7EPW

Crystal structure of monooxygenase Tet(X4) with tigecycline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004497	molecular_function	monooxygenase activity
A	0005737	cellular_component	cytoplasm
A	0046677	biological_process	response to antibiotic
A	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	binding site for residue FDA A 401

Chain	Residue
A	GLY23
A	ARG117
A	ARG121
A	ARG137
A	LYS138
A	LEU139
A	ASN168
A	GLY169
A	GLY310
A	ASP311
A	GLY323
A	GLY25
A	VAL324
A	T1C402
A	HOH507
A	HOH519
A	HOH521
A	HOH529
A	HOH563
A	HOH570
A	PRO26
A	VAL27
A	TYR45
A	GLU46
A	ARG47
A	THR59
A	LEU60

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site_id	AC2
Number of Residues	13
Details	binding site for residue T1C A 402

Chain	Residue
A	GLN192
A	ARG213
A	MET215
A	PHE224
A	ALA225
A	HIS234
A	SER238
A	PHE319
A	ALA320
A	GLY321
A	MET375
A	FDA401
A	HOH515

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