA, ECO:0007744\|PDB:7ERB, ECO:0007744\|PDB:7ERC, ECO:0007744\|PDB:7ERD, ECO:0007744\|PDB:7ERE

Chain	Residue	Details
A	CYS109
B	CYS109
C	CYS109
D	CYS109

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:11224564, ECO:0000269\|PubMed:29487133, ECO:0000269\|PubMed:32246827, ECO:0000269\|PubMed:34957824, ECO:0007744\|PDB:1HE3, ECO:0007744\|PDB:5OOG, ECO:0007744\|PDB:5OOH, ECO:0007744\|PDB:6OPL, ECO:0007744\|PDB:7ER8, ECO:0007744\|PDB:7ER9, ECO:0007744\|PDB:7ERB, ECO:0007744\|PDB:7ERC

Chain	Residue	Details
A	HIS132
B	HIS132
C	HIS132
D	HIS132

site_id	SWS_FT_FI11
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:32246827, ECO:0000269\|PubMed:34957824, ECO:0007744\|PDB:6OPL, ECO:0007744\|PDB:7ERB, ECO:0007744\|PDB:7ERD

Chain	Residue	Details
A	HIS153
B	HIS153
C	HIS153
D	HIS153

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER42
B	SER42
C	SER42
D	SER42

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER82
B	SER82
C	SER82
D	SER82

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)