7EOU
Structure of the human GluN1/GluN2A NMDA receptor in the glycine/glutamate/GNE-6901/9-AA bound state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1408 |
| Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P35439 |
| Chain | Residue | Details |
| B | ARG19-GLN559 | |
| B | THR648-ASN812 | |
| D | ARG19-GLN559 | |
| D | THR648-ASN812 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 112 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:P35439 |
| Chain | Residue | Details |
| B | SER560-LEU580 | |
| B | ILE631-TYR647 | |
| B | MET813-ILE833 | |
| D | SER560-LEU580 | |
| D | ILE631-TYR647 | |
| D | MET813-ILE833 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 52 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P35439 |
| Chain | Residue | Details |
| B | ASP581-THR602 | |
| B | ARG625-ARG630 | |
| D | ASP581-THR602 | |
| D | ARG625-ARG630 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 42 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:A0A1L8F5J9 |
| Chain | Residue | Details |
| B | LEU603-PRO624 | |
| D | LEU603-PRO624 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0007744|PDB:5H8F, ECO:0007744|PDB:5H8H, ECO:0007744|PDB:5H8N, ECO:0007744|PDB:5H8Q, ECO:0007744|PDB:5I2K, ECO:0007744|PDB:5I2N, ECO:0007744|PDB:5KCJ, ECO:0007744|PDB:5KDT, ECO:0007744|PDB:5TP9, ECO:0007744|PDB:5TPA |
| Chain | Residue | Details |
| B | PRO516 | |
| C | ASP282 | |
| C | SER689 | |
| C | TYR730 | |
| B | ARG523 | |
| B | SER688 | |
| B | ASP732 | |
| D | PRO516 | |
| D | ARG523 | |
| D | SER688 | |
| D | ASP732 | |
| C | GLU266 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN61 | |
| B | ASN491 | |
| B | ASN674 | |
| B | ASN771 | |
| D | ASN61 | |
| D | ASN203 | |
| D | ASN239 | |
| D | ASN276 | |
| D | ASN300 | |
| D | ASN350 | |
| D | ASN368 | |
| B | ASN203 | |
| D | ASN440 | |
| D | ASN471 | |
| D | ASN491 | |
| D | ASN674 | |
| D | ASN771 | |
| B | ASN239 | |
| B | ASN276 | |
| B | ASN300 | |
| B | ASN350 | |
| B | ASN368 | |
| B | ASN440 | |
| B | ASN471 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Functional determinant of NMDA receptors => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN614 | |
| C | ASN614 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 14 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN75 | |
| C | ASN380 | |
| C | ASN443 | |
| C | ASN444 | |
| C | ASN541 | |
| C | ASN687 | |
| A | ASN340 | |
| A | ASN380 | |
| A | ASN443 | |
| A | ASN444 | |
| A | ASN541 | |
| A | ASN687 | |
| C | ASN75 | |
| C | ASN340 |
