Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7EQ1

GPR114-Gs-scFv16 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0019001	molecular_function	guanyl nucleotide binding
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
B	0001750	cellular_component	photoreceptor outer segment
B	0001917	cellular_component	photoreceptor inner segment
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005834	cellular_component	heterotrimeric G-protein complex
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
B	0008283	biological_process	cell population proliferation
B	0010659	biological_process	cardiac muscle cell apoptotic process
B	0030159	molecular_function	signaling receptor complex adaptor activity
B	0030425	cellular_component	dendrite
B	0030507	molecular_function	spectrin binding
B	0042622	cellular_component	photoreceptor outer segment membrane
B	0044297	cellular_component	cell body
B	0044877	molecular_function	protein-containing complex binding
B	0045202	cellular_component	synapse
B	0047391	molecular_function	alkylglycerophosphoethanolamine phosphodiesterase activity
B	0050909	biological_process	sensory perception of taste
B	0051020	molecular_function	GTPase binding
B	0060041	biological_process	retina development in camera-type eye
B	0071456	biological_process	cellular response to hypoxia
R	0004888	molecular_function	transmembrane signaling receptor activity
R	0004930	molecular_function	G protein-coupled receptor activity
R	0007166	biological_process	cell surface receptor signaling pathway
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0016020	cellular_component	membrane
Y	0003924	molecular_function	GTPase activity
Y	0005515	molecular_function	protein binding
Y	0005834	cellular_component	heterotrimeric G-protein complex
Y	0005886	cellular_component	plasma membrane
Y	0007165	biological_process	signal transduction
Y	0007186	biological_process	G protein-coupled receptor signaling pathway
Y	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
Y	0016020	cellular_component	membrane
Y	0031681	molecular_function	G-protein beta-subunit binding
Y	0071380	biological_process	cellular response to prostaglandin E stimulus
Y	0071870	biological_process	cellular response to catecholamine stimulus

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
B	LEU70-SER84
B	ILE157-ILE171
B	LEU285-ALA299

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"35418678","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EQ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"35418678","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EQ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"35418678","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EQ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	44
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"35418678","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EQ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"35418678","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EQ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"35418678","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EQ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"35418678","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EQ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"35418678","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EQ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"35418678","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EQ1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	8
Details	Region: {"description":"Stachel","evidences":[{"source":"PubMed","id":"35418678","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	48
Details	Repeat: {"description":"WD 1","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	45
Details	Repeat: {"description":"WD 2","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	40
Details	Repeat: {"description":"WD 3","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	41
Details	Repeat: {"description":"WD 4","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	43
Details	Repeat: {"description":"WD 5","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	41
Details	Repeat: {"description":"WD 6","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	30
Details	Repeat: {"description":"WD 7","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)