7EPV

Crystal structure of tigecycline degrading monooxygenase Tet(X4)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004497	molecular_function	monooxygenase activity
A	0005737	cellular_component	cytoplasm
A	0016491	molecular_function	oxidoreductase activity
A	0046677	biological_process	response to antibiotic
A	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	binding site for residue FDA A 401

Chain	Residue
A	GLY23
A	ARG117
A	ARG121
A	ARG137
A	LYS138
A	LEU139
A	ASN168
A	GLN192
A	LEU287
A	GLY310
A	ASP311
A	GLY25
A	PRO318
A	GLY323
A	VAL324
A	HOH546
A	HOH563
A	HOH567
A	HOH610
A	HOH615
A	HOH630
A	HOH645
A	PRO26
A	HOH648
A	HOH661
A	HOH673
A	HOH686
A	VAL27
A	TYR45
A	GLU46
A	ARG47
A	ASP48
A	LEU60

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site_id	AC2
Number of Residues	9
Details	binding site for residue GOL A 402

Chain	Residue
A	LEU83
A	GLU114
A	ILE115
A	ASN116
A	ASP119
A	ASN228
A	ASN230
A	GOL403
A	HOH542

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site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 403

Chain	Residue
A	LEU83
A	ALA84
A	ASN230
A	GOL402
A	HOH511
A	HOH542

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site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 404

Chain	Residue
A	TYR81
A	ALA84
A	PRO86
A	ARG109
A	PRO113
A	HOH596

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